■扩大以前的调查,本研究旨在阐明脂质代谢紊乱在颅内动脉粥样硬化性狭窄(ICAS)发生发展过程中的作用,以及确定卒中风险.主要目的是探讨血脂参数与急性缺血性卒中(AIS)之间的联系,同时还检查了空腹血糖水平的潜在中介影响。
■回顾,我们收集了苏州大学附属第一医院有症状的ICAS患者的数据,包括他们的基线信息,如病史和入院血液生化指标。使用磁共振成像评估狭窄状况,计算机断层扫描血管造影,或者数字减影血管造影.通过多变量逻辑回归分析研究血脂参数与AIS风险之间的关联。
■共招募了1103例有症状的ICAS患者,其中441例(40.0%)在住院期间发生新的缺血事件.在调整混杂因素后,RCS曲线显示出血浆动脉粥样硬化指数(AIP)之间的剂量反应关系,总胆固醇(TC),低密度脂蛋白胆固醇(LDL-C),和AIS。进一步的多变量分析显示,这些参数与AIS之间存在显着关联。此外,中介分析表明,空腹血糖(FBG)在血脂参数(AIP,TC,和TG)和AIS。
■ICAS患者的血脂参数较高,特别是AIP,TC,TG,与AIS风险增加有关。此外,FBG可能介导ICAS患者的卒中风险,强调需要进一步探索潜在机制。
UNASSIGNED: Expanding on previous investigations, this study aims to elucidate the role of lipid metabolism disorders in the development of intracranial atherosclerotic stenosis (ICAS) and the determination of stroke risk. The primary objective is to explore the connections between lipid parameters and acute ischemic stroke (AIS), while also examining the potential mediating influence of fasting glucose levels.
UNASSIGNED: Retrospectively, we collected data from symptomatic ICAS patients at the First Affiliated Hospital of Soochow University, including their baseline information such as medical histories and admission blood biochemical parameters. Stenotic conditions were evaluated using magnetic resonance imaging, computed tomography angiography, or digital subtraction angiography. The associations between lipid parameters and AIS risks were investigated via multivariate logistic regression analysis.
UNASSIGNED: A total of 1103 patients with symptomatic ICAS were recruited, among whom 441 (40.0%) suffered new ischemic events during hospitalization. After adjusting for confounding factors, the RCS curves exhibited a dose-response relationship between the atherogenic index of plasma (AIP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and AIS. Further multivariate analysis revealed significant associations between these parameters and AIS. Furthermore,
mediation analysis indicated that fasting blood glucose (FBG) acted as a mediator in the association between lipid parameters (AIP, TC, and TG) and AIS.
UNASSIGNED: Higher lipid parameters in ICAS patients, particularly AIP, TC, and TG, were associated with an increased AIS risk. Additionally, FBG may mediate stroke risk in ICAS patients, highlighting the need for further exploration of underlying mechanisms.