Maternal mortality

产妇死亡率
  • 文章类型: Journal Article
    这篇综述的主要目的是评估预防贫血的障碍,以及贫血妇女对其状况的态度和行为。因为铁对神经发育至关重要,缺铁性贫血(IDA)占怀孕母亲贫血的大多数。在印度和其他发展中国家,贫血是一个严重的健康问题。超过一半的孕妇患有贫血。搜索策略在PubMed中进行。没有使用MeSH术语搜索的文章很少。母亲贫血与其后代贫血之间的强相关性表明代际贫血具有持久的后果。出生时体重不足和营养不良的儿童患贫血的风险更高。临床医生通常评估贫血,本简要综述概述了确定贫血原因的标准。
    This review\'s main objective was to assess the obstacles to anemia prevention, as well as the attitudes and behaviors of anemic women toward their condition. Since iron is crucial for neurodevelopment, iron deficiency anemia (IDA) accounts for the majority of pregnant mothers having anemia. In India and other developing countries, anemia is a serious health problem. More than half of pregnant women have anemia. The search strategy was conducted in PubMed. Few of the articles were searched without using MeSH terms. Strong correlations between mothers\' anemia and that of their offspring point to intergenerational anemia with lasting consequences. Children who were underweight at birth and those who were malnourished had a higher risk of having anemia. Clinicians usually evaluate anemia, and the criteria for determining the cause of anemia are outlined in this brief review.
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  • 文章类型: Journal Article
    背景:死胎是一个主要的全球健康问题。一半的死胎发生在产时期间,主要在撒哈拉以南非洲和南亚的低收入和中等收入国家。到2030年实现每千名新生儿中不到12例的死胎率是每个新生儿行动计划和可持续发展目标的全球目标。有证据表明,提高产时护理质量可以帮助减少死胎和其他不良妊娠结局。这项研究将探讨产时护理点的质量改善(QI)包是否可以减少死胎和其他结果,例如孕产妇和新生儿死亡率。
    方法:我们将进行系统的文献综述和荟萃分析。将为PubMed数据库制定全面的搜索策略,WebofScience,ScienceDirect,ProQuest,科克伦与中国国家知识基础设施。我们将包括随机对照试验,非随机对照试验,对照临床试验,中断的时间序列,队列研究,病例对照和巢式病例对照研究,评估产时护理点QI干预对死胎和其他不良妊娠结局的影响。我们将搜索灰色文献,如未发表的研究报告,论文和未完成的试验。将包括英语和非英语语言文章,以避免语言偏见。我们还将评估报告质量和偏差风险。将对异质性进行敏感性测试。将使用随机效应模型计算效应大小的集合估计。将用定性叙事合成补充定量合成,如果认为有必要。我们将使用漏斗图和Egger的回归检验来探索出版偏差,如果需要。
    结论:我们将报告跨多个环境的不同产时QI干预措施在避免死产和其他不良结局如孕产妇死亡率和新生儿死亡率方面的综合有效性。
    BACKGROUND: Stillbirths are a major global health concern. Half of stillbirths occur during intrapartum period, mostly in low- and middle-income countries of sub-Saharan Africa and South Asia. Achieving a stillbirth rate of less than 12 per 1000 births by 2030 is the global target of Every Newborn Action Plan and Sustainable Development Goals. Evidence suggests that improving intrapartum quality of care can help reduce stillbirths and other adverse pregnancy outcomes. This study will explore whether quality improvement (QI) packages at intrapartum care points can reduce stillbirths and other outcomes such as maternal and neonatal mortality.
    METHODS: We will conduct a systematic literature review and meta-analysis. Comprehensive search strategy will be developed for databases PubMed, Web of Science, ScienceDirect, ProQuest, Cochrane and China National Knowledge Infrastructure. We will include randomized controlled trials, controlled non-randomized trials, controlled clinical trials, interrupted time series, cohort studies, case-control and nested case-control studies which assess the impact of QI interventions at intrapartum points of care on stillbirths and other adverse pregnancy outcomes. We will search grey literature such as unpublished research studies, dissertations and unfinished trials. English and non-English language articles will be included to avoid language bias. We will also evaluate reporting quality and risk of bias. Sensitivity tests will be carried out for heterogeneity. Pooled estimates of effect sizes will be computed with random-effects models. Supplementation of the quantitative synthesis with a qualitative narrative synthesis would be added, if deemed necessary. We will explore publication bias using funnel plot and Egger\'s regression test will be used for evaluation, if needed.
    CONCLUSIONS: We will report pooled effectiveness of different intrapartum QI interventions across multiple settings in averting stillbirths and other adverse outcomes such as maternal mortality and neonatal mortality.
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  • 文章类型: Systematic Review
    背景:印度尼西亚的孕产妇死亡率(MMR)是东南亚最高的国家之一。我们旨在描述过去几十年来印度尼西亚MMR的趋势和孕产妇死亡原因,区域和国家。
    方法:我们进行了系统综述,并使用PubMed进行了搜索,Embase,全球卫生,CINAHL,科克伦,Garuda门户,和谷歌学者从数据库成立到2023年4月。我们纳入了关于印度尼西亚孕产妇死亡发生率和/或原因的所有研究。MMR定义为每100,000例活产的产妇死亡人数。根据WHO国际疾病孕产妇死亡率分类(ICD-MM)对孕产妇死亡原因进行了评估和重新分类。
    结果:我们纳入了63项研究,这些研究报告了1970年至2022年印度尼西亚的MMR(54项研究)和/或孕产妇死亡原因(44项研究),共有254,796例孕产妇死亡。在1990年至2020年期间,全国MMR从450下降到249(45%)。全国各地的MMR存在很大差异,爪哇-巴厘岛最低,苏拉威西岛和印度尼西亚东部最高(超过全国MMR的两倍)。从1990年到2022年,由于出血和败血症导致的死亡比例下降,分别从48%到18%和15-5%,虽然高血压疾病和非产科原因导致的死亡比例增加,分别为8-19%和10-49%。
    结论:尽管印度尼西亚的孕产妇死亡率稳步下降,它仍然是东南亚最高的国家之一,国内差距巨大。高血压疾病和非传染性疾病在孕产妇死亡中所占比例越来越大,使减少孕产妇死亡的策略越来越具有挑战性。需要优先考虑全国孕产妇死亡监测和应对措施,以消除印度尼西亚可预防的孕产妇死亡。
    PROSPERO,CRD42022320213。
    BACKGROUND: The maternal mortality ratio (MMR) in Indonesia is among the highest in Southeast Asia. We aim to describe trends in the MMR and causes of maternal deaths in Indonesia over the past decades, regionally and nationally.
    METHODS: We performed a systematic review and conducted a search using PubMed, Embase, Global Health, CINAHL, Cochrane, Portal Garuda, and Google Scholar from the inception of the database to April 2023. We included all studies on the incidence and/or the causes of maternal deaths in Indonesia. The MMR was defined as the number of maternal deaths per 100,000 live births. Maternal death causes were assessed and reclassified according to the WHO International Classification of Disease Maternal Mortality (ICD-MM).
    RESULTS: We included 63 studies that reported the MMR (54 studies) and/or the causes of maternal deaths (44 studies) in Indonesia from 1970 to 2022, with a total of 254,796 maternal deaths. The national MMR declined from 450 to 249 (45%) between 1990 and 2020. Great differences in MMR exist across the country, with the lowest in Java-Bali and the highest (more than twice the national MMR) in Sulawesi and Eastern Indonesia. Between 1990 and 2022, the proportion of deaths due to hemorrhage and sepsis decreased, respectively from 48 to 18% and 15-5%, while the share of deaths due to hypertensive disorders and non-obstetric causes increased, respectively from 8 to 19% and 10-49%.
    CONCLUSIONS: Despite the steady decline of maternal deaths in Indonesia, it remains one of the highest in Southeast Asia, with enormous disparities within the country. Hypertensive disorders and non-communicable diseases make up a growing share of maternal deaths, making maternal death reduction strategies increasingly challenging. National Maternal Death Surveillance and Response needs to be prioritized to eliminate preventable maternal deaths in Indonesia.
    UNASSIGNED: PROSPERO, CRD42022320213.
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  • 文章类型: Journal Article
    背景:COVID-19大流行对全球和南非(SA)的卫生部门产生了深远的影响。
    目的:回顾COVID-19对孕产妇的影响,SA的围产期和生殖健康结果以及服务利用。
    方法:获得了三个常规的国家数据收集系统:地区卫生信息系统,全国孕产妇死亡机密调查委员会的拯救母亲报告和全国围产期发病率和死亡率委员会的拯救婴儿报告,使用围产期问题识别计划的数据。
    结果:孕产妇和死胎死亡率分别增加了35%和8%,分别,2020年和2021年,这与COVID-19浪潮相关。然而,2022年,费率恢复到COVID之前的水平。产前就诊和设施出生几乎没有变化,但是转向了更多的农村省份。2020年和2021年,口服和可注射避孕药的使用和终止妊娠服务显著减少,持续转向长效可逆避孕药。孕产妇死亡的增加主要是由于COVID-19呼吸系统并发症,但也增加了产科出血。出生体重在2000g至2499g之间的死胎显着增加(10%),主要归类为无法解释的死产或早产,但是没有观察到新生儿死亡的增加。行政可避免因素在2020-2022三年期增加了24%,但在大流行期间,患者/社区水平或医疗保健提供者相关的可避免因素没有增加.
    结论:由于病毒的直接影响和对卫生系统功能的间接影响,COVID-19在2020年和2021年导致孕产妇死亡和死胎率显着增加。Thecontinued,虽然修改了,妇女寻求健康的行为和迅速恢复到COVID-19之前的死亡率表明,妇女和卫生系统具有巨大的韧性。
    BACKGROUND: The COVID-19 pandemic had a profound effect on the health sector globally and in South Africa (SA).
    OBJECTIVE: To review the effects of COVID-19 on maternal, perinatal and reproductive health outcomes and service utilisation in SA.
    METHODS: Three routine national data collection systems were sourced: the District Health Information System, the Saving Mothers reports of the National Committee on Confidential Enquiry into Maternal Deaths and the Saving Babies reports from the National Perinatal Morbidity and Mortality Committee using data from the Perinatal Problem Identification Program.
    RESULTS: There were 35% and 8% increases in maternal and stillbirth mortality rates, respectively, in 2020 and 2021, which correlated with the COVID-19 waves. However, in 2022, rates returned to pre-COVID levels. Antenatal visits and facility births showed little change, but there was a shift to more rural provinces. The use of oral and injectable contraceptives and termination of pregnancy services decreased markedly in 2020 and 2021, with a sustained shift to long-acting reversible contraceptives. The increase in maternal deaths was predominantly due to COVID-19 respiratory complications, but also an increase in obstetric haemorrhage. Stillbirths increased significantly (10%) for birthweights between 2 000 g and 2 499 g, categorised mostly as unexplained stillbirths or preterm labour, but no increase in neonatal deaths was observed. Administrative avoidable factors increased by 24% in the 2020 - 2022 triennium, but there was no increase in patient/community level or healthcare provider-related avoidable factors during the pandemic years.
    CONCLUSIONS: COVID-19 caused a marked increase in maternal death and stillbirth rates in 2020 and 2021 due to both direct effects of the virus and indirect effects on functioning of the health system. The continued, although modified, health-seeking behaviour of women and the rapid return to pre-COVID-19 mortality rates demonstrates enormous resilience in women and the health system.
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  • 文章类型: Journal Article
    背景:孕产妇健康持续护理(COCM)是解决孕产妇和围产期死亡率的可预防原因的关键策略。尽管全球在减少孕产妇和婴儿死亡方面取得了显著进展,问题依然存在,特别是在低资源环境中。此外,各大洲之间和同一大陆国家内部在提供持续护理方面存在巨大差异。这项研究旨在评估非洲产妇护理连续体的总体完成率,并调查相关因素。
    方法:通过EMBASE访问了相关文章,CINAHL,科克伦图书馆,PubMed,Hinari,和谷歌学者数据库。漏斗图和Egger检验用于评估发表偏倚,而I平方检验用于评估研究异质性。纳入标准仅限于仅在非洲进行的观察性研究。使用JBI检查表评估这些研究的质量。使用MicrosoftExcel从所包括的研究中提取数据,然后使用Stata16软件进行分析。
    结果:共有23项研究涉及74,880名母亲,符合纳入标准。成功完成COCM的女性总体患病率为20.9%[95%CI:16.9-25.0]。我们的分析揭示了与这一结果相关的几个因素,包括城市居住权[OR:2.3;95%CI:1.6-3.2],最高财富指数水平[OR:2.1;95%CI:1.4-3.0],初产状态[OR:1.3;95%CI:2.2-5.1],计划妊娠[OR:3.0;95%CI:2.3-3.7],和暴露于大众媒体[OR:2.7;95%CI:1.9-3.8]。
    结论:研究显示,只有20.9%的女性完全完成了COCM。它还确定了与完成COCM相关的几个因素,例如居住在城市地区,拥有更高的财富指数,作为第一次做母亲,经历一次计划中的怀孕,并有机会接触大众媒体。根据研究结果,建议在农村地区实施有针对性的干预措施,向财富指数水平较低的妇女提供财政援助,通过大众媒体开展教育运动,促进早期产前保健,加强计划生育服务。
    背景:PROSPERO国际系统评价前瞻性注册(ID:CRD42020205736)。
    BACKGROUND: The continuum of care for maternal health (COCM) is a critical strategy for addressing preventable causes of maternal and perinatal mortality. Despite notable progress in reducing maternal and infant deaths globally, the problem persists, particularly in low-resource settings. Additionally, significant disparities in the provision of continuous care exist both between continents and within countries on the same continent. This study aimed to assess the pooled prevalence of completion across the maternity care continuum in Africa and investigate the associated factors.
    METHODS: Relevant articles were accessed through the EMBASE, CINAHL, Cochrane Library, PubMed, HINARI, and Google Scholar databases. Funnel plots and Egger\'s test were employed to assess publication bias, while the I-squared test was used to evaluate study heterogeneity. The inclusion criteria were limited to observational studies conducted exclusively in Africa. The quality of these studies was assessed using the JBI checklist. Data extraction from the included studies was performed using Microsoft Excel and then analysed using Stata 16 software.
    RESULTS: A total of 23 studies involving 74,880 mothers met the inclusion criteria. The overall prevalence of women who successfully completed the COCM was 20.9% [95% CI: 16.9-25.0]. Our analysis revealed several factors associated with this outcome, including urban residency [OR: 2.3; 95% CI: 1.6-3.2], the highest wealth index level [OR: 2.1; 95% CI: 1.4-3.0], primiparous status [OR: 1.3; 95% CI: 2.2-5.1], planned pregnancy [OR: 3.0; 95% CI: 2.3-3.7], and exposure to mass media [OR: 2.7; 95% CI: 1.9-3.8].
    CONCLUSIONS: The study revealed that only 20.9% of women fully completed the COCM. It also identified several factors associated with completion of the COCM, such as residing in urban areas, possessing a higher wealth index, being a first-time mother, experiencing a planned pregnancy, and having access to mass media. Based on the study\'s findings, it is recommended that targeted interventions be implemented in rural areas, financial assistance be provided to women with lower wealth index levels, educational campaigns be conducted through mass media, early antenatal care be promoted, and family planning services be strengthened.
    BACKGROUND: PROSPERO International Prospective Register of Systematic Reviews (ID: CRD42020205736).
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  • 文章类型: Journal Article
    在加拿大健康信息研究所的医院出院摘要数据库中,开发了数据库尸检方法来确定产妇死亡的可能原因,但该方法尚未得到验证。使用魁北克住院数据库中的直接死因信息作为黄金标准,本研究评估了妊娠相关死亡数据库尸检方法的有效性和可靠性.该方法对确定这些死亡的最常见原因具有很高的敏感性和特异性,以及高级观察员协议。我们得出的结论是,数据库尸检方法总体上是有效和可靠的。
    The database autopsy method was developed to determine probable causes of maternal deaths in the Canadian Institute for Health Information\'s hospital discharge abstract database; however, the method has yet to be validated. Using immediate cause of death information from Québec\'s hospitalization database as the gold standard, this study assessed the validity and reliability of the database autopsy method for pregnancy-associated deaths. The method had high sensitivity and specificity for identifying the most common causes of these deaths, as well as high interobserver agreement. We conclude that the database autopsy method is valid and reliable overall.
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  • 文章类型: Journal Article
    为了克服纸张的缺点,加强分娩和分娩期间的护理,改善记录保存,帮助决策,一些国家已经专注于采用低成本的数字应用。此范围审查重点介绍了数字模式在产科护理中的可用性和现状。我们进行了彻底的搜索,涉及数据库ScienceDirect,PubMed,和谷歌学者通过使用关键词“partograph”,从开始到2023年9月进行相关研究\"电子\",和“产科”以及布尔运算符“AND”和“OR”。根据选择标准,该综述包括25项研究,这些研究探索了电子分娩图(e-partographs)在产科护理中的应用。大多数研究检查了效率,并报告了与纸质句图相比的电子句图的有效性。e-partograph还显示出明显的好处,因为医疗保健提供者填写了数据,并放置了一个提醒机制,这可能有助于确定分娩过程是否正常或需要更多护理。此外,对于产科护理人员来说,电子产图易于采用和使用,并且有可能节省时间.总而言之,数字Partograph产生优于纸质Partograph的结果。使用电子产图仪可以使分娩保持在正轨上,同时降低剖宫产和长期分娩的需求。e-partograph为其用户提供了基本的好处,并且还提供了具有听觉和视觉提示的警告系统,可用于检测交付过程中的困难。
    To overcome shortcomings of the paper partograph, enhance care during labor and delivery, improve record keeping, and help decision-making, several countries have focused on adopting low-cost digital applications. This scoping review highlights the usability and current status of the digital partogram in obstetric care. We conducted a thorough search involving the databases ScienceDirect, PubMed, and Google Scholar for relevant studies from inception till September 2023 by using the keywords \"partograph\", \"electronic\", and \"obstetric\" as well as the Boolean operators \"AND\" and \"OR\". Based on the selection criteria, 25 studies exploring the application of electronic partographs (e-partographs) in obstetric care were included in the review. The majority of the studies examined the efficiency and reported the effectiveness of e-partographs in comparison to paper partographs. The e-partograph has also demonstrated a clear benefit in that the healthcare providers filled out the data, and a reminder mechanism was placed, which might help determine whether the labor process was normal or needed more care. Moreover, an e-partograph was simple to adopt and use for obstetric caregivers and had the potential to save time. To sum up, digital partograph produces superior results to paper partograph. The use of an e-partograph can keep deliveries on track while lowering the need for cesarean sections and prolonged labor. The e-partograph provides essential benefits to its users and also provides a warning system with audible and visual cues that might be utilized to detect difficulties during delivery.
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  • 文章类型: Journal Article
    受人道主义危机影响的全球人口每年都在不断打破纪录,使紧张和破碎的卫生系统依赖于60多个国家的人道主义援助。然而,在受危机影响的情况下,对孕产妇和围产期死亡监测和响应(MPDSR)的实施知之甚少。此范围审查旨在综合有关在人道主义环境中实施MPDSR和相关死亡审查干预措施的证据。
    我们搜索了2016-22年出版的英文和法文的同行评审和灰色文献,这些文献报道了人道主义环境下的MPDSR和相关死亡审查干预措施。我们筛选并审查了1405条记录,其中我们确定了25篇同行评审的文章和11篇报告.然后,我们使用内容和主题分析来了解采用情况,适当性,保真度,穿透力,以及这些干预措施的可持续性。
    在36条记录中,33个独特的方案报告了27个国家在人道主义背景下的37项干预措施,占2023年联合国人道主义呼吁的国家的69%。大多数已确定的方案侧重于孕产妇死亡干预措施;处于试点或早期中期实施阶段(1-5年);在卫生系统中的整合有限。虽然我们确定了MPDSR和相关死亡评估干预措施的实质性文件,与收养有关的证据仍然存在巨大差距,保真度,穿透力,以及这些干预措施的可持续性。在人道主义背景下,实施受到严重的资源限制的影响,可变领导力,无处不在的指责文化,和社区内的不信任。
    紧急MPDSR实施动态显示了人道主义行为者之间复杂的相互作用,社区,和卫生系统,值得深入研究。未来的混合方法研究评估人道主义背景下已确定的MPDSR计划的范围将极大地增强证据基础。投资于比较卫生系统研究,以了解如何最好地将MPDSR和相关的死亡审查干预措施适应人道主义背景是至关重要的下一步。
    UNASSIGNED: The global population impacted by humanitarian crises continues to break records each year, leaving strained and fractured health systems reliant upon humanitarian assistance in more than 60 countries. Yet little is known about implementation of maternal and perinatal death surveillance and response (MPDSR) within crisis-affected contexts. This scoping review aimed to synthesise evidence on the implementation of MPDSR and related death review interventions in humanitarian settings.
    UNASSIGNED: We searched for peer-reviewed and grey literature in English and French published in 2016-22 that reported on MPDSR and related death review interventions within humanitarian settings. We screened and reviewed 1405 records, among which we identified 25 peer-reviewed articles and 11 reports. We then used content and thematic analysis to understand the adoption, appropriateness, fidelity, penetration, and sustainability of these interventions.
    UNASSIGNED: Across the 36 records, 33 unique programmes reported on 37 interventions within humanitarian contexts in 27 countries, representing 69% of the countries with a 2023 United Nations humanitarian appeal. Most identified programmes focussed on maternal death interventions; were in the pilot or early-mid implementation phases (1-5 years); and had limited integration within health systems. While we identified substantive documentation of MPDSR and related death review interventions, extensive gaps in evidence remain pertaining to the adoption, fidelity, penetration, and sustainability of these interventions. Across humanitarian contexts, implementation was influenced by severe resource limitations, variable leadership, pervasive blame culture, and mistrust within communities.
    UNASSIGNED: Emergent MPDSR implementation dynamics show a complex interplay between humanitarian actors, communities, and health systems, worthy of in-depth investigation. Future mixed methods research evaluating the gamut of identified MPDSR programmes in humanitarian contexts will greatly bolster the evidence base. Investment in comparative health systems research to understand how best to adapt MPDSR and related death review interventions to humanitarian contexts is a crucial next step.
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  • 文章类型: Journal Article
    本系统评价旨在探讨妊娠期骨盆环骨折(PRF)的治疗和结局,强调孕产妇和胎儿死亡率,损伤机制,和治疗方式。
    遵循系统评价和荟萃分析指南的首选报告项目,我们对2000年至2023年的数据库进行了全面检索,确定了33项相关研究.数据提取包括人口统计,骨折类型,治疗方法,和结果。使用JBI标准评估偏倚风险。
    产妇死亡率为9.1%,胎儿死亡率为42.4%。影响死亡率的产妇因素包括头部创伤和血流动力学不稳定。胎儿死亡率与机动车事故和孕产妇生命体征等机制相关。采用手术和保守治疗,大多数骨盆手术在分娩前进行。外固定器在骨折稳定方面被证明是有效的。
    妊娠期间的骨盆环骨折对母体和胎儿健康构成重大风险。孕产妇生命体征的早期稳定和警惕监测至关重要。阴道出血/出院是关键的胎儿风险指标。手术和保守治疗之间的选择对预后的影响最小。多学科协作和量身定制的干预措施对于管理这些复杂案件至关重要。
    UNASSIGNED: This systematic review aims to investigate the management and outcomes of pelvic ring fractures (PRFs) during pregnancy, emphasizing maternal and fetal mortality rates, mechanisms of injury, and treatment modalities.
    UNASSIGNED: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a comprehensive search of databases from 2000 to 2023, identifying 33 relevant studies. Data extraction included demographics, fracture types, treatment methods, and outcomes. Risk of bias was assessed using the JBI criteria.
    UNASSIGNED: Maternal mortality stood at 9.1%, with fetal mortality at 42.4%. Maternal factors impacting mortality included head trauma and hemodynamic instability. Fetal mortality correlated with mechanisms like motor vehicle accidents and maternal vital signs. Surgical and conservative treatments were applied, with a majority of pelvic surgeries performed before delivery. External fixators proved effective in fracture stabilization.
    UNASSIGNED: Pelvic ring fractures during pregnancy present significant risks to maternal and fetal health. Early stabilization and vigilant monitoring of maternal vital signs are crucial. Vaginal bleeding/discharge serves as a critical fetal risk indicator. The choice between surgical and conservative treatment minimally influenced outcomes. Multidisciplinary collaboration and tailored interventions are essential in managing these complex cases.
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  • 文章类型: Journal Article
    目的:在加拿大验尸官和医学检查官数据库(CCMED)中确定和审查与自杀和药物过量导致的孕产妇死亡相关的因素,从2017年到2019年。
    方法:我们通过检索10至60岁女性死亡的CCMED叙述的妊娠相关术语,确定了安大略省和不列颠哥伦比亚省潜在的孕产妇死亡。然后一式四份对确定的叙述进行定性审查,以确定它们是否是因自杀或药物过量而导致的孕产妇死亡,并提取有关母亲特征的信息,死亡的方式,以及与每次死亡相关的因素。
    结果:在这项研究中确定的90例死亡中,15(16.7%)是由于自杀,20(22.2%)是由于药物过量。这些死亡发生在不同年龄和整个妊娠至产后期间的妇女身上。在自杀事件中,十人被绞死,在与用药过量相关的死亡中,15检测到芬太尼。值得注意的是,35例自杀或药物过量死亡中有13例(37.1%)发生在怀孕后42天之后,19例(54.3%)流产或人工流产,23例(65.7%)有精神病史。15例自杀中的4例(26.7%)记录了物质使用障碍,20例过量相关死亡中的18例(90.0%)。
    结论:在加拿大,自杀和药物过量对孕产妇死亡的影响可能比以前意识到的更大。需要制定计划来识别有这些结果风险的妇女,并在怀孕期间和常规产后期间进行干预。
    OBJECTIVE: To identify and review factors associated with maternal deaths by suicide and drug overdose in the Canadian Coroner and Medical Examiners Database, from 2017 to 2019.
    METHODS: We identified potential maternal deaths in Ontario and British Columbia by searching the Canadian Coroner and Medical Examiners Database narratives of deaths to females 10 to 60 years old for pregnancy-related terms. Identified narratives were then qualitatively reviewed in quadruplicate to determine if they were maternal deaths by suicide or drug overdose, and to extract information on maternal characteristics, the manner of death, and factors associated with each death.
    RESULTS: Of the 90 deaths identified in this study, 15 (16.7%) were due to suicide and 20 (22.2%) were due to a drug overdose. These deaths occurred in women of varying ages and across the pregnancy-postpartum period. Among the suicides, 10 were by hanging, and among the overdose-related deaths, 15 had fentanyl detected. Notably, 13 (37.1%) of the 35 deaths to suicide or drug overdose occurred beyond 42 days after pregnancy, 19 (54.3%) followed a miscarriage or induced abortion, and in 23 (65.7%) there was an established history of mental health illness. Substance use disorders were documented in 4 of the 15 suicides (26.7%), and 18 of the 20 overdose-related deaths (90.0%).
    CONCLUSIONS: Suicide and drug overdose may contribute more to maternal deaths in Canada than previously realized. Programs are needed to identify women at risk of these outcomes and to intervene during pregnancy and beyond the conventional postpartum period.
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