PDF(Pubmed)
Abstract：
BACKGROUND: Sexually transmitted infections (STIs) may cause substantial individual suffering and a large economic burden for society. This study examined the seroprevalence of Chlamydia trachomatis, Mycoplasma genitalium, herpes simplex virus (HSV) types 1 and 2, and several human papillomaviruses (HPV) in the Swedish population over time.
METHODS: The study population consisted of 30-year-old women attending maternity care, and 50 year-old men and women attending health check-ups, from 1975 to 2018. Antibody status was determined by multiplex serology and quantified using median reporter fluorescence intensity (MFI).
RESULTS: A total of 891 samples were analysed (519 from 30-year-old women, 186 from 50 year-old women and 186 from 50 year-old men). Of these, 41.5% showed seropositivity for Chlamydia trachomatis, 16.7% for Mycoplasma genitalium, 70.5% for HSV-1, 14.9% for HSV-2, 13.2% for high-risk HPV, and 8.3% for low-risk HPV. Seropositivity for Mycoplasma genitalium, HSV-1 and especially Chlamydia trachomatis decreased over time.
CONCLUSIONS: There was a decrease over time in Chlamydia trachomatis seroprevalence, probably due to contact tracing, testing and early treatment; this might also have affected Mycoplasma genitalium seroprevalence. Despite the reduction, seroprevalences are still high, so continued and new efforts to reduce STI incidence are essential.
METHODS: The study population consisted of 30-year-old women attending maternity care, and 50 year-old men and women attending health check-ups, from 1975 to 2018. Antibody status was determined by multiplex serology and quantified using median reporter fluorescence intensity (MFI).
RESULTS: A total of 891 samples were analysed (519 from 30-year-old women, 186 from 50 year-old women and 186 from 50 year-old men). Of these, 41.5% showed seropositivity for Chlamydia trachomatis, 16.7% for Mycoplasma genitalium, 70.5% for HSV-1, 14.9% for HSV-2, 13.2% for high-risk HPV, and 8.3% for low-risk HPV. Seropositivity for Mycoplasma genitalium, HSV-1 and especially Chlamydia trachomatis decreased over time.
CONCLUSIONS: There was a decrease over time in Chlamydia trachomatis seroprevalence, probably due to contact tracing, testing and early treatment; this might also have affected Mycoplasma genitalium seroprevalence. Despite the reduction, seroprevalences are still high, so continued and new efforts to reduce STI incidence are essential.
摘要：
背景：性传播感染（STIs）可能会给个人带来巨大的痛苦和社会的巨大经济负担。这项研究检查了沙眼衣原体的血清阳性率，生殖支原体，随着时间的推移，瑞典人群中的单纯疱疹病毒（HSV）1型和2型以及几种人乳头瘤病毒（HPV）。
方法：研究人群包括30岁的产妇，和50岁的男人和女人参加健康检查，从1975年到2018年。通过多重血清学测定抗体状态,并使用中值报告荧光强度(MFI)定量。
结果：共分析了891个样本（519个来自30岁女性，50岁女性186人，50岁男性186人）。其中,41.5%的沙眼衣原体呈血清阳性，生殖支原体为16.7%，HSV-1占70.5%，HSV-2占14.9%，高危HPV占13.2%，低危型HPV为8.3%。生殖支原体血清阳性，HSV-1，尤其是沙眼衣原体随时间减少。
结论：沙眼衣原体血清阳性率随时间下降，可能是由于接触者追踪,检测和早期治疗；这也可能影响生殖支原体血清阳性率。尽管减少了,血清效价仍然很高，因此，持续和新的努力来减少性传播感染发病率至关重要。
方法：研究人群包括30岁的产妇，和50岁的男人和女人参加健康检查，从1975年到2018年。通过多重血清学测定抗体状态,并使用中值报告荧光强度(MFI)定量。
结果：共分析了891个样本（519个来自30岁女性，50岁女性186人，50岁男性186人）。其中,41.5%的沙眼衣原体呈血清阳性，生殖支原体为16.7%，HSV-1占70.5%，HSV-2占14.9%，高危HPV占13.2%，低危型HPV为8.3%。生殖支原体血清阳性，HSV-1，尤其是沙眼衣原体随时间减少。
结论：沙眼衣原体血清阳性率随时间下降，可能是由于接触者追踪,检测和早期治疗；这也可能影响生殖支原体血清阳性率。尽管减少了,血清效价仍然很高，因此，持续和新的努力来减少性传播感染发病率至关重要。
