背景和目的1923-1927年是希腊历史上一个动荡的时期,在1922年9月希腊军队惨败之后,被称为“亚洲小灾难”。塞萨洛尼基的大规模难民定居点,希腊,带来了巨大的经济,公共卫生,和社会挑战。当前的历史流行病学研究旨在评估上述期间在塞萨洛尼基的“AgiosDimitrios”医院住院的个人的疾病。材料和方法本研究涉及在医院治疗的15,146名连续患者(1923年1月至1927年3月)。数据从塞萨洛尼基总医院“AgiosDimitrios”收集,并手动输入预编码数据库。计算描述性统计数据。此外,计算了病死率(CFR);估计了各自的95%置信区间(CI).结果入院的最常见原因如下:正常分娩/无后遗症的分娩(n=1915,12.7%),其次是结核病(n=1514,10.0%),疟疾(n=1438,9.5%),受伤/跌倒/骨折(n=1394,9.2%),肺炎/胸膜炎(n=1010,6.7%),阑尾炎(n=623,4.1%),痢疾/小肠结肠炎/伤寒(n=489,3.2%),输卵管炎/输卵管卵巢炎(n=358,2.4%),软组织脓肿(n=309,2.0%),疝气(n=295,2.0%),狂犬病(n=239,1.6%),子宫出血/月经过多(n=233,1.5%),眼白内障(n=225,1.5%),产后感染/子宫内膜炎(n=181,1.2%),子宫不适/子宫疼痛(n=162,1.1%),肾炎/尿毒症(n=157,1.0%),流产(n=155,1.0%),不包括脓肿的皮肤感染/炎症(n=152,1.0%),中耳炎/乳突炎/迷路炎(n=96,0.6%),和消化性溃疡(n=93,0.6%)。结核病尤其与高CFR相关(49.5%,95%CI:47.2-52.3%),其次是肾炎/尿毒症(CFR:37.6%),痢疾/感染性小肠结肠炎/伤寒(CFR:24.3%),消化性溃疡(CFR:22.6%),肺炎/胸膜炎(CFR:16.1%),产后感染/子宫内膜炎(CFR:15.5%)。结论住院人群疾病谱中以感染为主。记录在案的死亡率很高;不良结果可能反映了当时的社会经济逆境以及有限的医疗手段和资源。
Background and objective The period spanning 1923-1927 was a turbulent period in Greek history following the catastrophic defeat of the Greek army in September 1922, known as the \"Asia Minor Catastrophe\". The massive settlement of refugees in Thessaloniki, Greece, entailed massive economic, public health, and social challenges. The present historical-epidemiological
study aims to evaluate the diseases of individuals hospitalized at the \"Agios Dimitrios\" Hospital in Thessaloniki during the aforementioned period. Materials and methods This
study involved 15,146 consecutive patients (January 1923-March 1927) treated at the hospital. Data were collected from the General Hospital of Thessaloniki \"Agios Dimitrios\" and were manually entered into a pre-coded database. Descriptive statistics were calculated. In addition, the case fatality rates (CFR) were calculated; the respective 95% confidence intervals (CI) were estimated. Results The most frequent causes for admission to the hospital were as follows: normal delivery/delivery without disclosed sequalae (n=1915, 12.7%), followed by tuberculosis (n=1514, 10.0%), malaria (n=1438, 9.5%), injuries/falls/fractures (n=1394, 9.2%), pneumonia/pleuritis (n=1010, 6.7%), appendicitis (n=623, 4.1%), dysentery/enterocolitis/typhoid (n=489, 3.2%), salpingitis/salpingo-oophoritis (n=358, 2.4%), soft tissue abscesses (n=309, 2.0%), hernias (n=295, 2.0%), rabies (n=239, 1.6%), metrorrhagia/menorrhagia (n=233, 1.5%), ocular cataract (n=225, 1.5%), postpartum infections/endometritis (n=181, 1.2%), uterine discomfort/uterine pain (n=162, 1.1%), nephritis/uremia (n=157, 1.0%), miscarriage (n=155, 1.0%), skin infections/inflammations excluding abscesses (n=152, 1.0%), otitis/mastoiditis/labyrinthitis (n=96, 0.6%), and peptic ulcer (n=93, 0.6%). Tuberculosis was particularly associated with high CFR (49.5%, 95% CI: 47.2-52.3%), followed by nephritis/uremia (CFR: 37.6%), dysentery/infectious enterocolitis/typhoid (CFR: 24.3%), peptic ulcer (CFR: 22.6%), pneumonia/pleuritis (CFR: 16.1%), postpartum infections/endometritis (CFR: 15.5%). Conclusions Infections predominated in the disease spectrum of the hospitalized population. The documented fatality rates were high; poor outcomes may reflect the socioeconomic adversities and limited medical means and resources available at that time.