■间歇性禁食(IF)和运动训练(Exe)已在多项研究中进行了评估,以改善与体重减轻有关的心脏代谢生物标志物。然而,需要进一步研究以了解对瘦素和脂联素浓度的潜在影响。如果方案已被证明在改善脂肪因子方面是有效的,但需要进一步的研究来确定IF方案联合Exe是否优于单独使用Exe.
■这项研究的目的是确定在有和没有肥胖的成年人中,结合IF加Exe的干预措施是否比Exe更有效地改善血清瘦素和脂联素。
■通过搜索PubMed,Scopus,和截至2023年8月的WebofScience数据库,用于确定IF加Exe与单独使用EXE(控制体重),血清瘦素,和血清脂联素。分析了IF加EXE与EXE单独计算加权平均差(WMD)和标准化平均差(SMD)。
■当前的荟萃分析包括6项研究,共153名参与者,干预持续时间从3天到52周不等。IF加Exe引起瘦素水平明显更大的下降[SMD=-0.47,p=0.03],伴随着体重减轻[WMD=-1.25公斤,p=0.05],与仅运动干预相比,但是脂联素在两者之间没有差异[SMD=0.02,p=0.9].
■IF与Exe联合使用可显着降低瘦素,但没有改变脂联素水平,与仅锻炼相比。也许这些瘦素水平的降低可能与体重减轻有关;然而,由于纳入的研究数量少,减肥结果的异质性高,这个结果是不确定的。
■https://www.crd.约克。AC.英国/普华永道/,标识符CRD42023460735。
UNASSIGNED: Intermittent fasting (IF) and exercise training (Exe) have been evaluated in several studies for improving cardiometabolic biomarkers related to weight loss. However, further investigation is required to understand the potential effects on
leptin and adiponectin concentrations. IF protocols have been shown to be efficient in improving adipokines, but further research is required to determine whether or not IF regimens combined with Exe are superior to Exe alone.
UNASSIGNED: The aim of this study was to determine whether or not interventions combining IF plus Exe are more effective than Exe only for improving serum leptin and adiponectin in adults with and without obesity.
UNASSIGNED: A systematic review and meta-analysis was performed by searching PubMed, Scopus, and Web of Science databases up to August 2023 for randomized clinical trials that determined the effects of IF plus Exe vs. Exe alone (control) on body weight, serum
leptin, and serum adiponectin. Analyses were conducted for IF plus Exe vs. Exe alone to calculate weighted mean differences (WMD) and standardized mean differences (SMD).
UNASSIGNED: The current meta-analysis included 6 studies with a total sample of 153 participants, with intervention durations ranging from three days to 52 weeks. IF plus Exe elicited significantly larger decreases in
leptin levels [SMD = -0.47, p = 0.03], which were accompanied by weight loss [WMD = -1.25 kg, p = 0.05], as compared with exercise-only interventions, but adiponectin did not differ between the two [SMD = 0.02, p = 0.9].
UNASSIGNED: IF combined with Exe reduced
leptin significantly, but did not change adiponectin levels, when compared to exercise only. Perhaps these reductions in
leptin levels may have been associated with weight loss; however, due to the small number of included studies and the high heterogeneity in the weight loss outcomes, this result is uncertain.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier CRD42023460735.