PDF(Pubmed)
Abstract：
UNASSIGNED: Acute Necrotizing Encephalopathy (ANE), is a kind of severe Central Nervous System Disease. The commonest pathogen is the influenza virus. The pathogenesis of ANE is bound up to genetic susceptibility and cytokine storm. Interleukin-6 (IL-6) is deemed as the core function in cytokine storm of ANE and that plays a significant role in evaluating the severity of Influenza-Related ANE. Tocilizumab, an IL-6 antagonist, is known to be safe and effective in the treatment of ANE when used early and has an essential role in improving prognosis and preventing disability.
UNASSIGNED: This case reports a 2 year 10 month old boy who developed ANE after being infected with influenza A virus (H1N1-2019). After treatment with Tocilizumab, the child\'s consciousness was clear, no convulsions occurred, the movement of limbs was improved, and the lesions of encephalopathy were significantly reduced.
UNASSIGNED: The early use of Tocilizumab is safe and effective for the treatment of ANE caused by influenza virus.
UNASSIGNED: This case reports a 2 year 10 month old boy who developed ANE after being infected with influenza A virus (H1N1-2019). After treatment with Tocilizumab, the child\'s consciousness was clear, no convulsions occurred, the movement of limbs was improved, and the lesions of encephalopathy were significantly reduced.
UNASSIGNED: The early use of Tocilizumab is safe and effective for the treatment of ANE caused by influenza virus.
摘要：
■急性坏死性脑病（ANE），是一种严重的中枢神经系统疾病。最常见的病原体是流感病毒。ANE的发病机制与遗传易感性和细胞因子风暴有关。白细胞介素-6（IL-6）被认为是ANE细胞因子风暴的核心功能，在评估流感相关ANE的严重程度中起着重要作用。Tocilizumab,IL-6拮抗剂，众所周知，早期使用ANE治疗安全有效，对改善预后和预防残疾具有重要作用。
本病例报告一名2岁10个月大的男孩，在感染甲型流感病毒（H1N1-2019）后发展为ANE。用Tocilizumab治疗后，孩子的意识很清楚，没有发生抽搐,四肢的运动得到改善，脑病的病变明显减少。
■Tocilizumab的早期使用对于治疗由流感病毒引起的ANE是安全有效的。
本病例报告一名2岁10个月大的男孩，在感染甲型流感病毒（H1N1-2019）后发展为ANE。用Tocilizumab治疗后，孩子的意识很清楚，没有发生抽搐,四肢的运动得到改善，脑病的病变明显减少。
■Tocilizumab的早期使用对于治疗由流感病毒引起的ANE是安全有效的。
