Abstract：
To investigate the distribution of dental anomalies between non-syndromic orofacial cleft patients and their association with the cleft type and gender.
Retrospective cross-sectional study involving examination of intraoral dental records and radiographs.
300 non-syndromic orofacial cleft patients included (161 males and 139 females, mean age: 10.23 ± 2.3 years).
Variables analyzed: tooth agenesis, microdontia, and supernumerary teeth. Data analysis: Chi-square and Fisher\'s exact tests to investigate the correlation between dental anomalies, cleft type, and gender.
Agenesis occurred in 66% of the subjects, supernumerary teeth in 19.6%, and microdontia in 18.3%. In females with unilateral left cleft lip and palate (CLP), agenesis was significantly higher compared to males. Both genders presented significant agenesis of maxillary lateral incisors and right central incisor. Significant agenesis of central incisor, canine and second premolar on the upper left side and lower second premolars were observed only in males, with significant microdontia for maxillary lateral incisors and left central incisor. Significant agenesis of maxillary first premolars was seen only in females. Agenesis in maxillary quadrants was significant for patients with unilateral right and left CLP, and bilateral CLP. In mandibular quadrants, agenesis was substantially higher for patients with isolated CP.
Results suggest that tooth agenesis and microdontia might not be directly associated with the cleft area\'s anatomical irregularity but are affected by gender and other genetic factors that regulate the development of the anomaly and the orofacial clefting mutually.
Retrospective cross-sectional study involving examination of intraoral dental records and radiographs.
300 non-syndromic orofacial cleft patients included (161 males and 139 females, mean age: 10.23 ± 2.3 years).
Variables analyzed: tooth agenesis, microdontia, and supernumerary teeth. Data analysis: Chi-square and Fisher\'s exact tests to investigate the correlation between dental anomalies, cleft type, and gender.
Agenesis occurred in 66% of the subjects, supernumerary teeth in 19.6%, and microdontia in 18.3%. In females with unilateral left cleft lip and palate (CLP), agenesis was significantly higher compared to males. Both genders presented significant agenesis of maxillary lateral incisors and right central incisor. Significant agenesis of central incisor, canine and second premolar on the upper left side and lower second premolars were observed only in males, with significant microdontia for maxillary lateral incisors and left central incisor. Significant agenesis of maxillary first premolars was seen only in females. Agenesis in maxillary quadrants was significant for patients with unilateral right and left CLP, and bilateral CLP. In mandibular quadrants, agenesis was substantially higher for patients with isolated CP.
Results suggest that tooth agenesis and microdontia might not be directly associated with the cleft area\'s anatomical irregularity but are affected by gender and other genetic factors that regulate the development of the anomaly and the orofacial clefting mutually.
摘要：
目的探讨非综合征性口面部裂患者牙齿畸形的分布及其与裂类型和性别的关系。
涉及口腔内牙科记录和X光片检查的回顾性横断面研究。
300例非综合征性口面部裂患者（男性161例，女性139例，平均年龄：10.23±2.3岁）。
分析的变量：牙齿发育不全，microdontia,和多余的牙齿。数据分析：卡方和Fisher精确检验，以调查牙齿异常之间的相关性，裂隙类型,和性别。
发生在66%的受试者中，19.6%的多余牙齿，和microdontia占18.3%。在单侧左唇腭裂（CLP）的女性中，与男性相比，发育不全明显更高。两种性别均表现出上颌侧切牙和右中切牙的显着发育不良。中切牙显著发育不良，犬和第二前磨牙上左侧和下第二前磨牙只在男性中观察到，上颌侧切牙和左中切牙有明显的微小牙体。上颌第一前磨牙的发育不全仅在女性中可见。对于单侧左右CLP患者，上颌象限的发育不全具有重要意义，和双边CLP。在下颌象限中，孤立性CP患者的发育不全明显更高.
结果表明，牙齿发育不全和微小牙体可能与裂隙区域的解剖不规则性没有直接关系，但受到性别和其他遗传因素的影响，这些因素共同调节异常和口面裂隙的发展。
涉及口腔内牙科记录和X光片检查的回顾性横断面研究。
300例非综合征性口面部裂患者（男性161例，女性139例，平均年龄：10.23±2.3岁）。
分析的变量：牙齿发育不全，microdontia,和多余的牙齿。数据分析：卡方和Fisher精确检验，以调查牙齿异常之间的相关性，裂隙类型,和性别。
发生在66%的受试者中，19.6%的多余牙齿，和microdontia占18.3%。在单侧左唇腭裂（CLP）的女性中，与男性相比，发育不全明显更高。两种性别均表现出上颌侧切牙和右中切牙的显着发育不良。中切牙显著发育不良，犬和第二前磨牙上左侧和下第二前磨牙只在男性中观察到，上颌侧切牙和左中切牙有明显的微小牙体。上颌第一前磨牙的发育不全仅在女性中可见。对于单侧左右CLP患者，上颌象限的发育不全具有重要意义，和双边CLP。在下颌象限中，孤立性CP患者的发育不全明显更高.
结果表明，牙齿发育不全和微小牙体可能与裂隙区域的解剖不规则性没有直接关系，但受到性别和其他遗传因素的影响，这些因素共同调节异常和口面裂隙的发展。
