■本研究旨在确定病因,社会人口统计学,和性传播感染的临床特征,以及深圳生殖道的抗药性水平,中国南方具有代表性的一线城市。
进行了一项多中心横断面研究,来自22家医院的7886名性活跃参与者参加了性传播感染相关科室。九种与性传播感染相关的生物,包括淋病奈瑟菌,C.沙眼,T.阴道病,生殖M,HSV-1,HSV-2,人马,U.parvum,筛选解脲杆菌。
■单身或离婚与淋病奈瑟菌的检出率增加有关,C.沙眼,生殖M,HSV-1、HSV-2和人分枝杆菌。较低的教育水平与沙眼衣原体的检测增加有关,HSV-2和人源分枝杆菌。无保险是阴道毛虫的独立风险因素,人马和拟南芥阳性。在154个生殖支原体阳性样品中,对与大环内酯和氟喹诺酮相关的三个耐药性测定区进行了测序,其中90.3%存在与大环内酯类或氟喹诺酮类耐药相关的突变,67.5%为耐多药生殖分枝杆菌。23SrRNA中的A2072G和parC中的Ser83Ile是最常见的突变。人型支原体与女性细菌性阴道病和男性附睾炎的表现有关。
■单身或离婚的个人,受教育程度较低的人群和没有保险的人群是性传播感染风险较高的关键人群.深圳市生殖道耐药菌流行率较高。随着教育水平降低和没有健康保险,人源支原体的检测显着增加,它与细菌性阴道病或附睾炎有关,表明人马值得进一步关注。
UNASSIGNED: This
study aims to determine the etiological, sociodemographic, and clinical characteristics of STIs, and the level of resistance in M. genitalium in Shenzhen, a representative first-tier city of southern China.
UNASSIGNED: A multicenter cross-sectional
study was conducted and 7886 sexually active participants attending STI-related departments were involved from 22 hospitals. Nine STI-related organisms including N. gonorrhoeae, C. trachomatis, T. vaginalis, M. genitalium, HSV-1, HSV-2, M. hominis, U. parvum, and U. urealyticum were screened.
UNASSIGNED: Being single or divorced was associated with increased detection of N. gonorrhoeae, C. trachomatis, M. genitalium, HSV-1, HSV-2 and M. hominis. Lower education level was associated with increased detection of C. trachomatis, HSV-2 and M. hominis. No insurance coverage was an independent risk factor for T. vaginalis, M. hominis and U. parvum positivity. Three resistance-determining regions related to macrolide and fluoroquinolone were sequenced in 154 M. genitalium positive samples, among which 90.3% harbored mutations related to macrolide or fluroquinolone resistance and 67.5% were multidrug-resistant M. genitalium. A2072G in 23S rRNA and Ser83Ile in parC were the most common mutations. M. hominis was associated with manifestations of bacterial vaginosis in female and epididymitis in male.
UNASSIGNED: Single or divorced individuals, those with lower education level and individuals without insurance are higher-risk key populations for STIs. The prevalence of antimicrobial-resistant M. genitalium in Shenzhen is high. Detection of M. hominis increased significantly with lower education level and no health insurance coverage, and it is associated with bacterial vaginosis or epididymitis, indicating that M. hominis deserves further attention.