目的:本研究旨在评估和对比灼口综合征(BMS-MCI)患者和轻度认知障碍老年患者(G-MCI)的认知和心理方面,关注潜在的预测因素,比如疼痛,情绪障碍,血液生物标志物,和年龄相关的白质变化(ARWMC)。
方法:该研究纳入了40个BMS-MCI和40个老年G-MCI,按年龄进行匹配,性别,和教育背景。参与者接受了心理,困倦,和认知评估,包括迷你精神状态考试(MMSE),跟踪测试(TMT),Corsi块攻丝任务,Rey听觉语言学习测试,复制几何图纸测试,正面评估电池,和数字取消测试。
结果:G-MCI患者在右侧(p=0.005**)和左侧(p<0.001**)颞区表现出更高的ARWMCs评分,这可能与特定的神经退行性过程有关。相反,BMS-MCI患者的抑郁和焦虑水平较高,MMSE评分较低(p<0.001**),还为需要处理速度和执行功能的任务而苦苦挣扎,其更高的TMT-A评分(p<0.001**)证明了这一点。
结论:该研究强调了BMS-MCI在整体认知和处理速度方面的特殊缺陷。受教育背景的影响,疼痛程度,胆固醇,睡眠障碍,这些认知评估中的焦虑强调了对针对MCI的认知和情感方面的个性化治疗策略的需求。
OBJECTIVE: This
study aims to assess and contrast cognitive and psychological aspects of patients with burning mouth syndrome (BMS-MCI) and geriatric patients (G-MCI) with mild cognitive impairment, focusing on potential predictors like pain, mood disorders, blood biomarkers, and age-related white matter changes (ARWMCs).
METHODS: The
study enrolled 40 BMS-MCI and 40 geriatric G-MCI, matching them by age, gender, and educational background. Participants underwent psychological, sleepiness, and cognitive assessment including the Mini-Mental State Exam (MMSE), Trail Making Test (TMT), Corsi Block-Tapping Task, Rey Auditory Verbal Learning Test, Copying Geometric Drawings Test, Frontal Assessment Battery, and Digit Cancellation Test.
RESULTS: G-MCI patients exhibited higher ARWMCs scores in right (p = 0.005**) and left (p < 0.001**) temporal regions, which may relate to specific neurodegenerative processes. Conversely, BMS-MCI patients showed higher levels of depression and anxiety and lower MMSE scores(p < 0.001**), also struggling more with tasks requiring processing speed and executive function, as evidenced by their higher TMT-A scores (p < 0.001**).
CONCLUSIONS: The
study highlights particular deficits in global cognition and processing speed for BMS-MCI. The influence of educational background, pain levels, cholesterol, sleep disturbances, and anxiety on these cognitive assessments underscores the need for personalized therapeutic strategies addressing both cognitive and emotional aspects of MCI.