目的:结肠镜检查被认为是诊断幼年性息肉的最可靠方法。然而,结肠镜筛查是一种侵入性且昂贵的程序。粪便钙卫蛋白(FCP),肠道炎症的标志,已被证明在息肉患者中升高。因此,本研究旨在评估FCP作为诊断幼年性息肉的筛选生物标志物.
方法:这个横截面,观察性研究是在小儿胃肠病学和营养科进行的,BangabandhuSheikhMujib医科大学,达卡,孟加拉国。对于患有息肉的儿童,进行结肠镜息肉切除术和组织病理学检查。分析所有患者息肉切除术前和术后4周的FCP水平。信息记录在数据表中,并使用基于计算机的程序SPSS进行分析。
结果:儿童的年龄在2.5至12岁之间。在直肠乙状结肠区域发现了大约93%的息肉。患有幼年性息肉的儿童在息肉切除术前FCP水平升高,随后在息肉切除术后恢复正常。息肉切除术前后的平均FCP水平为277±247µg/g(范围,80-1,000µg/g)和48.57±38.23µg/g(范围,29-140µg/g)(p<0.001),分别。多发性息肉患者的FCP水平明显高于单发息肉患者。此外,单发和多发息肉患者的平均FCP水平分别为207.6±172.4µg/g和515.4±320.5µg/g(p<0.001),分别。
结论:发现结肠幼年性息肉与FCP水平升高相关,FCP水平在息肉切除术后恢复正常。因此,FCP可能被推荐作为结肠幼年性息肉诊断的非侵入性筛查生物标志物。
OBJECTIVE: Colonoscopy is considered the most reliable method for the diagnosis of juvenile polyps. However, colonoscopic screening is an invasive and expensive procedure. Fecal calprotectin (FCP), a marker of intestinal inflammation, has been shown to be elevated in patients with polyps. Therefore, this study aimed to evaluate FCP as a screening biomarker for the diagnosis of juvenile polyps.
METHODS: This cross-sectional, observational study was conducted at the Pediatric Gastroenterology and Nutrition Department, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. For children with polyps, colonoscopic polypectomy and histopathology were performed. FCP levels were analyzed before and 4 weeks after polypectomy in all patients. Information was recorded in a datasheet and analyzed using the computer-based program SPSS.
RESULTS: The age of the children was between 2.5 and 12 years. Approximately 93% of the polyps were found in the rectosigmoid region. Children with juvenile polyps had elevated levels of FCP before polypectomy that subsequently normalized after polypectomy. The mean FCP levels before and after polypectomy were 277±247 µg/g (range, 80-1,000 µg/g) and 48.57±38.23 µg/g (range, 29-140 µg/g) (p<0.001), respectively. The FCP levels were significantly higher in patients with multiple polyps than in those with single polyps. Moreover, mean FCP levels in patients with single and multiple polyps were 207.6±172.4 µg/ g and 515.4±320.5 µg/g (p<0.001), respectively.
CONCLUSIONS: Colonic juvenile polyps were found to be associated with elevated levels of FCP that normalized after polypectomy. Therefore, FCP may be recommended as a noninvasive screening biomarker for diagnosis of colonic juvenile polyps.