%0 Review
%T [Extracellular Signal-regulated Kinase 1/2 Signaling Regulates Cell Invasion:a Review].
%A Ge XY
%A Shao LL
%A Gao XL
%A He RX
%J Zhongguo Yi Xue Ke Xue Yuan Xue Bao
%V 45
%N 1
%D Feb 2023
%M 36861170
暂无%R 10.3881/j.issn.1000-503X.14640
%X Extracellular signal-regulated kinase 1/2 (ERK1/2) is a serine/threoninekinase involved in the signal transduction cascade of Ras-Raf-mitogen-activated protein kinase (MEK)-ERK.It participates in the cell growth,proliferation and even invasion by regulating gene transcription and expression.The occurrence of a variety of diseases such as lung cancer,liver cancer,ovarian cancer,cervical cancer,endometriosis,and preeclampsia,as well the metastasis and disease progression,is closely associated with the regulation of cell invasion by ERK1/2 signaling pathway.Therefore,exploring the regulation of ERK1/2 signaling on cell invasion and its role in pathogenesis of diseases may help to develop more effective treatment schemes.This article introduces recent progress in the regulation of ERK1/2 signaling on cell invasion and the role of such regulation in diseases,with a view to give new insights into the clinical treatment of ERK 1/2-related diseases.