目的:微生物性角膜炎(MK),是全球视力丧失的常见原因,特别是在低收入和中等收入国家。本研究旨在调查乌干达MK的危险因素。方法:使用嵌套的案例控件,我们在2016年12月至2018年3月期间在乌干达南部的两个主要眼部病房招募了MK患者的健康社区对照.对照组分别进行年龄匹配,性别和村庄的比例为1:1。我们收集了人口统计信息,职业,HIV和糖尿病状态。在STATA14.1版中,使用多变量条件逻辑回归来生成MK危险因素的比值比,并使用似然比检验来评估关联的统计学意义。结果:纳入了215对病例对照。病例中HIV阳性患者为9%,对照组为1%,p=.0003。糖尿病患者为7%,对照组为1.4%,p=.012。病例和对照组的眼外伤为29%,而对照组为0%。在根据年龄调整的多变量模型中,性别和村庄,HIV(OR83.5,95CI2.01-3456,p=.020),糖尿病(OR9.38,95%CI1.48-59.3,p=0.017)和农业职业(OR2.60,95CI1.21-5.57,p=0.014)与MK相关。与较低的社会经济地位相比,中间状态与MK相关的可能性较小(OR0.29,95CI0.09-0.89,p<.0001)。结论:MK与HIV相关,糖尿病,贫穷,以农业为主要职业。需要更多的研究来探索这些因素如何诱发MK。
Purpose: Microbial keratitis (MK), is a frequent cause of sight loss worldwide, particularly in low and middle-income countries. This study aimed to investigate the risk factors of MK in Uganda.Methods: Using a nested
case control, we recruited healthy community controls for patients presenting with MK at the two main eye units in Southern Uganda between December 2016 and March 2018. Controls were individually matched for age, gender and village of the cases on a 1:1 ratio. We collected information on demographics, occupation, HIV and Diabetes Mellitus status. In STATA version 14.1, multivariable conditional logistic regression was used to generate odds ratios for risk factors of MK and a likelihood ratio test used to assess statistical significance of associations.Results: Two hundred and fifteen
case-control pairs were enrolled. The HIV positive patients among the cases was 9% versus 1% among the controls, p = .0003. Diabetes 7% among the cases versus 1.4% among the controls, p = .012. Eye trauma was 29% versus 0% among the cases and controls. In the multivariable model adjusted for age, sex and village, HIV (OR 83.5, 95%CI 2.01-3456, p = .020), Diabetes (OR 9.38, 95% CI 1.48-59.3, p = .017) and a farming occupation (OR 2.60, 95%CI 1.21-5.57, p = .014) were associated with MK. Compared to a low socio-economic status, a middle status was less likely to be associated with MK (OR 0.29, 95%CI 0.09-0.89, p < .0001).Conclusion: MK was associated with HIV, Diabetes, being poor and farming as the main occupation. More studies are needed to explore how these factors predispose to MK.