系统性红斑狼疮(SLE)是一种复杂的自身免疫性疾病,身体对自身抗原失去耐受性,特别是核抗原。T细胞和B细胞的异常反应导致自身抗体的产生和组织中免疫复合物的形成,触发补体激活,炎症,和不可逆的器官损伤。SLE可以影响身体的任何部位,导致不同的临床症状。SLE的一种罕见表现是狼疮肠系膜血管炎(LMV),表现出模糊的症状,异常的实验室发现,和特定的成像特征。LMV,虽然不常见,可以发展为严重的并发症,如肠穿孔,出血,甚至死亡率。这里,我们报告了一例累及多器官系统的LMV(包括皮肤粘膜,肌肉骨骼,浆膜腔,和血液系统),最初出现危及生命的顽固性胃肠道出血,并发严重的肺部感染.通过分享这个案例,我们的目标是增强临床医生对严重SLE病例的管理信心,并提高对疾病监测的认识.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease where the body loses tolerance to its own antigens, particularly nuclear antigens. Abnormal responses from T and B cells lead to the production of autoantibodies and the formation of immune complexes in tissues, triggering complement activation, inflammation, and irreversible organ damage. SLE can affect any part of the body, resulting in diverse clinical symptoms. One rare manifestation of SLE is lupus mesenteric vasculitis (LMV), which presents with vague symptoms, abnormal laboratory findings, and specific imaging features. LMV, although uncommon, can progress to severe complications such as bowel perforation, haemorrhage, and even mortality. Here, we report a
case of LMV with the involvement of multiple organ systems (including mucocutaneous, musculoskeletal, serosal cavities, and haematological systems), presenting initially with life-threatening intractable gastrointestinal bleeding, and complicated by severe pulmonary infection. By sharing this
case, we aim to enhance clinicians\' confidence in managing critical SLE cases and raise awareness about disease surveillance.