METHODS: The study population consisted of 30-year-old women attending maternity care, and 50 year-old men and women attending health check-ups, from 1975 to 2018. Antibody status was determined by multiplex serology and quantified using median reporter fluorescence intensity (MFI).
RESULTS: A total of 891 samples were analysed (519 from 30-year-old women, 186 from 50 year-old women and 186 from 50 year-old men). Of these, 41.5% showed seropositivity for Chlamydia trachomatis, 16.7% for Mycoplasma genitalium, 70.5% for HSV-1, 14.9% for HSV-2, 13.2% for high-risk HPV, and 8.3% for low-risk HPV. Seropositivity for Mycoplasma genitalium, HSV-1 and especially Chlamydia trachomatis decreased over time.
CONCLUSIONS: There was a decrease over time in Chlamydia trachomatis seroprevalence, probably due to contact tracing, testing and early treatment; this might also have affected Mycoplasma genitalium seroprevalence. Despite the reduction, seroprevalences are still high, so continued and new efforts to reduce STI incidence are essential.
方法:研究人群包括30岁的产妇,和50岁的男人和女人参加健康检查,从1975年到2018年。通过多重血清学测定抗体状态,并使用中值报告荧光强度(MFI)定量。
结果:共分析了891个样本(519个来自30岁女性,50岁女性186人,50岁男性186人)。其中,41.5%的沙眼衣原体呈血清阳性,生殖支原体为16.7%,HSV-1占70.5%,HSV-2占14.9%,高危HPV占13.2%,低危型HPV为8.3%。生殖支原体血清阳性,HSV-1,尤其是沙眼衣原体随时间减少。
结论:沙眼衣原体血清阳性率随时间下降,可能是由于接触者追踪,检测和早期治疗;这也可能影响生殖支原体血清阳性率。尽管减少了,血清效价仍然很高,因此,持续和新的努力来减少性传播感染发病率至关重要。