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Abstract：
BACKGROUND: Mutations in one or multiple genes can lead to hypodontia and its characteristic features. Numerous studies have shown a strong genetic influence on the occurrence of hypodontia, and identified several genes, including AXIN2, EDA, FGF3, FGFR2, FGFR10, WNT10A, MSX1, and PAX9, that are directly associated with dental agenesis and carcinogenesis. The objective of this study was to investigate the occurrence and pattern of tooth agenesis, microdontia, and palatally displaced canine (PDC) in women diagnosed with papillary thyroid cancer (PTC), compared to a control group of women without any malignancy or thyroid disease.
METHODS: This case-control study was carried at the Department of Orthodontics, School of Dental Medicine University of Zagreb, and Department of Oncology and Nuclear Medicine Sestre Milosrdnice University Hospital Centre. The study involved a clinical examination and evaluation of dental status, panoramic X-ray analysis, and assessment of medical and family history of 116 female patients aged 20-40 with PTC, as well as 424 females in the control group who were of similar age.
RESULTS: The prevalence of hypodontia, microdontia, and PDC was statistically higher in women with PTC than in the control group. The prevalence rate of hypodontia was 11.3% in the experimental group and 3.5% in the control group. The experimental group showed a higher occurrence of missing upper lateral incisors, lower left central incisors, and all the third molars (except the upper left) compared to the control group. Women with PTC showed the prevalence of PDC significantly higher than the control group (3.5%, 0.7%, p = 0.002). The probability of hypodontia as a clinical finding increases 2.6 times, and microdontia occurs 7.7 times more frequently in women with PTC.
CONCLUSIONS: Our study suggests a possible link between odontogenesis and PTC. The absence of permanent teeth may increase the likelihood of PTC in women. Leveraging the age-7 orthopantomogram to identify women at high risk for PTC within a critical early detection window could significantly improve oral health outcomes and PTC prognosis through proactive interventions.
METHODS: This case-control study was carried at the Department of Orthodontics, School of Dental Medicine University of Zagreb, and Department of Oncology and Nuclear Medicine Sestre Milosrdnice University Hospital Centre. The study involved a clinical examination and evaluation of dental status, panoramic X-ray analysis, and assessment of medical and family history of 116 female patients aged 20-40 with PTC, as well as 424 females in the control group who were of similar age.
RESULTS: The prevalence of hypodontia, microdontia, and PDC was statistically higher in women with PTC than in the control group. The prevalence rate of hypodontia was 11.3% in the experimental group and 3.5% in the control group. The experimental group showed a higher occurrence of missing upper lateral incisors, lower left central incisors, and all the third molars (except the upper left) compared to the control group. Women with PTC showed the prevalence of PDC significantly higher than the control group (3.5%, 0.7%, p = 0.002). The probability of hypodontia as a clinical finding increases 2.6 times, and microdontia occurs 7.7 times more frequently in women with PTC.
CONCLUSIONS: Our study suggests a possible link between odontogenesis and PTC. The absence of permanent teeth may increase the likelihood of PTC in women. Leveraging the age-7 orthopantomogram to identify women at high risk for PTC within a critical early detection window could significantly improve oral health outcomes and PTC prognosis through proactive interventions.
摘要：
背景：一个或多个基因中的突变可导致低体及其特征性特征。大量研究表明，遗传对低体症的发生有很强的影响，并鉴定了几个基因，包括AXIN2，EDA，FGF3,FGFR2,FGFR10,WNT10A,MSX1和PAX9与牙体发育不全和癌变直接相关。这项研究的目的是调查牙齿发育不全的发生和模式，microdontia,诊断为甲状腺乳头状癌（PTC）的女性患者的腭移位犬（PDC），与没有任何恶性肿瘤或甲状腺疾病的对照组女性相比。
方法：本病例对照研究在口腔正畸科进行。萨格勒布大学牙科医学院，和肿瘤和核医学部门SestreMilosrdnice大学医院中心。该研究涉及临床检查和评估牙齿状况，全景X射线分析，对116例20-40岁女性PTC患者的病史和家族史进行评估，以及对照组中年龄相似的424名女性。
结果：低酮症的患病率，microdontia,女性PTC患者的PDC在统计学上高于对照组。实验组牙体功能低下的患病率为11.3%,对照组为3.5%。实验组上侧切牙缺失发生率较高,左下中央切牙,与对照组相比，所有第三磨牙（左上除外）。女性PTC患者PDC患病率明显高于对照组(3.5%,0.7%，p=0.002)。作为临床发现的牙髓不足的概率增加了2.6倍，在PTC女性中，microdontia的发生率是其7.7倍。
结论：我们的研究表明牙本质发育与PTC之间可能存在联系。没有恒牙可能会增加女性患PTC的可能性。在关键的早期检测窗口内，利用7岁正像图识别PTC高危女性，可以通过积极的干预措施显着改善口腔健康结果和PTC预后。
方法：本病例对照研究在口腔正畸科进行。萨格勒布大学牙科医学院，和肿瘤和核医学部门SestreMilosrdnice大学医院中心。该研究涉及临床检查和评估牙齿状况，全景X射线分析，对116例20-40岁女性PTC患者的病史和家族史进行评估，以及对照组中年龄相似的424名女性。
结果：低酮症的患病率，microdontia,女性PTC患者的PDC在统计学上高于对照组。实验组牙体功能低下的患病率为11.3%,对照组为3.5%。实验组上侧切牙缺失发生率较高,左下中央切牙,与对照组相比，所有第三磨牙（左上除外）。女性PTC患者PDC患病率明显高于对照组(3.5%,0.7%，p=0.002)。作为临床发现的牙髓不足的概率增加了2.6倍，在PTC女性中，microdontia的发生率是其7.7倍。
结论：我们的研究表明牙本质发育与PTC之间可能存在联系。没有恒牙可能会增加女性患PTC的可能性。在关键的早期检测窗口内，利用7岁正像图识别PTC高危女性，可以通过积极的干预措施显着改善口腔健康结果和PTC预后。
