BACKGROUND: Mutations in one or multiple genes can lead to hypodontia and its characteristic features. Numerous studies have shown a strong genetic influence on the occurrence of hypodontia, and identified several genes, including AXIN2, EDA, FGF3, FGFR2, FGFR10, WNT10A, MSX1, and PAX9, that are directly associated with dental agenesis and carcinogenesis. The objective of this study was to investigate the occurrence and pattern of tooth agenesis, microdontia, and palatally displaced canine (PDC) in women diagnosed with papillary thyroid cancer (PTC), compared to a control group of women without any malignancy or thyroid disease.
METHODS: This case-control study was carried at the Department of Orthodontics, School of Dental Medicine University of Zagreb, and Department of Oncology and Nuclear Medicine Sestre Milosrdnice University Hospital Centre. The study involved a clinical examination and evaluation of dental status, panoramic X-ray analysis, and assessment of medical and family history of 116 female patients aged 20-40 with PTC, as well as 424 females in the control group who were of similar age.
RESULTS: The prevalence of hypodontia, microdontia, and PDC was statistically higher in women with PTC than in the control group. The prevalence rate of hypodontia was 11.3% in the experimental group and 3.5% in the control group. The experimental group showed a higher occurrence of missing upper lateral incisors, lower left central incisors, and all the third molars (except the upper left) compared to the control group. Women with PTC showed the prevalence of PDC significantly higher than the control group (3.5%, 0.7%, p = 0.002). The probability of hypodontia as a clinical finding increases 2.6 times, and microdontia occurs 7.7 times more frequently in women with PTC.
CONCLUSIONS: Our study suggests a possible link between odontogenesis and PTC. The absence of permanent teeth may increase the likelihood of PTC in women. Leveraging the age-7 orthopantomogram to identify women at high risk for PTC within a critical early detection window could significantly improve oral health outcomes and PTC prognosis through proactive interventions.

To investigate the distribution of dental anomalies between non-syndromic orofacial cleft patients and their association with the cleft type and gender.
Retrospective cross-sectional study involving examination of intraoral dental records and radiographs.
300 non-syndromic orofacial cleft patients included (161 males and 139 females, mean age: 10.23 ± 2.3 years).
Variables analyzed: tooth agenesis, microdontia, and supernumerary teeth. Data analysis: Chi-square and Fisher\'s exact tests to investigate the correlation between dental anomalies, cleft type, and gender.
Agenesis occurred in 66% of the subjects, supernumerary teeth in 19.6%, and microdontia in 18.3%. In females with unilateral left cleft lip and palate (CLP), agenesis was significantly higher compared to males. Both genders presented significant agenesis of maxillary lateral incisors and right central incisor. Significant agenesis of central incisor, canine and second premolar on the upper left side and lower second premolars were observed only in males, with significant microdontia for maxillary lateral incisors and left central incisor. Significant agenesis of maxillary first premolars was seen only in females. Agenesis in maxillary quadrants was significant for patients with unilateral right and left CLP, and bilateral CLP. In mandibular quadrants, agenesis was substantially higher for patients with isolated CP.
Results suggest that tooth agenesis and microdontia might not be directly associated with the cleft area\'s anatomical irregularity but are affected by gender and other genetic factors that regulate the development of the anomaly and the orofacial clefting mutually.

OBJECTIVE: To evaluate the presence of developmental dental anomalies, like microdontia, hypodontia, abnormally shaped teeth (AST), and developmental defects of enamel (DDE) in childhood cancer survivors and compare it with the healthy controls.
METHODS: This cross-sectional analytical study was conducted in 2 groups: childhood cancer survivors (CCS) group including children (> 12 y, m/f) who had undergone anticancer therapy (ACT) before 8 y of age and healthy control group (> 12 y, m/f) without any systemic disease. Pearson chi-square test was used to analyze the difference between the CCS group and the control group for microdontia, hypodontia, AST, DDE and for intragroup analysis in CCS group. Odds ratio was also calculated.
RESULTS: A total of 120 and 121 children were included in CCS and control group, respectively. The prevalence of microdontia, hypodontia, abnormally shaped teeth, and DDE was 17.5% (21), 5% (6), 8.33% (10), and 37.5% (45), respectively in CCS group. It was 8.2% (10), 2.5% (3), 1.65% (2), and 22.3% (27), respectively in the control group. A statistically significant difference was seen in microdontia (p = 0.032), abnormally shaped teeth (p = 0.017) and DDE (p = 0.01). Higher prevalence was seen when ACT began at an early age.
CONCLUSIONS: An association between developmental dental anomalies and anticancer therapy (ACT) exists with significantly higher difference in microdontia, abnormally shaped teeth and DDE among survivors of childhood cancer as compared to healthy population. These known adverse effects of ACT on developing teeth should be considered during treatment planning of the children having cancers.

OBJECTIVE: This study aimed to evaluate nonsyndromic developmental dental anomalies (DDAs) in individuals born from consanguineous and nonconsanguineous marriages and the possible effects of these marriages on self-reported systemic diseases.
METHODS: The study comprised a total of 880 patients aged 16 years or older who applied to our clinic for various dental problems. Based on detailed anamnesis, the patients were divided into 2 groups: individuals born from consanguineous (study group, n = 445) and nonconsanguineous (control group, n = 435) marriages. The parents\' consanguinity type was also recorded, as well as the presence of any self-reported systemic diseases. The number, size, erupted, and morphological DDA types were investigated with both clinical and radiological examinations. All data from the 2 groups were recorded, and a statistical analysis was performed.
RESULTS: There was a statistically significant relationship between the consanguineous marriage and the size (microdontia), and morphological (dilaceration and taurodontism) DDA types. Additionally, a significant relationship was found between consanguineous marriage and self-reported systemic disease but not between the parents\' consanguinity type and systemic disease.
CONCLUSIONS: The results of this study suggest that consanguineous marriage affects DDAs.

UNASSIGNED: Hypodontia and hyperdontia may occur with other dental anomalies such as microdontia, taurodontism, talon cusp, macrodontia and germination.
UNASSIGNED: The aim of this study to evaluate the relationship between hypodontia and hyperdontia with taurodontism, macrodontia and microdontia.
UNASSIGNED: In this retrospective study, 2,348 Turkish patients aged 7 to 12 years and treated between 01.01.2017 and 01.01.2018 in Bahcelievler Oral and Dental Health Hospital were evaluated. Data were collected and differences in the distribution of hypodontia and hyperdontia including other dental anomalies were analysed.
UNASSIGNED: Of the total sample of 2,348 patients, 1,126 (48%) were girls, 1,222 (52%) were boys. Hypodontia was found in 177 children (93 girls (53%), 84 boys (47%)). The prevalence of hypodontia and hyperdontia were 7.5% and 0.9%. Taurodontism is the most common dental anomalies in hypodontia patients (39%) followed by microdontia (10%). Taurodontism was more prevalent in girls (42%) than in boys (36.5%). Microdontia was found in 10 patients and macrodontia was observed in 9 hypodontia patients. Hyperdontia was found in 21 children [8 girls (38%), 13 boys (62%)]. The most common supernumerary tooth found was mesiodens (85%) and it\'s more prevalent in boys (67%) than in girls (33%). Taurodontism is the most common dental anomaly (48%) following macrodontia (19%) and were found to be much more prevalent in boys (53%) (23%) than in girls (37.5%) (12.5%). Microdontia was found in only 1 boy (%7.7) in hyperdontia patients.
UNASSIGNED: Hypodontia and hyperdontia with taurodontism, microdontia, and macrodontia need much more complex treatment plan. All cases should be evaluated using interdisciplinary approach for appropriate treatment choice. This helps in longterm and effective treatment planning according to a child\'s individual requirements.

UNASSIGNED: Consanguinity is known to alter the population structure but the available literature is almost silent on the association of dental conditions with consanguinity.
UNASSIGNED: The purpose was to assess the various dental developmental anomalies in 6-9 year old children born out of consanguineous and non-consanguineous marriages and its association with their parents.
UNASSIGNED: A cross sectional house-hold survey with a sample size of 2,000 (1,600 non-consanguineous and 400 consanguineous respondents and their parents) using systematic random sampling was planned. Six to nine-year-old children and their parents living in 1,597 households were examined and the information recorded on a pretested self prepared questionnaire. The questionnaire had questions pertaining to personal details, type of consanguineous marriages, history of trauma and examination of dental developmental anomalies.
UNASSIGNED: Multivariate logistic regression showed that non syndromic supernumerary teeth in fathers (p =.009); fusion in mothers (p = 0.002); fusion (p <0.001), nonsyndromic supernumerary teeth (p < 0.001), and microdontia (p = 0.002) in respondents were significantly associated with consanguinity.
UNASSIGNED: A significant association of developmental anomalies in parents with consanguineous marriages and their respondents was observed.
UNASSIGNED: Khan SY. An Exploratory Study of Consanguinity and Dental Developmental Anomalies. Int J Clin Pediatr Dent, 2018;11(6):513-518.

OBJECTIVE: The aim of this study was to evaluate the prevalence of dental anomalies (DAs) in Odisha population using panoramic radiographs.
METHODS: In this study, 1,080 panoramic radiographs were evaluated for DAs. Dental records were reviewed for diagnostic confirmation. Anomalies related to the shape, size, position of teeth, and number of roots (supernumerary roots) were evaluated.
RESULTS: The study results showed the prevalence of DAs to be 35.27%. The most prevalent was dilaceration, which was seen in 46.71% cases followed by peg laterals in 20.99%.
CONCLUSIONS: Dental anomalies were present in more than one-third of the study group, which was mostly related to shape of the teeth. Early diagnosis of these DAs helps in avoiding complications.
CONCLUSIONS: Identification of DAs requires proper examination and thereby subsequent correct diagnosis. These anomalies can pose complications in normal functioning of orofacial complex. The knowledge of the prevalence of such anomalies aids dental practitioners for a proper treatment plan.

OBJECTIVE: To identify genetic and environmental factors contributing to hypodontia and microdontia by using Korean twin family data.
METHODS: A total of 1267 individuals (525 men and 742 women; 180 monozygotic twins [MZ] and 43 dizygotic twins [DZ] from 282 families) underwent an oral examination as part of the Healthy Twin Study in Korea. Dental anomalies classified as hypodontia or microdontia were diagnosed using radiographs and clinical examinations. In order to estimate genetic contributions to dental anomalies, we estimated the pairwise concordance rate (PCR), recurrence risk ratio (RRR), and heritability (h2).
RESULTS: The prevalence of hypodontia and microdontia was 3.55% and 3.00%, respectively. MZ had the highest PCR and RRR (13.0-15.3). The PCR and RRR values for both anomalies were much higher for DZ (5.0-11.9) than for siblings (1.4-2.6), despite the fact that DZ pairs and sibling pairs share 50% genetic identity. Further genetic analysis revealed both an additive genetic effect (0.38 when hypodontia and microdontia were pooled) and a strong \"twin effect\" (0.52 when hypodontia and microdontia were pooled).
CONCLUSIONS: This twin-based study revealed that the formation of dental anomalies is affected by both genetic and environmental factors, and that the impact of these factors varies according to the specific dental anomaly.