背景:血小板减少综合征(SFTS)是由SFTS病毒(SFTSV)引起的蜱传疾病,有可能成为大流行,目前是主要的公共卫生问题。
方法:我们介绍了一个来自重庆市区的74岁女性的案例,白细胞减少症,血小板减少症,器官功能,炎症,血液凝固,和免疫异常。通过分子检测和宏基因组下一代测序(mNGS)分析证实了SFTSV感染,由于患者的蜱叮咬史,表明SFTS的诊断。患者接受对症和支持治疗,包括抗生素,抗病毒治疗,和抗真菌治疗,终于在第18天出院了.
结论:这项研究强调了提高意识的必要性,早期诊断,并迅速治疗蜱传SFTS。它还提供了一个全面的了解疾病的特点,发病机制,检测方法,和可用的治疗方法。
BACKGROUND: Severe Fever with Thrombocytopenia Syndrome (SFTS) is a tick-borne disease caused by the SFTS virus (SFTSV) which has the potential to become a pandemic and is currently a major public health concern.
METHODS: We present the case of a 74-year-old female from an urban area of Chongqing, with leukocytopenia, thrombocytopenia, organ function, inflammatory, blood coagulation, and immune abnormalities. SFTSV infection was confirmed through molecular detection and metagenomic next-generation sequencing (mNGS) analysis, indicating a diagnosis of SFTS due to the patient\'s history of tick bites. The patient received symptomatic and supportive therapy, including antibiotics, antiviral treatment, and antifungal therapy, and finally discharged from the hospital on day 18.
CONCLUSIONS: This study highlights the need for increased awareness, early diagnosis, and prompt treatment for tick-borne SFTS. It also provides a comprehensive understanding of the disease\'s characteristics, pathogenesis, detection methods, and available treatments.