天然聚合物,特别是多糖,已被用作各种治疗剂如肽的药物递送系统,蛋白质,疫苗,DNA,以及用于肠胃外和非肠胃外给药的药物。壳聚糖,仅次于纤维素的第二丰富的天然多糖,是一种生物相容性和可生物降解的粘膜粘附聚合物,广泛用于制备纳米颗粒(NP)。发现装载有药物的壳聚糖NP是稳定的,渗透性和生物活性。在这次审查中,说明了壳聚糖及其衍生物在药物递送中的重要性,介绍了壳聚糖和壳聚糖衍生物NPs的不同制备方法及其理化性质。此外,成功的基于NP的药物递送系统的理想特征,以及这些NP的药物应用也被清楚地探索。
Natural polymers, particularly polysaccharide, have been used as drug delivery systems for a variety of therapeutic agents such as peptides, proteins, vaccines, DNA, and drugs for parenteral and non-parenteral administration. Chitosan, the second most abundant naturally occurring polysaccharide after cellulose, is a biocompatible and biodegradable mucoadhesive polymer that is extensively used in the preparation of nanoparticles (NPs). Chitosan NPs loaded with drugs were found to be stable, permeable and bioactive. In this
review, the importance of chitosan and its derivatives in drug delivery is illustrated, different methods of preparation of chitosan and chitosan derivatives NPs and their physio- chemical properties are addressed. Moreover, the desirable characteristics of successful NPs based drug delivery systems, as well as the pharmaceutical applications of these NPs are also clearly explored.