背景口腔粘膜下纤维化(OSMF)是一种慢性,进步,和潜在的恶性口腔疾病,导致口腔疤痕,咽部,和上食管。这在东南亚最常见,但在世界其他地方也有发现。口腔潜在恶性疾病(OPMD)是一组口腔病变,其发展为口腔癌的风险增加。该研究旨在评估与其他OPMD相关的OSMF的患病率。一个患者体内存在多个OPMD是一个重要的发现,因为它与发展为恶性肿瘤的风险升高有关。恶性转化的风险随着患者中存在的OPMD数量的增加而增加;具有两个OPMD的患者发生恶性肿瘤的风险是具有单个OPMD的患者的三到四倍。具有三个或更多个OPMD的患者具有7-10倍的风险,并且恶性转化的风险取决于OPMD的类型。材料和方法该研究在口腔医学和放射科进行,Saveetha牙科学院和医院,钦奈,印度,调查OSMF与其他OPMD的患病率。研究小组在2018年1月至2023年3月期间从电子数据库中检索了630例OSMF患者的病例记录。研究中的所有患者都患有OSMF,以及其他OPMD,如白斑,念珠菌病,光化性唇炎,先天性角化障碍,红斑,扁平苔藓,sideropenic吞咽困难(Plummer-Vinson综合征),盘状红斑狼疮.临床和组织病理学检查均证实了这些诊断。排除没有共存OSMF的口腔粘膜病变。这项研究是根据年龄组进行的,习惯,习惯的类型,相关的共存病变,和系统条件。结果患者均经临床检查和诊断。在630个案例中,10%有OSMF和OPMD。与OSMF相关的最常见的OPMDs是白斑(86%),其次是念珠菌病(12%)和白斑和念珠菌病(2%)。基于性别,OSMF在男性中的发病率高于女性,分别为67%和33%,分别。结论OSMF更容易发展为恶性肿瘤;印度槟榔产品的广泛使用导致OSMF发病率上升。积累流行病学数据有助于确定高危人群的防控措施。早期的口腔癌诊断和治疗可以增加有利结果的可能性。
Background Oral submucous fibrosis (OSMF) is a chronic, progressive, and potentially malignant oral disorder that causes scarring of the oral cavity, pharynx, and upper oesophagus. It is most common in Southeast Asia, but it is also found in other parts of the world. Oral potentially malignant disorders (OPMDs) are a group of oral lesions that have an increased risk of developing into oral cancer. The
study aimed to evaluate the prevalence of OSMF associated with other OPMDs. The presence of multiple OPMDs existing in one patient is a significant finding, as it is associated with an elevated risk of developing malignancy. The risk of malignant transformation increases with the number of OPMDs present in a patient; patients with two OPMDs have a three to four times higher risk of developing malignancy than those with a single OPMD. Patients with three or more OPMDs have a 7-10 times higher risk and the risk of malignant transformation depends on the type of OPMD. Materials and methods The study was conducted in the Department of Oral Medicine and Radiology, Saveetha Dental College and Hospitals, Chennai, India, to investigate the prevalence of OSMF with other OPMDs. The
study team retrieved 630 case records of patients with OSMF from the electronic database between January 2018 and March 2023. All of the patients in the
study had OSMF, as well as other OPMDs such as
leukoplakia, candidiasis, actinic cheilitis, dyskeratosis congenita, erythroplakia, lichen planus, sideropenic dysphagia (Plummer-Vinson syndrome), and discoid lupus erythematosus. Both clinical and histopathological examinations confirmed these diagnoses. Oral mucosal lesions without coexisting OSMF were excluded. The study was done on the basis of age group, habits, type of habits, associated coexisting lesions, and systemic condition. Results The patients were clinically examined and diagnosed. Of the 630 cases, 10% had OSMF with OPMDs. The most common OPMDs associated with OSMF were
leukoplakia (86%), followed by candidiasis (12%) and both
leukoplakia and candidiasis (2%). Based on gender, the incidence of OSMF was higher in males compared to females with 67% and 33%, respectively. Conclusion OSMF is more likely to develop into malignancy; the widespread use of areca nut products in India has contributed to the rising incidence of OSMF. Accumulating epidemiological data can help to identify high-risk populations for prevention and control measures. Earlier oral cancer diagnosis and treatment can increase the likelihood of a favourable outcome.