三萜类化合物是植物代谢产物中最多样化的化合物之一，它们具有多种生理活性，具有重要的经济价值。氧化角鲨烯环化酶催化2，3-氧化角鲨烯的环化，产生不同类型的甾醇和植物三萜类化合物，这对天然产物的结构多样性具有重要意义。然而,氧化角鲨烯环化酶催化的2，3-氧化角鲨烯多样化环化的机制尚不清楚。本文从催化功能方面综述了氧化角鲨烯环化酶的研究进展,基因和蛋白质之间的分子进化关系，蛋白质结构，分子模拟和分子计算，为三萜环化酶的蛋白质工程和代谢工程提供参考。
Triterpenoids are one of the most diverse compounds in plant metabolites, and they have a wide variety of physiological activities and are of important economic value. Oxidosqualene cyclases catalyze the cyclization of 2, 3-oxidosqualene to generate different types of sterols and plant triterpenoids, which is of great significance to the structural diversity of natural products. However, the mechanism of the diversified cyclization of 2, 3-oxidosqualene catalyzed by oxidosqualene cyclases remains unclear. This
review summarized the research progress of oxidosqualene cyclases from the aspects of catalytic function, molecular evolutionary relationship between genes and proteins, protein structure, molecular simulation and molecular calculations, which may provide a reference for protein engineering and metabolic engineering of triterpene cyclase.
