在过去的五十年中,世界上的生物学家和化学家一直被海洋天然产物所吸引。从海洋生物中分离出大约16,000种海洋天然产品,这些产品已在大约6,800种出版物中报告。证明海洋微生物是生产新型抗生素的宝贵来源,抗肿瘤,和抗炎药。海洋真菌,特别是与海洋藻类有关的真菌,海绵,无脊椎动物,沉积物似乎是次生代谢物的丰富来源,拥有抗生素,抗病毒,抗真菌和抗酵母活性。此外,一些生长刺激特性可能对伤口愈合的研究有用,致癌特性,在癌症的研究中也有报道。最近对海洋丝状真菌寻找生物活性次级代谢产物的调查表明,它们作为新药来源的巨大潜力。本研究综述了从海洋真菌菌株中报道的一些重要的生物活性代谢产物,抗肿瘤和抗炎作用。它突出了主要生物活性生物碱的化学和生物活性,聚酮化合物,萜类化合物,类异戊二烯和非异戊二烯化合物,醌,从海洋真菌中分离出来。
Biologists and chemists of the world have been attracted towards marine natural products for the last five decades. Approximately 16,000 marine natural products have been isolated from marine organisms which have been reported in approximately 6,800 publications, proving marine microorganisms to be a invaluable source for the production of novel antibiotic, anti tumor, and anti inflammatory agents. The marine fungi particularly those associated with marine alga, sponge, invertebrates, and sediments appear to be a rich source for secondary metabolites, possessing Antibiotic, antiviral, antifungal and antiyeast activities. Besides, a few growth stimulant properties which may be useful in studies on wound healing, carcinogenic properties, and in the study of cancers are reported. Recent investigations on marine filamentous fungi looking for biologically active secondary metabolites indicate the tremendous potential of them as a source of new medicines. The present study reviews about some important bioactive metabolites reported from marine fungal strains which are anti bacterial, anti tumour and anti inflammatory in action. It highlights the chemistry and biological activity of the major bioactive alkaloids, polyketides, terpenoids, isoprenoid and non-isoprenoid compounds, quinones, isolated from marine fungi.