人畜共患疾病是主要的公共卫生问题,也是对人类健康的不可否认的威胁。在人畜共患疾病中,人畜共患病毒和病毒更难根除,因为它们会导致更高的感染率和死亡率。几项调查显示姜黄素,姜黄的活性成分,具有广谱特性,如抗微生物,抗血管,抗炎,抗肿瘤,抗肿瘤,抗氧化剂,和免疫系统调节剂的性质。在本研究中,我们对现有的计算机模拟进行了全面审查,在体外,以及PubMed中姜黄素和姜黄素的抗病毒(54种重要的人畜共患病毒)和抗pr病毒特性的体内证据,谷歌学者,科学直接,Scopus,和WebofScience数据库。数据库搜索产生了13,380个结果,其中216项研究符合纳入标准.在216项研究中,135(62.5%),24(11.1%),和19(8.8%)进行了姜黄素和姜黄素类抗SARS-CoV-2,甲型流感病毒的作用,还有登革热病毒,分别。这篇综述表明,姜黄素和姜黄素通过靶向不同的蛋白质和信号通路,可以作为针对多种病毒性人畜共患病的有希望的治疗剂。
Zoonotic diseases are major public health concerns and undeniable threats to human health. Among Zoonotic diseases, zoonotic viruses and prions are much more difficult to eradicate, as they result in higher infections and mortality rates. Several investigations have shown curcumin, the active ingredient of turmeric, to have wide spectrum properties such as anti-microbial, anti-vascular, anti-inflammatory, anti-tumor, anti-neoplastic, anti-oxidant, and immune system modulator properties. In the present study, we performed a comprehensive
review of existing in silico, in vitro, and in vivo evidence on the antiviral (54 important zoonotic viruses) and anti-prion properties of curcumin and curcuminoids in PubMed, Google Scholar, Science Direct, Scopus, and Web of Science databases. Database searches yielded 13,380 results, out of which 216 studies were eligible according to inclusion criteria. Of 216 studies, 135 (62.5%), 24 (11.1%), and 19 (8.8%) were conducted on the effect of curcumin and curcuminoids against SARS-CoV-2, Influenza A virus, and dengue virus, respectively. This
review suggests curcumin and curcuminoids as promising therapeutic agents against a wide range of viral zoonoses by targeting different proteins and signaling pathways.