目的:关于脂肪细胞释放的细胞因子,特别是脂联素,瘦素,和调节骨骼重塑的IL6。此外,IL6从肌肉收缩中释放出来,这可能在骨骼重塑中起着独特的作用。因此,这项研究调查了在40分钟高强度间歇训练(40分钟HIIT)期间和16周HIIT(16周HIIT)后的肌肉收缩是否改变了超重女性中这些细胞因子的释放和骨重建.
方法:总共,22超重,绝经前妇女被随机分为运动组或对照组.运动参与者每周三次以其心率储备(HRR)的80-90%参加40分钟的HIIT会议,持续16周,而对照参与者执行他们的日常活动。在禁食过夜后抽血,并在完成40分钟的HIIT会议后立即抽血,以研究脂联素的相关性。瘦素,IL6,CTX,和P1NP通过40分钟HIIT会话的急性效应。在16周干预计划后重复此过程,以观察HIIT对细胞因子连锁的训练作用。胫骨远端骨密度(BMD)水平,股骨,在16周的介入治疗前后,使用双能X射线吸收法确定腰椎和腰椎。
结果:在完成40分钟HIIT会议的第一个和最后一个回合后,P1NP水平增加了8.29-20.52%(95%CI)和2.91-15.54%,分别。此外,IL6增加了13.39-28.03%(95%CI),而血清CTX和脂联素与40分钟HIIT疗程的急性作用没有改变。P1NP和脂联素的增加之间存在关联(r=0.682,p=0.015);然而,在完成40分钟HIIT会话后,P1NP的增加主要与IL6的增加相关(r=0.572,p=0.054).在16周的HIIT计划之后,运动参与者的静息脂联素水平升高;然而,这与骨生物标志物和BMD无关.锻炼参与者的BMD得以维持;然而,16周后,对照组的胫骨BMD随着静息CTX水平的升高而降低.
结论:40分钟HIIT期间的肌肉收缩升高了IL6水平,这可能随后增强了骨骼形成。此外,脂联素和P1NP的急性变化之间的关联提示成骨细胞中脂联素受体敏感性增加的可能性.
OBJECTIVE: There is some controversy regarding cytokines released from adipocytes, particularly adiponectin,
leptin, and IL6 that regulate bone remodeling. In addition, IL6 is released from muscle contraction, which might have a distinct role in bone remodeling. Hence, this
study investigated whether muscle contraction during a session of 40 min of high intensity interval training (40-min HIIT) and after 16 weeks of HIIT (16-wk HIIT) altered the release of those cytokines and bone remodeling in overweight women.
METHODS: In total, 22 overweight, premenopausal women were randomly assigned to either the exercise or the control group. The exercise participants engaged in the 40-min HIIT session at 80-90 % of their heart rate reserve (HRR) three times weekly for 16 weeks, while the control participants performed their routine daily activities. Blood was drawn after overnight fasting and immediately after completing the 40-min HIIT sessions to investigate the association of adiponectin,
leptin, IL6, CTX, and P1NP through the acute effect of the 40-min HIIT sessions. This process was repeated after the 16-wk intervention program to observe the training effect of HIIT on cytokines linkage. The bone mineral density (BMD) levels of the distal tibia, femur, and lumbar spine were determined prior to and after the 16-wk intervention using dual-energy X-ray absorptiometry.
RESULTS: The P1NP level increased by 8.29-20.52 % (95 % CI) and by 2.91-15.54 % after completing the first and last bouts of the 40-min HIIT sessions, respectively. In addition, IL6 increased by 13.39-28.03 % (95 % CI), while serum CTX and adiponectin were unaltered from the acute effect of the 40-min HIIT sessions. There was an association between the increases in P1NP and adiponectin (r = 0.682, p = 0.015); however, the increase in P1NP was mostly associated with the increase in IL6 (r = 0.572, p = 0.054) after completing a 40-min HIIT session. After the 16-wk HIIT program, the resting adiponectin level of the exercise participants increased; however, this was associated with neither bone biomarkers nor BMD. The BMDs of the exercise participants were maintained; however, the tibial BMD of the control participants decreased with an increase in the resting CTX level after 16 weeks.
CONCLUSIONS: Muscle contraction during the 40-min HIIT session elevated the IL6 level, which might have subsequently enhanced bone formation. Furthermore, the association between acute changes in adiponectin and P1NP suggested the possibility of an increase in the sensitivity of the adiponectin receptor in osteoblasts.