■脑膜黑素细胞瘤是起源于神经嵴来源的黑素细胞的罕见肿瘤。它们通常是孤立的,多灶性脑膜黑素细胞瘤非常罕见,表明可能更具攻击性的行为。本病例报告和范围审查旨在评估演示文稿,和关键的放射学特征可以帮助区分多灶性脑膜黑素细胞瘤与其他差异,并在诊断这些肿瘤后提供关键管理和预后要点的讨论。
■一名26岁的男性表现为双肩颈部疼痛和左肩运动时主观无力。MRI显示C2-C3硬膜内-髓外病变大增强,T7/T8级进一步病变,左桥小脑角和中线视交叉上区。虽然最初认为影像学表现表明是NF2相关的神经鞘瘤病,宫颈肿瘤的手术切除证实了软脑膜起源的黑素细胞肿瘤,与多灶性脑膜黑素细胞瘤一致。患者术后恢复良好,并保持半年的放射学监测,术后6个月重复MRI显示未经治疗的颅内和脊柱病变的细微生长。
■这是第一个描述,根据我们的知识,与桥小脑角和鞍上病变相关的多灶性脑膜黑素细胞瘤。此病例和纳入的范围检查检查强调,每当遇到多灶性颅脑脊髓病变时,都需要考虑这种罕见的诊断。一旦诊断出这些肿瘤,就需要考虑通过手术切除和辅助颅脊放射治疗进行积极的治疗。
UNASSIGNED: Leptomeningeal melanocytomas are rare tumours originating from neural crest derived melanocytes. They are usually solitary and presentation with
multifocal meningeal melanocytoma is very rare and indicative of potentially more aggressive behaviour. This
case report and scoping review sought to evaluate the presentation, and key radiological features that can help differentiate
multifocal meningeal melanocytoma from other differentials and provide a discussion of the key management and prognostic points once these tumours are diagnosed.
UNASSIGNED: A 26 year old male presented with neck pain radiating to both shoulders and subjective weakness in left shoulder movement. MRI demonstrated a large enhancing C2-C3 intradural-extramedullary lesion with further lesions at the T7/T8 level, left cerebellopontine angle and midline suprachiasmatic region. Whilst the imaging appearances were initially thought be indicative of a phacomatosis such as NF2-related schwannomatosis, surgical excision of the cervical tumour confirmed a melanocytic tumour of leptomeningeal origin, consistent with multifocal meningeal melanocytoma. Patient made a good post-operative recovery and remains under half yearly radiological surveillance, with repeat MRI 6 months after surgery demonstrating subtle growth of the untreated intracranial and spinal lesions.
UNASSIGNED: This is the first description, to our knowledge, of a
multifocal meningeal melanocytoma associated with both cerebellopontine angle and suprasellar lesions. This
case and included scoping review highlight the need to consider this rare diagnosis whenever
multifocal craniospinal lesions are encountered, and the need to consider aggressive management through surgical resection and adjuvant craniospinal radiotherapy once these tumours are diagnosed.