■人格障碍通常与失眠和抑郁有关,但是对这些变量之间的相互关系知之甚少。因此,这项研究探讨了这些相互关系以及失眠在特定人格病理与抑郁严重程度之间的可能中介作用。
■有138名研究参与者,包括69名抑郁症患者和69名健康对照者。主要变量通过汉密尔顿抑郁量表-24(HAMD-24)测量,雅典睡眠失眠量表(AIS),和人格诊断问卷(PDQ-4+)。进行多元线性回归和中介分析。
■除了反社会人格得分,抑郁组的PDQ-4+评分和AIS评分均显著高于健康对照组(p<0.001).在总样本中,所有人格病理学评分(p<0.001),除了反社会人格得分,与AIS评分和HAMD-24评分呈显著正相关,AIS评分与HAMD-24评分呈正相关(r=0.620,p<0.001)。回归分析显示,边缘性人格,被动攻击性人格,失眠积极预测抑郁症的严重程度,在调整社会人口统计学协变量后,失眠部分介导了边缘性人格和被动攻击性人格与抑郁严重程度的关联。
■边缘人格,被动攻击性人格,失眠会增加抑郁症的严重程度,边缘性和被动攻击性人格对抑郁严重程度的影响可能部分由失眠介导。这是第一项在中国样本中报告这些发现的研究,它们可以帮助研究人员更好地理解从特定的人格病理到抑郁症的精神病理学的途径,这对于设计缓解抑郁严重程度的干预措施是有用的,因为应该考虑特定人格病理和失眠的影响。
UNASSIGNED: Personality disorders are frequently associated with insomnia and depression, but little is known about the inter-relationships among these variables. Therefore, this study examined these inter-relationships and the possible mediating effect of insomnia on the association between specific personality pathologies and depression severity.
UNASSIGNED: There were 138 study participants, including 69 individuals with depression and 69 healthy controls. The main variables were measured by the Hamilton Depression Rating Scale-24 (HAMD-24), Athens Sleep Insomnia Scale (AIS), and the Personality Diagnostic Questionnaire (PDQ-4+). Multivariate linear regression and
mediation analysis were conducted.
UNASSIGNED: With the exception of the antisocial personality score, all the PDQ-4+ scores and AIS scores were significantly higher in the depression group than in the healthy control group (p < 0.001). In the total sample, all personality pathology scores (p < 0.001), except the antisocial personality score, had significant positive correlations with the AIS scores and HAMD-24 scores, and the AIS scores and HAMD-24 scores were positively correlated (r = 0.620, p < 0.001). Regression analysis revealed that borderline personality, passive-aggressive personality, and insomnia positively predicted the severity of depression, after adjusting for sociodemographic covariates, and that insomnia partially mediated the associations of borderline personality and passive-aggressive personality with depression severity.
UNASSIGNED: Borderline personality, passive-aggressive personality, and insomnia tend to increase the severity of depression, and the effect of borderline and passive-aggressive personality on depression severity may be partially mediated by insomnia. This is the first study to report these findings in a Chinese sample, and they may help researchers to understand the pathways from specific personality pathologies to the psychopathology of depression better, which should be useful for designing interventions to relieve depression severity, as the impact of specific personality pathology and insomnia should be considered.