PDF(Pubmed)
Abstract：
Influenza A virus (IAV) is the primary causative agent of influenza, colloquially called the flu. Each year, it infects up to a billion people, resulting in hundreds of thousands of human deaths, and causes devastating avian outbreaks with worldwide losses worth billions of dollars. Always present is the possibility that a highly pathogenic novel subtype capable of direct human-to-human transmission will spill over into humans, causing a pandemic as devastating if not more so than the 1918 influenza pandemic. While antiviral drugs for influenza do exist, they target very few aspects of IAV replication and risk becoming obsolete due to antiviral resistance. Antivirals targeting other areas of IAV replication are needed to overcome this resistance and combat the yearly epidemics, which exact a serious toll worldwide. This review aims to summarise the key steps in the IAV replication cycle, along with highlighting areas of research that need more focus.
摘要：
甲型流感病毒（IAV）是流感的主要病原体，俗称流感。每一年,它感染了多达10亿人，导致数十万人死亡，并造成毁灭性的禽流感疫情，全球损失达数十亿美元。始终存在的是一种能够直接人传人的高致病性新型亚型会蔓延到人类的可能性，造成大流行的破坏性甚至比1918年的流感大流行更大。虽然确实存在针对流感的抗病毒药物，它们针对的是IAV复制的很少方面,并且有可能由于抗病毒耐药性而过时.需要针对IAV复制的其他区域的抗病毒药物来克服这种耐药性并对抗每年的流行病。这在全球范围内造成了严重的损失。这篇综述旨在总结IAV复制周期中的关键步骤，同时突出需要更多关注的研究领域。
