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Abstract：
UNASSIGNED: We aimed to investigate factors that correlate with fecal calprotectin (FC) levels in children and adolescents with colorectal polyps.
UNASSIGNED: Pediatric patients aged <19 years who underwent colonoscopic polypectomy for a juvenile polyps (JPs) and FC tests were simultaneously conducted in a multicenter, retrospective study. Baseline demographics, colonoscopic and histological findings, and laboratory tests, including FC levels, were investigated. Correlations between the factors were investigated, and linear regression analysis revealed factors that correlated with FC levels. FC levels measured after polypectomies were investigated and the FC levels pre- and post-polypectomies were compared.
UNASSIGNED: A total of 33 patients were included in the study. According to Pearson correlation analysis, the polyp size was the only factor that showed a statistically significant correlation with FC levels (r=0.75, p<0.001). Furthermore, according to the multivariate linear regression analysis, polyp size was the only factor that showed a statistically significant correlation with FC levels (adjusted R2 =0.5718, β=73.62, p<0.001). The median FC level was 400 mg/kg (interquartile range [IQR], 141.6-1,000 mg/kg), and the median polyp size was 14 mm (IQR, 9-20 mm). Nineteen patients underwent post-polypectomy FC tests. FC levels showed a significant decrease after polypectomy from a median of 445.2 mg/kg (IQR, 225-1,000) to 26.5 mg/kg (11.5-51) (p<0.001).
UNASSIGNED: FC levels significantly correlated with polyp size in children and adolescents with JPs.
UNASSIGNED: Pediatric patients aged <19 years who underwent colonoscopic polypectomy for a juvenile polyps (JPs) and FC tests were simultaneously conducted in a multicenter, retrospective study. Baseline demographics, colonoscopic and histological findings, and laboratory tests, including FC levels, were investigated. Correlations between the factors were investigated, and linear regression analysis revealed factors that correlated with FC levels. FC levels measured after polypectomies were investigated and the FC levels pre- and post-polypectomies were compared.
UNASSIGNED: A total of 33 patients were included in the study. According to Pearson correlation analysis, the polyp size was the only factor that showed a statistically significant correlation with FC levels (r=0.75, p<0.001). Furthermore, according to the multivariate linear regression analysis, polyp size was the only factor that showed a statistically significant correlation with FC levels (adjusted R2 =0.5718, β=73.62, p<0.001). The median FC level was 400 mg/kg (interquartile range [IQR], 141.6-1,000 mg/kg), and the median polyp size was 14 mm (IQR, 9-20 mm). Nineteen patients underwent post-polypectomy FC tests. FC levels showed a significant decrease after polypectomy from a median of 445.2 mg/kg (IQR, 225-1,000) to 26.5 mg/kg (11.5-51) (p<0.001).
UNASSIGNED: FC levels significantly correlated with polyp size in children and adolescents with JPs.
摘要：
UNASSIGNED：我们旨在研究儿童和青少年结直肠息肉中与粪便钙卫蛋白（FC）水平相关的因素。
UNASSIGNED：19岁以下的儿童患者接受了幼年性息肉的结肠镜下息肉切除术（JP）和FC检查同时在多中心进行，回顾性研究。基线人口统计，结肠镜和组织学发现，和实验室测试，包括FC级别，被调查了。调查了各因素之间的相关性，线性回归分析揭示了与FC水平相关的因素。研究了息肉切除术后测量的FC水平，并比较了息肉切除术前后的FC水平。
UNASSIGNED：本研究共纳入33例患者。根据皮尔逊相关分析，息肉大小是唯一与FC水平有统计学显著相关性的因素(r=0.75,p<0.001).此外，根据多元线性回归分析，息肉大小是唯一与FC水平有统计学意义相关性的因素(调整后的R2=0.5718,β=73.62,p<0.001).FC水平中位数为400毫克/千克(四分位数间距[IQR]，141.6-1,000mg/kg），中位息肉大小为14毫米(IQR，9-20毫米)。19例患者接受了息肉切除术后FC检查。息肉切除术后FC水平显着下降，中位数为445.2mg/kg（IQR，225-1,000）至26.5mg/kg（11.5-51）（p<0.001）。
UNASSIGNED：FC水平与患有JP的儿童和青少年的息肉大小显著相关。
UNASSIGNED：19岁以下的儿童患者接受了幼年性息肉的结肠镜下息肉切除术（JP）和FC检查同时在多中心进行，
UNASSIGNED：本研究共纳入33例患者。
UNASSIGNED：FC水平与患有JP的儿童和青少年的息肉大小显著相关。
