目的:生活指南的目标是随着新证据的出现,使指南中的建议保持最新。这篇综述旨在对医学领域生活指南的患病率和形式特征进行范围界定,并探讨格式之间的差异。
方法:通过PubMed在MEDLINE中选择性搜索生活指南,谷歌学者和六个相关的在线存储库指南(MAGICApp,AWMF,GIN,Nice,WHO-Iris,BIGG)进行了。联系了作者和编辑,以获得以前的非生命指南版本。随后根据如下所述的预定义的方法学标准分析生活指南(相互比较)。评估了生活和常规(非生活)版本之间的差异(内部比较)。
结果:确定并选择了83个生活指南进行进一步筛查,其中26人符合分析条件。61.5%是新出版物(从头指南),38.5%是现有指南的更新。有一些概念定义,例如,更新周期(AWMF,最长为12个月),但并非所有生活指南都遵循或引用现有概念。分析表明,符合(非生命)临床指南既定标准的生活指南涉及证据标准,广泛的共识过程(通常以德尔菲过程的形式),以及将利益相关者(患者/亲属)纳入发展过程,尽管更新频率很高。当将生活指南和常规指南与描述性方法进行比较时,发现更新频率有所变化(生活指南更频繁,最迟每年)和出版物格式(走向更多的数字化)和公众咨询(生活指南提供了更多的可能性),在共识过程的描述中没有观察到实质性的方法学差异,建议数量的变化,纳入患者代表。鉴于可比对的数量很少,结果反映了分析样品的趋势。
结论:生活指南的定义和发展各不相同。标准化(i。e.以清单的形式,程序模板)是评估生活过程质量所必需的。
OBJECTIVE: The goal of living
guidelines is keeping recommendations in
guidelines up-to-date as new evidence becomes available. This review aims at scoping the prevalence and formal characteristics of living guidelines in the field of medicine and explore differences between formats.
METHODS: A selective search of living
guidelines in
MEDLINE via PubMed, Google Scholar and six relevant online repositories for guidelines (MAGICApp, AWMF, GIN, NICE, WHO-Iris, BIGG) was conducted. Authors and editors were contacted to receive previous non-living
guideline versions. Living guidelines were subsequently analyzed according to pre-defined methodological criteria as described below (inter-comparison). Differences between living and their conventional (non-living) versions were assessed (intra-comparison).
RESULTS: 83 living guidelines were identified and selected for further screening, out of which 26 were eligible for analysis. 61.5% were new publications (de-novo guidelines) and 38.5% updates of pre-existing guidelines. There are some concepts defining, for example, the update cycle (AWMF, maximum of 12 months) but not all living guidelines follow or refer to existing concepts. The analysis shows that living guidelines in line with the established standards for (non-living) clinical
guidelines involve an evidence standard, an extensive
consensus process (often in the form of a Delphi process), and the inclusion of stakeholders (patients/relatives) in the development process, despite the high frequency of updates. When comparing living and conventional guidelines with the descriptive approach changes were found in update frequency (being more frequent with living guidelines, annually at the latest) and publication format (towards more digital) and public consultation (living guidelines offered more possibilities), no substantial methodological differences were observed in the description of
consensus processes, changes in number of recommendations, inclusion of patient representatives. Given the small number of comparable pairs, the results reflect a tendency in the analyzed sample.
CONCLUSIONS: The definition and development of living guidelines varied. Standardization (i. e. in the form of a checklist, procedure template) is needed to assess quality of the living process.