Minimally invasive surgical procedures

微创外科手术
  • 文章类型: Journal Article
    背景:微创经颈食管切除术是一种无需经胸途径即可提供根治性食管切除术的外科技术。这项研究的目的是评估微创经颈食管切除术的安全性和可行性,并在西方队列中报告该技术的改进。
    方法:单中心前瞻性队列研究设计为IDEAL2A期研究。食管癌患者(cT1b-4aN0-3M0)计划进行食管切除术并有治愈意向,符合纳入研究的条件。主要结局参数是术后肺部并发症发生率,次要结局是吻合口漏,喉返神经麻痹,和R0切除率,以及淋巴结产量。
    结果:总计,在2021年1月至2023年11月期间,75例患者接受了微创经颈食管切除术。对手术技术进行了一些修改,评估,并在理想阶段2A的背景下实施。共有12例患者(16%)发生术后肺部并发症,包括肺炎(4例)和胸腔积液伴引流或抽吸(8例)。75例患者中有33例(44%)出现喉返神经麻痹,33例患者中有30例(91%)康复。75例患者中共有5例(7%)发生吻合口漏。切除淋巴结的中位数为29个(四分位距22-37个),R0切除率为96%(72例)。
    结论:在一家荷兰机构中引入微创经颈食管切除术治疗食管癌与术后肺部并发症发生率低和暂时性喉返神经麻痹发生率高相关。
    BACKGROUND: Minimally invasive transcervical oesophagectomy is a surgical technique that offers radical oesophagectomy without the need for transthoracic access. The aim of this study was to evaluate the safety and feasibility of the minimally invasive transcervical oesophagectomy procedure and to report the refinement of this technique in a Western cohort.
    METHODS: A single-centre prospective cohort study was designed as an IDEAL stage 2A study. Patients with oesophageal cancer (cT1b-4a N0-3 M0) who were scheduled for oesophagectomy with curative intent were eligible for inclusion in the study. The main outcome parameter was the postoperative pulmonary complication rate and the secondary outcomes were the anastomotic leakage, recurrent laryngeal nerve palsy, and R0 resection rates, as well as the lymph node yield.
    RESULTS: In total, 75 patients underwent minimally invasive transcervical oesophagectomy between January 2021 and November 2023. Several modifications to the surgical technique were registered, evaluated, and implemented in the context of IDEAL stage 2A. A total of 12 patients (16%) had postoperative pulmonary complications, including pneumonia (4 patients) and pleural effusion with drainage or aspiration (8 patients). Recurrent laryngeal nerve palsy was observed in 33 of 75 patients (44%), with recovery in 30 of 33 patients (91%). A total of 5 of 75 patients (7%) had anastomotic leakage. The median number of resected lymph nodes was 29 (interquartile range 22-37) and the R0 resection rate was 96% (72 patients).
    CONCLUSIONS: Introducing minimally invasive transcervical oesophagectomy for oesophageal cancer in a Dutch institution is associated with a low rate of postoperative pulmonary complications and a high rate of temporary recurrent laryngeal nerve palsy.
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  • 文章类型: Journal Article
    据报道,保留乳头的乳房切除术(NSM)中的肿胀会通过损害皮瓣和乳头-乳晕复合体的血流而增加坏死的风险。在我们的机构,我们引入了使用达芬奇单端口系统的无肿胀机器人NSM(直观的手术,Inc.).
    我们对2020年10月至2023年3月在Asan医疗中心接受无肿胀机器人NSM的患者进行了回顾性分析(首尔,韩国)。临床病理特征,不良事件,评估手术时间。
    在研究期间,118例患者接受了无肿胀机器人NSM。31例患者(26.3%)发生不良事件。根据Clavien-Dindo分类,五名患者(4.2%)被分类为III级,需要手术。自体组织重建的平均总手术时间为467分钟(n=49),植入物的平均总手术时间为252分钟(n=69)。累计手术例数与乳腺手术时间无相关性(术者A,P=0.30,0.52,0.59,B,C)为3名外科医生。然而,观察到显著的线性关系(P<0.001),标本重量每增加100-g,手术时间增加13分钟。
    无肿胀机器人NSM是一种安全的程序,具有可行的手术时间和很少的不良事件。
    UNASSIGNED: Tumescent in nipple-sparing mastectomy (NSM) has been reported to increase the risk of necrosis by impairing blood flow to the skin flap and nipple-areolar complex. At our institution, we introduced a tumescent-free robotic NSM using the da Vinci single-port system (Intuitive Surgical, Inc.).
    UNASSIGNED: We conducted a retrospective analysis of patients who underwent tumescent-free robotic NSM between October 2020 and March 2023 at Asan Medical Center (Seoul, Korea). Clinicopathological characteristics, adverse events, and operative time were evaluated.
    UNASSIGNED: During the study period, 118 patients underwent tumescent-free robotic NSM. Thirty-one patients (26.3%) experienced an adverse event. Five patients (4.2%) were classified as grade III based on the Clavien-Dindo classification and required surgery. The mean total operative time was 467 minutes for autologous tissue reconstruction (n = 49) and 252 minutes for implants (n = 69). No correlation was found between the cumulative number of surgical cases and the breast operative time (P = 0.30, 0.52, 0.59 for surgeons A, B, C) for the 3 surgeons. However, a significant linear relationship (P < 0.001) was observed, with the operative time increasing by 13 minutes for every 100-g increase in specimen weight.
    UNASSIGNED: Tumescent-free robotic NSM is a safe procedure with a feasible operative time and few adverse events.
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  • 文章类型: Journal Article
    背景:微创经皮钢板内固定治疗肱骨干骨折(HSF)由于复位不良和辐射暴露而存在局限性。为了解决这些限制,我们集成了机器人和3D打印结合板作为减少模板。
    方法:创新技术使用18种带有皮质标记孔的模型,促进了手术室中HSF的封闭式减少。将预成型板的数据集导入三维规划软件进行虚拟固定和螺钉路径规划。将模型分成两半以模拟横向骨折。在操作过程中,软件生成的机器人导航钻孔轨迹,和精确的钢板安装实现了自动骨折复位。
    结果:降低精度的评估结果显示长度变化,并置,对齐,和符合解剖复位标准的旋转。对于所有参数都观察到高操作员间可靠性。
    结论:所提出的技术实现了模拟骨骼的解剖还原。
    BACKGROUND: Minimally invasive percutaneous plate osteosynthesis for humeral shaft fractures (HSFs) has limitations due to malreduction and radiation exposure. To address these limitations, we integrated robotics and 3D printing by incorporating plates as reduction templates.
    METHODS: The innovative technology facilitated closed reduction of HSFs in the operating theatre using 18 models with cortical marking holes. The dataset of the precontoured plate was imported into 3D planning software for virtual fixation and screw path planning. The models were divided into half to simulate transverse fractures. During the operation, the software generated drilling trajectories for robot navigation, and precise plate installation achieved automatic fracture reduction.
    RESULTS: The evaluation results of reduction accuracy revealed variations in length, apposition, alignment, and rotation that meet the criteria for anatomic reduction. High interoperator reliabilities were observed for all parameters.
    CONCLUSIONS: The proposed technology achieved anatomic reduction in simulated bones.
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  • 文章类型: Journal Article
    机器人辅助的微创直接冠状动脉搭桥术(RA-MIDCAB)是冠状动脉血运重建的一种有吸引力的策略。越来越多的证据支持在冠状动脉手术中使用全动脉移植。我们使用RA-MIDCAB评估了双侧胸廓内动脉(BITA)的总动脉左侧冠状动脉血运重建,并将其与倾向评分匹配(PSM)非体外循环CAB(OPCAB)手术人群进行了比较。
    我们回顾性纳入了2015年1月1日至2022年10月31日使用BITA进行的所有孤立的OPCAB和RA-MIDCAB手术,而没有进行大隐静脉移植。我们分析了所有RA-MIDCAB患者,并进行了PSM,以将其与我们的OPCAB人群进行比较。主要结局是主要不良心脑血管事件(MACCE)和死亡率。次要结果是手术参数,住院时间,和学习曲线。
    我们包括601OPCAB和77RA-MIDCAB程序,这导致2个队列的54名患者PSM后。死亡率和MACCE生存分析显示无显著差异。与OPCAB组(38.9%;P=0.02)相比,RA-MIDCAB组的输血减少(16.7%)。我们观察到重症监护病房(ICU)入院人数减少(24.1%vs96.6%),ICU住院时间较短(0.78±1.7vs1.91±1.01天),RA-MIDCAB与OPCAB组的住院时间较短(6.78±2.4vs8.01±2.5天)(P<0.01)。手术时间从400.0±70.8降至325.0±38.0min,RA-MIDCABBITA采集经验更多(P<0.01)。
    这是用于左冠状动脉系统血运重建的77份连续RA-MIDCABBITA采集的第一份出版物。该技术在MACCE和死亡率方面是安全的。其他优点是住院时间短,ICU入院人数减少,减少输血。
    UNASSIGNED: Robot-assisted minimally invasive direct coronary artery bypass (RA-MIDCAB) is an attractive strategy for coronary revascularization. Growing evidence supports the use of total arterial grafting in coronary surgery. We evaluated total arterial left-sided coronary revascularization with bilateral internal thoracic artery (BITA) using RA-MIDCAB and compared it with a propensity score-matched (PSM) off-pump CAB (OPCAB) surgery population.
    UNASSIGNED: We retrospectively included all isolated OPCAB and RA-MIDCAB surgery using BITA without saphenous vein graft from January 1, 2015, to October 31, 2022. We analyzed all our RA-MIDCAB patients and performed PSM to compare them with our OPCAB population. Primary outcomes were major adverse cardiovascular and cerebrovascular events (MACCE) and mortality. Secondary outcomes were surgical parameters, length of hospital stay, and learning curve.
    UNASSIGNED: We included 601 OPCAB and 77 RA-MIDCAB procedures, which resulted in 2 cohorts of 54 patients after PSM. Mortality and MACCE survival analysis showed no significant difference. There was less blood transfusion in the RA-MIDCAB (16.7%) compared with the OPCAB group (38.9%; P = 0.02). We observed fewer intensive care unit (ICU) admissions (24.1% vs 96.6%), shorter ICU stay (0.78 ± 1.7 vs 1.91 ± 1.01 days), and shorter hospital stay (6.78 ± 2.4 vs 8.01 ± 2.5 days) in the RA-MIDCAB versus OPCAB group (P < 0.01). Surgery time decreased from 400.0 ± 70.8 to 325.0 ± 38.0 min with more experience in RA-MIDCAB BITA harvesting (P < 0.01).
    UNASSIGNED: This is a first publication of 77 consecutive RA-MIDCAB BITA harvesting for left coronary artery system revascularization. This technique is safe in terms of MACCE and mortality. Additional advantages are shorter length of hospital stay, fewer ICU admissions, and less blood transfusion.
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  • 文章类型: Journal Article
    上半胸骨切开术是微创左心室辅助装置植入中流出移植物与升主动脉吻合的常用方法。也可以使用右胸小切开术,但是机器人辅助的使用只有轶事的报道。我们研究的目的是确认机器人辅助缝合流出移植物吻合术的可行性,并评估机器人缝合部分的性能指标。该程序由两名外科医生在八具尸体研究中进行。辅助装置泵头通过左侧小切口插入,流出移植物通过心包流向右侧第二间隙小切口。在升主动脉上放置部分闭塞钳后,进行了纵向主动脉切开术,并通过机器人进行了流出移植到升主动脉的吻合。该程序在所有八次尝试中都是可行的。平均流出移植物吻合时间为20.1(SD6.8)分钟,平均外科医生完成吻合的信心和舒适度分别为8.3(SD2.4)和6.9(SD2.2),分别,十级李克特量表。在对吻合口进行开放式检查时,在所有情况下都有良好的缝线对齐。我们得出的结论是,在良好的外科医生舒适度下,将左心室辅助装置流出移植物缝合到人升主动脉是非常可行的。吻合时间是可接受的,并且可以在适当对齐的情况下进行缝线放置。
    Upper hemi-sternotomy is a common approach for outflow graft anastomosis to the ascending aorta in minimally invasive left-ventricular assist device implantation. Right mini-thoracotomy may also be used, but use of robotic assistance has been reported only anecdotally. The aim of our study was to confirm the feasibility of robotically assisted suturing of the outflow graft anastomosis and to assess performance metrics for the robotic suturing part of the procedure. The procedure was carried out in eight cadaver studies by two surgeons. The assist device pump head was inserted through a left-sided mini-thoracotomy and the outflow graft was passed toward a right-sided second interspace mini-thoracotomy through the pericardium. After placement of a partial occlusion clamp on the ascending aorta, a longitudinal aortotomy was performed and the outflow graft to ascending aorta anastomosis was carried out robotically. The procedure was feasible in all eight attempts. The mean outflow graft anastomotic time was 20.1 (SD 6.8) min and the mean surgeon confidence and comfort levels to complete the anastomoses were 8.3 (SD 2.4) and 6.9 (SD2.2), respectively, on a ten-grade Likert scale. On open inspection of the anastomoses, there was good suture alignment in all cases. We conclude that suturing of a left-ventricular assist device outflow graft to the human ascending aorta is very feasible with good surgeon comfort. Anastomotic times are acceptable and suture placement can be performed with appropriate alignment.
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  • 文章类型: Journal Article
    目的比较腰椎微创减压手术患者术前、术后焦虑和抑郁的症状,分析焦虑与术后临床疗效的关系.方法对接受微创腰椎减压手术的患者进行前瞻性队列研究。使用视觉模拟量表(VAS)测量手术前和手术后6个月的临床结果,全球感知变化效应(GPE),医院焦虑和抑郁量表(HADS),和Oswestry残疾指数(ODI)。根据术前焦虑评分,患者分为焦虑和非焦虑患者,并对结果进行了比较。结果两组患者的临床结局评估结果相似。两种焦虑患者术前HADS评分均在术后6个月内显著下降(8.70±3.48vs.5.75±3.91)和抑郁(6.95±3.54vs.5.50±2.99)。背部(-2.8±3.64)和腿部(-5.5±3.5)的VAS量表显示疼痛减轻。结论微创腰椎减压术促进临床及功能改善,不受术前焦虑症状的影响。心理健康指标显示术后6个月症状明显减轻。
    Objective  To analyze associations between anxiety and postsurgical clinical outcomes in patients who underwent minimally invasive lumbar decompression surgery in addition to comparing symptoms of anxiety and depression before and after surgery. Methods  This prospective cohort study of patients who underwent minimally invasive lumbar decompression surgery. Clinical outcomes were measured before and 6 months after surgery using the Visual Analog Scale (VAS), Global Perceived Effect of Change (GPE), Hospital Anxiety and Depression Scale (HADS), and Oswestry Disability Index (ODI). Based on the presurgical anxiety score, patients were categorized into anxious and non-anxious patients, and the outcomes were compared. Results  The patients of both groups obtained similar results concerning the clinical outcomes evaluated. Preoperative HADS scores decreased significantly 6 months after surgery in both anxiety (8.70 ± 3.48 vs. 5.75 ± 3.91) and depression (6.95 ± 3.54 vs. 5.50 ± 2.99). The VAS scale for the back (-2.8 ± 3.64) and legs (-5.5 ± 3.5) showed a reduction in pain. Conclusion  Minimally invasive lumbar decompression surgery promoted clinical and functional improvement, not being affected by preoperative anxiety symptoms. Mental health indicators showed a significant reduction in symptoms 6 months after surgery.
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  • 文章类型: Journal Article
    目的:关于长期严重骶髂关节痛的微创骶髂关节融合术后的治疗结果存在矛盾的证据。我们队列研究的主要目的是在瑞典脊柱注册中心的日常实践中调查微创骶髂关节手术后患者报告的结果指标(PROM)的变化。次要目的是探索达到患者可接受症状评分(PASS)的患者比例和疼痛评分的最小临床重要差异(MCID)。物理功能,以及与健康相关的生活质量结果;此外,评估自我报告的满意度,步行距离,以及病假/残疾假患者比例的变化,并报告并发症和再次手术。
    方法:从瑞典脊柱登记处收集首次骶髂关节融合患者的数据,21至70岁,术前可用的PROM,在最后一次手术后1年或2年。项目包括Oswestry残疾指数(ODI),下腰痛(LBP)和腿部疼痛的数字评定量表(NRS),和EQ-VAS,除了人口统计变量。我们计算了从术前到术后的平均变化以及达到MCID和PASS的患者比例。
    结果:68例患者有可用的术前和术后数据,平均年龄45岁(25-70岁)和59岁(87%)为女性。随访时,LBP平均降低2.3个NRS点(95%置信区间[CI]1.6-2.9;P<0.001),ODI平均降低14.8点(CI10.6-18.9;P<0.001)。随访时EQ-VAS评分提高22分(CI15.4-30.3,P<0.001)。大约一半的患者在疼痛方面达到了MCID和PASS(MCIDNRSLBP:38/65[59%]和PASSNRSLBP:32/66[49%])和身体功能(MCIDODI:27/67[40%]和PASSODI:24/67[36%])。随访时增加患者步行距离超过1km的几率为3.5(CI1.8-7.0;P<0.0001),休完全病假或完全残疾假的人数为0.57(CI0.4-0.8;P=0.001)。在手术后的前3个月,报告了3种并发症,并在后续阶段进行2次再手术。
    结论:我们发现微创骶髂关节融合术在日常实践中应用时,治疗效果中等,疼痛中度缓解,身体功能略有改善。
    OBJECTIVE: There is conflicting evidence regarding treatment outcomes after minimally invasive sacroiliac joint fusion for long-lasting severe sacroiliac joint pain. The primary aim of our cohort study was to investigate change in patient-reported outcome measures (PROMs) after minimally invasive sacroiliac joint surgery in daily practice in the Swedish Spine Registry. Secondary aims were to explore the proportion of patients reaching a patient acceptable symptom score (PASS) and the minimal clinically important difference (MCID) for pain scores, physical function, and health-related quality of life outcomes; furthermore, to evaluate self-reported satisfaction, walking distance, and changes in proportions of patients on full sick leave/disability leave and report complications and reoperations.
    METHODS: Data from the Swedish Spine Registry was collected for patients with first-time sacroiliac joint fusion, aged 21 to 70 years, with PROMs available preoperatively, at 1 or 2 years after last surgery. PROMs included Oswestry Disability Index (ODI), Numeric Rating Scale (NRS) for low back pain (LBP) and leg pain, and EQ-VAS, in addition to demographic variables. We calculated mean change from pre- to postoperative and the proportion of patients achieving MCID and PASS.
    RESULTS: 68 patients had available pre- and postoperative data, with a mean age of 45 years (range 25-70) and 59 (87%) were female. At follow-up the mean reduction was 2.3 NRS points (95% confidence interval [CI] 1.6-2.9; P < 0.001) for LBP and 14.8 points (CI 10.6-18.9; P < 0.001) for ODI. EQ-VAS improved by 22 points (CI 15.4-30.3, P < 0.001) at follow-up. Approximately half of the patients achieved MCID and PASS for pain (MCID NRS LBP: 38/65 [59%] and PASS NRS LBP: 32/66 [49%]) and physical function (MCID ODI: 27/67 [40%] and PASS ODI: 24/67 [36%]). The odds for increasing the patient\'s walking distance to over 1 km at follow-up were 3.5 (CI 1.8-7.0; P < 0.0001), and of getting off full sick leave or full disability leave was 0.57 (CI 0.4-0.8; P = 0.001). In the first 3 months after surgery 3 complications were reported, and in the follow-up period 2 reoperations.
    CONCLUSIONS: We found moderate treatment outcomes after minimally invasive sacroiliac joint fusion when applied in daily practice with moderate pain relief and small improvements in physical function.
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  • 文章类型: Journal Article
    治疗复发性腹股沟疝很复杂,并选择正确的手术方法(腹腔镜与开放)对患者预后至关重要。这项研究比较了使用相同与初始和后续疝修补的不同手术方法。
    我们回顾性分析了2014年1月至2023年5月在首尔国立大学Bundang医院接受复发性腹股沟疝修补术的患者。患者分为“一致”和“不一致”组,包括在两种手术中接受相同和不同方法的患者,分别。术前基线特征,索引手术数据,术后结果,并对复发率进行分析比较。
    总共,入选131例患者;一致和不一致组包括31例(开放,n=19;腹腔镜,n=12)和100例患者(开放至腹腔镜,n=68;腹腔镜开腹,n=32),分别。在平均手术时间(50.5±21.7分钟与50.2±20.0分钟,P=0.979),并发症发生率(6.5%vs.14.0%,P=0.356),或36个月累积复发率(9.8%vs.9.8%;P=0.865)。不一致组的平均术后住院时间明显短于一致组(1.8±0.7vs.1.4±0.6,P=0.003)。
    大多数复发性腹股沟疝修补术采用不一致的手术入路进行。总的来说,手术入路的一致性对术后结局无显著影响.因此,根据患者的病情和外科医生的偏好选择手术方式可能是明智的。
    UNASSIGNED: Managing recurrent inguinal hernias is complex, and choosing the right surgical approach (laparoscopic vs. open) is vital for patient outcomes. This study compared the outcomes of using the same vs. different surgical approaches for initial and subsequent hernia repairs.
    UNASSIGNED: We retrospectively analyzed patients who underwent recurrent inguinal hernia repair at Seoul National University Bundang Hospital between January 2014 and May 2023. Patients were divided into the \"concordant\" and \"discordant\" groups, comprising patients who underwent same and different approaches in both surgeries, respectively. Preoperative baseline characteristics, index surgery data, postoperative outcomes, and recurrence rates were analyzed and compared.
    UNASSIGNED: In total, 131 patients were enrolled; the concordant and discordant groups comprised 31 (open, n = 19; laparoscopic, n = 12) and 100 patients (open to laparoscopic, n = 68; laparoscopic to open, n = 32), respectively. No significant differences were observed in the mean operation time (50.5 ± 21.7 minutes vs. 50.2 ± 20.0 minutes, P = 0.979), complication rates (6.5% vs. 14.0%, P = 0.356), or 36-month cumulative recurrence rates (9.8% vs. 9.8%; P = 0.865). The mean postoperative hospital stay was significantly shorter in the discordant than in the concordant group (1.8 ± 0.7 vs. 1.4 ± 0.6, P = 0.003).
    UNASSIGNED: Most recurrent inguinal hernia repairs were performed using the discordant surgical approach. Overall, concordance in the surgical approach did not significantly affect postoperative outcomes. Therefore, the selection of the surgical approach based on the patient\'s condition and surgeon\'s preference may be advisable.
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  • 文章类型: Journal Article
    背景:脑出血(ICH)是一种常见的卒中类型,具有高发病率和高死亡率。治疗ICH的手术方法主要有三种。不幸的是,到目前为止,没有特定的手术方法被证明是最有效的。我们进行了这项研究,以调查与小骨瓣开颅术相比,内镜手术或立体定向抽吸(无框导航抽吸)的微创手术是否会改善幕上ICH患者的功能预后。
    方法:在16个中心进行的平行组多中心随机对照试验中,幕上高血压ICH患者随机接受内镜手术,立体定向抽吸,或开颅手术,从2016年7月到2022年6月,比例为1:1:1。随访6个月。患者随机接受内镜下疏散,立体定向抽吸,或者小骨瓣开颅术.主要结果是有利的功能结果,定义为6个月随访时改良Rankin量表(mRS)评分为0~2分的患者比例.
    结果:总共733例患者被随机分为三组:243例内窥镜检查组,第247号发给愿望小组,243分给开颅手术组。最后,721例患者(内镜组239例,246在抽吸组中,开颅手术组236人)接受治疗并纳入意向治疗分析.初步疗效分析显示,内镜组219人中有73人(33.3%),吸入组中220人中的72人(32.7%),在6个月的随访中,开颅手术组212人中有47人(22.2%)获得了良好的功能结局(P=0.017)。我们在深度出血的亚组分析中得到了类似的结果,而在大叶出血中,三组的预后结果相似。老年,深部血肿位置,血肿体积大,术前GCS评分低,开颅手术,颅内感染与更大的不良结局相关.内窥镜检查组的平均住院费用为92,420日元,¥77,351在抽吸组中,开颅手术组为100,947日元(P=.000)。
    结论:与小骨瓣开颅手术相比,内镜手术和立体定向抽吸术改善了高血压ICH的长期预后,尤其是深度出血.
    背景:ClinicalTrials.gov标识符:NCT02811614。
    BACKGROUND: Intracerebral hemorrhage (ICH) is a common stroke type with high morbidity and mortality. There are mainly three surgical methods for treating ICH. Unfortunately, thus far, no specific surgical method has been proven to be the most effective. We carried out this study to investigate whether minimally invasive surgeries with endoscopic surgery or stereotactic aspiration (frameless navigated aspiration) will improve functional outcomes in patients with supratentorial ICH compared with small-bone flap craniotomy.
    METHODS: In this parallel-group multicenter randomized controlled trial conducted at 16 centers, patients with supratentorial hypertensive ICH were randomized to receive endoscopic surgery, stereotactic aspiration, or craniotomy at a 1:1:1 ratio from July 2016 to June 2022. The follow-up duration was 6 months. Patients were randomized to receive endoscopic evacuation, stereotactic aspiration, or small-bone flap craniotomy. The primary outcome was favorable functional outcome, defined as the proportion of patients who achieved a modified Rankin scale (mRS) score of 0-2 at the 6-month follow-up.
    RESULTS: A total of 733 patients were randomly allocated to three groups: 243 to the endoscopy group, 247 to the aspiration group, and 243 to the craniotomy group. Finally, 721 patients (239 in the endoscopy group, 246 in the aspiration group, and 236 in the craniotomy group) received treatment and were included in the intention-to-treat analysis. Primary efficacy analysis revealed that 73 of 219 (33.3%) in the endoscopy group, 72 of 220 (32.7%) in the aspiration group, and 47 of 212 (22.2%) in the craniotomy group achieved favorable functional outcome at the 6-month follow-up (P = .017). We got similar results in subgroup analysis of deep hemorrhages, while in lobar hemorrhages the prognostic outcome was similar among three groups. Old age, deep hematoma location, large hematoma volume, low preoperative GCS score, craniotomy, and intracranial infection were associated with greater odds of unfavorable outcomes. The mean hospitalization expenses were ¥92,420 in the endoscopy group, ¥77,351 in the aspiration group, and ¥100,947 in the craniotomy group (P = .000).
    CONCLUSIONS: Compared with small bone flap craniotomy, endoscopic surgery and stereotactic aspiration improved the long-term outcome of hypertensive ICH, especially deep hemorrhages.
    BACKGROUND: ClinicalTrials.gov Identifier: NCT02811614.
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  • 文章类型: Journal Article
    背景:先前的研究尚未评估老年患者胰腺远端微创切除术的手术难度。因此,我们旨在探讨高龄对微创胰尾切除术围手术期结局的影响,专注于手术困难。
    方法:这项单中心回顾性研究包括2012年9月至2023年12月在关西罗塞医院接受了胰腺癌微创远端胰腺切除术的患者。调查老年人(>75岁)和非老年人(≤75岁)组之间的围手术期结局。
    结果:56例患者包括:老年组和非老年组26例和30例,分别。老年组的中位手术时间明显短于非老年组(324vs.414分钟,p=.022),但包括肿瘤因素在内的其他手术结局无显著差异.老年人组和非老年人组的中位难度评分相似(6vs.分别为7;p=.699)。老年组和非老年组术后并发症和胰瘘发生率无显著差异(23%vs.43%,p=.159,19%与36%,分别为p=.236),即使在低至中或高难度评分的亚组中进行分析。
    结论:胰腺癌微创远端胰腺切除术的安全性和可行性在老年患者和非老年患者之间无明显差异。即使考虑到手术困难。这种外科手术对于老年患者是安全可行的。
    BACKGROUND: Previous studies have not evaluated the surgical difficulty of minimally invasive distal pancreatectomy for pancreatic cancer in elderly patients. Therefore, we aimed to investigate the effect of elderly age on the perioperative outcomes of minimally invasive distal pancreatectomy, focusing on surgical difficulty.
    METHODS: This single-center retrospective study included patients who underwent minimally invasive distal pancreatectomy for pancreatic cancer at Kansai Rosai Hospital between September 2012 and December 2023. Perioperative outcomes were investigated between the elderly (>75 years) and non-elderly (≤75 years) groups.
    RESULTS: Fifty-six patients were included: 26 and 30 in the elderly and non-elderly groups, respectively. The median operative time was significantly shorter in the elderly group than in the non-elderly group (324 vs. 414 min, p = .022), but other surgical outcomes were not significantly different including oncological factors. The median difficulty score was similar between the elderly and non-elderly groups (6 vs. 7, respectively; p = .699). The incidences of postoperative complications and pancreatic fistulas were not significantly different in the elderly and non-elderly groups (23% vs. 43%, p = .159, and 19% vs. 36%, p = .236, respectively), even though analyzed in subgroups with low-to-intermediate or high difficulty score.
    CONCLUSIONS: The safety and feasibility of minimally invasive distal pancreatectomy for pancreatic cancer were not significantly different between elderly and non-elderly patients, even when surgical difficulty was considered. This surgical procedure can be safe and feasible for elderly patients.
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