未经批准:李,CJ和Nicoll,JX.丝裂原活化蛋白激酶磷酸化对抵抗运动的时程评估:系统评价。JStrengthCondResXX(X):000-000,2022-抗阻运动(RE)可以增加丝裂原活化蛋白激酶(MAPKs)的信号活动,特别是细胞外信号调节激酶1/2(ERK1/2),p90核糖体S6激酶(p90RSK),c-JunNH2末端激酶(JNK),和p38-MAPK。这些RE诱导的反应有助于调节骨骼肌生长和发育的各种细胞内过程,在阻力训练适应中起着至关重要的作用。MAPK磷酸化到不同RE条件的时程,如培训经验和不同的负载,仍然模棱两可。进行了系统评价以确定不同的RE后恢复时间点对MAPK信号传导级联的影响。此外,还研究了加载和训练状态对MAPK应答的影响.根据系统综述和荟萃分析指南的首选报告项目进行综述,并进行了纳入3个电子数据库的文献检索。使用Downs和Black清单的修改版本来评估研究的方法学质量。在紧接RE后和>RE后6小时之间的时间范围内测量信号传导响应。44项研究符合纳入标准,所有这些都被归类为良好至中等的方法学质量。丝裂原活化蛋白激酶磷酸化水平在RE后不同程度增加,最高的接近停止运动。尽管整体信号在受过训练的个体中减弱,可能是由于训练适应,更高的MAPK反应可归因于65-85%1RM的中等负荷,无论培训经验如何。然而,特定的训练引起的反应仍然模棱两可,和进一步的调查需要确定理想的训练参数,以优化合成代谢肌内信号,这可能会优化阻力训练适应。
UNASSIGNED: Lee, CJ and Nicoll, JX. Time course evaluation of mitogen-activated protein kinase phosphorylation to resistance exercise: a systematic
review. J Strength Cond Res 37(3): 710-725, 2023-Resistance exercise (RE) can increase the signaling activities of mitogen-activated protein kinases (MAPKs), specifically extracellular signal-regulated kinases 1/2 (ERK1/2), p90 ribosomal S6 kinases (p90RSK), c-Jun NH2-terminal kinases (JNK), and p38-MAPK. These RE-induced responses contribute to various intracellular processes modulating growth and development in skeletal muscles, playing an essential role in resistance training adaptations. The time course of MAPK phosphorylation to different RE conditions, such as training experience and varying loads, remains ambiguous. A systematic
review was conducted to determine the effects of different post-RE recovery time points on the MAPK signaling cascade. In addition, the effects of loading and training statuses on MAPK responses were also investigated. The
review was performed according to the preferred reporting items for systematic reviews and meta-analyses guidelines with a literature search incorporating 3 electronic databases. A modified version of the Downs and Black checklist was used to evaluate the methodological quality of the studies. The signaling responses were measured within a time range between immediately post-RE and >6 hours post-RE. Forty-four studies met the inclusion criteria, and all were classified as good-to-moderate methodological quality. Mitogen-activated protein kinase phosphorylation increased to different levels after RE, with the highest near the cessation of exercise. Although overall signaling was attenuated among trained individuals likely because of training adaptations, greater MAPK responses can be attributed to moderate loads of 65-85% 1RM regardless of the training experience. However, specific training-induced responses remain equivocal, and further investigations are required to determine the ideal training parameters to optimize anabolic intramuscular signaling, which may likely optimize resistance training adaptations.