生物活性苦杏仁苷,在苦杏仁中发现高浓度,已被公认为标志的氰化糖苷化学有机物质,它最初被开发为水解为氰化氢(HCN)后用于治疗癌症的药物。遗憾的是,研究表明,HCN也会损伤正常细胞,使其对人体无毒。围绕体内和体外研究的极端争议,使其使用具有风险。这篇评论提供了关于特征的广泛更新,抗氧化潜力,胃肠道微生物群干预,抗癌治疗,机制,毒性,和苦杏仁苷的封装。抗氧化剂,抗肿瘤,抗纤维化,抗动脉粥样硬化,抗炎,免疫调节,和镇痛特性,以及改善消化系统和生殖系统的能力,神经变性,和心脏肥大只是苦杏仁苷的一些好处。研究证实HCN产生的苦杏仁苷对口服有害,但只有非常高的剂量。虽然静脉治疗不如口服治疗有效,口服途径的剂量范围为每日0.6至1克。苦杏仁苷的毒性很大程度上取决于消化道中细菌的种类。不幸的是,目前没有万无一失的方法来确定微生物聚生体并为每位患者提供安全的口服剂量。海藻酸盐-壳聚糖纳米颗粒(ACNP)中的苦杏仁苷封装是一个相对较新的研究领域。苦杏仁苷对恶性细胞具有增强的细胞毒性作用,ACNP可以用作活性药物递送系统,以调节释放该化合物,持续的方式,而不会对健康的细胞或组织造成任何伤害。总之,由于未经证实和相互矛盾的数据,一个可能是癌症治疗下一步的物质的大范围研究被打开。
Bioactive amygdalin, found in high concentrations in bitter almonds, has been recognized as a symbol of the cyanogenic glycoside chemical organic substance, which was initially developed as a pharmaceutical for treating cancer after being hydrolyzed to hydrogen cyanide (HCN). Regrettably, research has shown that HCN can also damage normal cells, rendering it non-toxic to the human body. Extreme controversy surrounds both in vivo and in vitro studies, making its use risky. This
review provides an extensive update on characteristics, antioxidant potential, gastrointestinal microbiota intervention, anticancer therapeutic, mechanisms, toxicity, and encapsulation of amygdalin. Antioxidant, anti-tumor, anti-fibrotic, antiatherosclerosis, anti-inflammatory, immunomodulatory, and analgesic characteristics, and the ability to improve digestive and reproductive systems, neurodegeneration, and cardiac hypertrophy are just some of the benefits of amygdalin. Studies verified the HCN-produced amygdalin to be harmful orally, but only at very high doses. Although intravenous treatment was less effective than the oral method, the oral route has a dose range of 0.6 to 1 g daily. Amygdalin\'s toxicity depends heavily on the variety of bacteria in the digestive tract. Unfortunately, there is currently no foolproof method for determining the microbial consortium and providing a safe oral dosage for every patient. Amygdalin encapsulation in alginate-chitosan nanoparticles (ACNPs) is a relatively new area of research. Amygdalin has an enhanced cytotoxic effect on malignant cells, and ACNPs can be employed as an active drug-delivery system to release this compound in a regulated, sustained manner without causing any harm to healthy cells or tissues. In conclusion, a large area of research for a substance that might be the next step in cancer therapy is opened up due to unverified and conflicting data.