History of medicine

医学史
  • 文章类型: Journal Article
    本文讨论了合作研究和作者争议的历史背景,以荷兰解剖学和内科医生GerardL.Blaes和他的东欧-中欧学员之间的复杂关系为例,DanielGödtke,在脊髓延髓研究期间。这项研究采用历史分析来解开学术合作的动力,强调指导在科学进步中的重要性和知识交流的社区性。此历史分析基于主要来源和历史记录。它强调了Blaes规避关于开创性作品“Anatome延髓脊髓脊髓”作者身份的公众对抗的策略,埃特纳弗兰。作为一名教师,他促进了他的学生参与公开争论,以避免公众对这本书的作者冲突。这最终导致了两种不同版本的Anatome延髓脊髓的出版。\'第一个是由导师和他的受训者共同创作的,而后者完全归因于导师。这种历史叙事提出了关于在医学科学中归因于个人贡献的基本问题,呼应当代学术界仍然相关的担忧。此外,它使教师与学生关系中固有的权力动态以及作者争议对学者声誉的潜在影响可见。通过将历史和现代作者身份困境相提并论,这项研究有助于正在进行的关于科学研究和出版中公平作者身份的讨论。它不仅突出了导师-受训者合作和作者纠纷的复杂动态的历史先例,而且还阐明了这些做法如何继续影响当代学术和出版习俗。
    This paper discusses the historical context of collaborative research and authorship disputes, exemplified by the complex relationship between Dutch anatomist and physician Gerard L. Blaes and his East-Central European mentee, Daniel Gödtke, during the study of medulla spinalis. The study employs historical analysis to unravel the dynamics of scholarly collaboration, emphasizing the significance of mentorship in scientific progress and the communal nature of knowledge exchange. This historical analysis is based on primary sources and historical records. It underscores Blaes\'s strategy to circumvent public confrontations regarding the authorship of the seminal work \'Anatome medullae spinalis, et nervorum inde provenientium\' (1666). As a teacher, he facilitated his student\'s participation in a public disputation to avert public authorship conflicts over the book. This ultimately led to the publication of two distinct versions of \'Anatome medullae spinalis.\' The first one was co-authored by the mentor and his mentee, while the latter was solely attributed to the mentor. This historical narrative raises essential questions about attributing individual contributions in medical sciences, echoing concerns still pertinent in contemporary academia. Additionally, it makes visible the power dynamics inherent in faculty-students relationships and the potential repercussions of authorship disputes on scholars\' reputations. By drawing parallels between historical and modern authorship dilemmas, this study contributes to ongoing discussions on equitable authorship in scientific research and publishing. It not only highlights a historical precedent for the complex dynamics of mentor-mentee collaborations and authorship disputes but also illuminates how these practices continue to influence contemporary academic and publishing customs.
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  • 文章类型: English Abstract
    1992年是俄罗斯医药市场历史上的重要里程碑。它不是从一月份开始的,但是在1991年12月,总统和政府颁布了开放药品自由市场的命令。叶利钦顾问认为,市场经济是应对药物短缺的可靠手段,腐败和官僚垄断。然而,万灵药不起作用。此外,它引起了全新的问题。人类和国家安全意味着免受依赖威胁。毫无准备的进入市场使俄罗斯人和该国严重依赖进口药物和外国制药公司。这项拟议的研究在2022年在本杂志和“Pharmacia”杂志上发表了我们的出版物。当时,对药物“饥荒”的分析是根据已发表的资料来源实施的,并依赖于新闻证据。本研究是根据俄罗斯联邦卫生部的档案文件和作者对监管机构代表的采访进行的。第一份报告揭示了在我国后苏联时代的第一年引起药物供应危机的行政机制。
    The year 1992 is an important landmark in the history of Russian pharmaceutical market. It began not in January, but in December 1991, when orders of the President and the Government to open free market of medications were promulgated. The Yeltsin advisers conceived that market economy was infallible means to combat medication shortages, corruption and bureaucratic monopoly. However, panacea did not work. Moreover, it gave rise to completely new problems. The human and state security implies protection from threats of dependence. The unprepared dive into market plunged Russians and the country into deep dependence on imported medications and foreign pharmaceutical companies. The proposed study proceeds our publications in this journal and in journal \"Pharmacia\" in 2022. At that time, analysis of medication \"famine\" was implemented on basis of published sources and relied on journalistic evidences. The current study was carried out on the basis of archive documents of the Ministry of Health of the Russian Federation and authors interviews of representatives of the regulator. The first report reveals administrative mechanism that engendered crisis of medication supply in the first post-Soviet year of our country.
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  • 文章类型: Journal Article
    背景:当女性和种族个体被排除在医学之外时,许多医学上的大名被确立。这项研究的目的是确定其名字被纳入医学地名的个人的性别和种族化状况。
    方法:本研究是对医学地名名称的性别和种族化的横断面分析。主要结果指标是在Whonamedit中发现的医学地名名称的性别和种族化研究,莫斯比的医学词典,和国际疾病分类(第10版)。使用图片和其他可用信息确定性别以及该个人是否是种族化的人。
    结果:我们确定了3484个独特的地名。白人男性占医学地名名称的大多数(2327人中的2190人,占94.1%),其次是白人女性(2327人中的85人,占3.7%),种族化男性(2327人中有49人,占2.1%),和种族化妇女(2327人中有3人,占0.1%)。在ICD-10子分析中,白人男性占大多数的医学地名名称(514人中的476人,92.6%),其次是白人女性(514人中的22人,4.3%),种族化男性(514人中有14人,2.7%),和种族化妇女(514人中有2人,0.4%)。
    结论:大多数医学地名代表男性和白人,强调妇女和种族化个人的代表性不足。这表明有必要重新审查医学大写字母的持续使用,这可能会加剧医学中的性别歧视和种族主义,并助长使某些人感到不受欢迎或被低估的环境。
    BACKGROUND: Many medical eponyms were established when women and racialized individuals were excluded from medicine. The objective of this study was to determine the gender and racialization status of individuals whose names are incorporated in medical eponyms.
    METHODS: This study is a cross-sectional analysis of gender and racialization of medical eponym namesakes. The main outcome measures were the study of gender and racialization of medical eponym namesakes found in Whonamedit, Mosby\'s Medical Dictionary, and the International Classification of Diseases (version 10). The gender and whether the individual was a racialized person were determined using pictures and other available information.
    RESULTS: We identified 3484 unique eponyms. White men represented the majority of medical eponym namesakes (2190 of 2327, 94.1%) followed by white women (85 of 2327, 3.7%), racialized men (49 of 2327, 2.1%), and racialized women (3 of 2327, 0.1%). In the ICD-10 sub-analysis, white men represented the majority of medical eponym namesakes (476 of 514, 92.6%) followed by white women (22 of 514, 4.3%), racialized men (14 of 514, 2.7%), and racialized women (2 of 514, 0.4%).
    CONCLUSIONS: Most medical eponyms represent men and white individuals, highlighting the underrepresentation of women and racialized individuals. This indicates a need to re-examine the ongoing use of medical eponyms which may entrench sexism and racism in medicine and contribute to an environment that makes some feel unwelcome or undervalued.
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  • 文章类型: Journal Article
    背景和目的1923-1927年是希腊历史上一个动荡的时期,在1922年9月希腊军队惨败之后,被称为“亚洲小灾难”。塞萨洛尼基的大规模难民定居点,希腊,带来了巨大的经济,公共卫生,和社会挑战。当前的历史流行病学研究旨在评估上述期间在塞萨洛尼基的“AgiosDimitrios”医院住院的个人的疾病。材料和方法本研究涉及在医院治疗的15,146名连续患者(1923年1月至1927年3月)。数据从塞萨洛尼基总医院“AgiosDimitrios”收集,并手动输入预编码数据库。计算描述性统计数据。此外,计算了病死率(CFR);估计了各自的95%置信区间(CI).结果入院的最常见原因如下:正常分娩/无后遗症的分娩(n=1915,12.7%),其次是结核病(n=1514,10.0%),疟疾(n=1438,9.5%),受伤/跌倒/骨折(n=1394,9.2%),肺炎/胸膜炎(n=1010,6.7%),阑尾炎(n=623,4.1%),痢疾/小肠结肠炎/伤寒(n=489,3.2%),输卵管炎/输卵管卵巢炎(n=358,2.4%),软组织脓肿(n=309,2.0%),疝气(n=295,2.0%),狂犬病(n=239,1.6%),子宫出血/月经过多(n=233,1.5%),眼白内障(n=225,1.5%),产后感染/子宫内膜炎(n=181,1.2%),子宫不适/子宫疼痛(n=162,1.1%),肾炎/尿毒症(n=157,1.0%),流产(n=155,1.0%),不包括脓肿的皮肤感染/炎症(n=152,1.0%),中耳炎/乳突炎/迷路炎(n=96,0.6%),和消化性溃疡(n=93,0.6%)。结核病尤其与高CFR相关(49.5%,95%CI:47.2-52.3%),其次是肾炎/尿毒症(CFR:37.6%),痢疾/感染性小肠结肠炎/伤寒(CFR:24.3%),消化性溃疡(CFR:22.6%),肺炎/胸膜炎(CFR:16.1%),产后感染/子宫内膜炎(CFR:15.5%)。结论住院人群疾病谱中以感染为主。记录在案的死亡率很高;不良结果可能反映了当时的社会经济逆境以及有限的医疗手段和资源。
    Background and objective The period spanning 1923-1927 was a turbulent period in Greek history following the catastrophic defeat of the Greek army in September 1922, known as the \"Asia Minor Catastrophe\". The massive settlement of refugees in Thessaloniki, Greece, entailed massive economic, public health, and social challenges. The present historical-epidemiological study aims to evaluate the diseases of individuals hospitalized at the \"Agios Dimitrios\" Hospital in Thessaloniki during the aforementioned period. Materials and methods This study involved 15,146 consecutive patients (January 1923-March 1927) treated at the hospital. Data were collected from the General Hospital of Thessaloniki \"Agios Dimitrios\" and were manually entered into a pre-coded database. Descriptive statistics were calculated. In addition, the case fatality rates (CFR) were calculated; the respective 95% confidence intervals (CI) were estimated. Results The most frequent causes for admission to the hospital were as follows: normal delivery/delivery without disclosed sequalae (n=1915, 12.7%), followed by tuberculosis (n=1514, 10.0%), malaria (n=1438, 9.5%), injuries/falls/fractures (n=1394, 9.2%), pneumonia/pleuritis (n=1010, 6.7%), appendicitis (n=623, 4.1%), dysentery/enterocolitis/typhoid (n=489, 3.2%), salpingitis/salpingo-oophoritis (n=358, 2.4%), soft tissue abscesses (n=309, 2.0%), hernias (n=295, 2.0%), rabies (n=239, 1.6%), metrorrhagia/menorrhagia (n=233, 1.5%), ocular cataract (n=225, 1.5%), postpartum infections/endometritis (n=181, 1.2%), uterine discomfort/uterine pain (n=162, 1.1%), nephritis/uremia (n=157, 1.0%), miscarriage (n=155, 1.0%), skin infections/inflammations excluding abscesses (n=152, 1.0%), otitis/mastoiditis/labyrinthitis (n=96, 0.6%), and peptic ulcer (n=93, 0.6%). Tuberculosis was particularly associated with high CFR (49.5%, 95% CI: 47.2-52.3%), followed by nephritis/uremia (CFR: 37.6%), dysentery/infectious enterocolitis/typhoid (CFR: 24.3%), peptic ulcer (CFR: 22.6%), pneumonia/pleuritis (CFR: 16.1%), postpartum infections/endometritis (CFR: 15.5%). Conclusions Infections predominated in the disease spectrum of the hospitalized population. The documented fatality rates were high; poor outcomes may reflect the socioeconomic adversities and limited medical means and resources available at that time.
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  • 文章类型: Journal Article
    跨学科合作被认为是一种理想的研究方式,在某些情况下,甚至对学术团队和资助提案的要求。本文探讨了可能性,还有问题,通过Ancientbiotics团队的案例研究,不同学科之间的合作。该团队探索了历史医学食谱中天然产品的潜力。在不寻常的地方寻找临床上有用的天然产物,比如历史医学实践,是科学学科中公认的努力。Ancientbiotics合作,主要基于英国机构,在将天然产品的现代科学知识与人文学科的专业知识相结合以确定成分组合方面,这条道路向前迈出了一步。经过7年的实践,这项研究产生了各种各样的结果。这个观点将探讨团队如何在跨学科框架内工作,以推进历史医学食谱的调查和应用。
    Interdisciplinary collaboration is regarded as a desirable way of researching and, in some instances, even a requirement for academic teams and funding proposals. This paper explores the possibilities, but also the problems, of collaboration between different disciplines through a case study of the Ancientbiotics team. This team explores the potential of natural products contained in historical medical recipes. The search for clinically useful natural products in unusual places, such as historical medical practices, is a well-established endeavor in the scientific disciplines. The Ancientbiotics collaboration, largely based across UK institutions, takes this path a step forward in combining modern scientific knowledge of natural products with expertise from humanities to identify ingredient combinations. After 7 years of practice, the research has produced a variety of outcomes. This perspective will explore how the team worked within an interdisciplinary framework to advance investigation and application of historical medical recipes.
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  • 文章类型: Journal Article
    Currently, life expectancy is increasing every year, and with it the diseases that are characteristic of the elderly. Dementia is one such condition. According to statistics, there are 9 people with dementia per 100 healthy people aged 60 and over. However, it is important to understand that dementia can also be viewed in a historical context. Over time, ideas about this condition, approaches to its management, as well as the attitude of society towards patients with dementia have changed. The article describes the history of the study of dementia, which went along with the development of medicine, anatomy, neurology and psychiatry. In different historical periods, people\'s understanding of the mechanisms of development, etiology and pathogenesis of this condition has changed. Ethics and deontology gradually developed, which undoubtedly played an important role in improving the life of not only patients with dementia, but also the relationship between the doctor and the patient as a whole. The main stages in the study of dementia have become the basis for the modern understanding of this condition.
    В настоящее время продолжительность жизни увеличивается с каждым годом, но вместе с ней растет и число заболеваний, характерных для пожилых людей. Деменция — одно из таких состояний. Согласно статистическим данным, на 100 здоровых человек в возрасте 60 лет и старше приходятся 9 лиц, имеющих деменцию разной степени тяжести. Вопросы деменции можно рассматривать и в историческом контексте. С течением времени менялись представления об этом состоянии, подходы к его лечению, а также отношение общества к больным деменцией. В статье описывается история изучения деменции, которая шла параллельно с развитием анатомии, неврологии и психиатрии. В разных исторических промежутках менялось понимание механизмов развития, этиологии и патогенеза данного состояния. Постепенно развивались этика и деонтология, что несомненно сыграло важную роль не только для улучшения жизни пациентов с деменцией, но и отношений врача и пациента. Основные этапы изучения деменции стали основой для современного представления о данном состоянии.
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  • 文章类型: Historical Article
    历史混淆了何塞·曼努埃尔·罗德里格斯·德尔加多和沃尔特·弗里曼的遗产,20世纪中叶神经精神疾病躯体疗法的支持者。两者都声名狼藉:德尔加多出现在《纽约时报》的头版上,他利用自己的沉默感阻止了西班牙的一头公牛;弗里曼是白质切除术的支持者。两者都是反精神病学运动批评的对象,也是那些认为其方法和目标对人身自由构成威胁的人。使用档案来源,我们证明了这种混淆是对历史记录的错误陈述,目标,伦理,和哲学承诺差异很大。关于历史先例的准确知识是道德分析的谓词,并且随着神经科学为帕金森氏症等疾病开发基于电路的治疗方法而成为特别相关的信息,抑郁症,和脑损伤。纠正措施的一部分是为了消除德尔加多和弗里曼的生活和工作的混淆。欣赏他们独特的遗产可以帮助指导今天完成的神经精神病学研究,这些研究可能会困扰后代。
    History has conflated the legacies of José Manuel Rodríguez Delgado and Walter Freeman, midcentury proponents of somatic therapies for neuropsychiatric conditions. Both gained notoriety: Delgado after he appeared on the front page of the New York Times having used his stimoceiver to stop a charging bull in Spain; Freeman as the proponent of lobotomy. Both were the object of critique by the antipsychiatry movement and those who felt that their methods and objectives posed a threat to personal liberty. Using archival sources, we demonstrate that this conflation is a misrepresentation of the historical record and that their methods, objectives, ethics, and philosophical commitments differed widely. Accurate knowledge about historical antecedents is a predicate for ethical analysis and becomes especially relevant information as neuroscience develops circuit-based treatments for conditions such as Parkinson disease, depression, and brain injury. Part of that corrective is to counter the conflation of Delgado\'s and Freeman\'s life and work. Appreciating their distinctive legacies can help guide neuropsychiatric research done today that might yet haunt future generations.
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  • 文章类型: Journal Article
    本文旨在探讨社会对麻风病人的污名和社会偏见,还要了解这种传染病如何在很大程度上影响人类的生活方式和进化,分析其治疗方法从过去的经验治疗到实际的多药物治疗(MDT)的演变。使用PubMed,WebofScience,Medline,施普林格链接和爱思唯尔(EMBASE.com)数据库,而且在医学上,宗教和考古书籍。麻风病在世界各地传播,遵循人类从非洲大陆迁移到亚洲大陆和欧洲的路径,相反,它在新大陆的出现是最近的。战争,不卫生的条件,自史前时代以来,社会和健康不平等为其蔓延创造了条件,现有的健康差距导致了不平等的发病率和死亡率,在中世纪后由于其他更严重的流行病的增加而逐渐下降之前。从文艺复兴开始,对其病理生理机制的更深入了解带来了越来越先进的手术和药物联合治疗,但是在现代,人们仍然做出了许多努力来消除其社会污名,改名为“汉森病”。
    This article aims to investigate about the social stigma and the prejudice of society towards the patients with leprosy, but also to understand how this infectious disease has largely influenced human lifestyle and evolution analyzing the evolution of its treatments from past empirical treatments to actual multidrug therapy (MDT). References on leprosy were extensively searched in literature using PubMed, Web of Science, Medline, Springer link and Elsevier\'s (EMBASE.com) databases, but also in medical, religious and archaeological books. Leprosy\'s spread all around the world following human paths of migration from the African Continent to the Asian one and to Europe, instead its appearance in the New Continent is more recent. Wars, unhygienic conditions, social and health inequality created conditions for its spread since prehistorical times, and existing health disparities contributed to unequal morbidity and mortality, before its gradual decline after the Middle Ages due to the raise of other worse pandemics. Starting from Renaissance, a deeper knowledge on its pathophysiological mechanisms brought an increasingly advanced combined surgical and pharmacological treatment, but still in modern times many efforts have been made to erase its social stigma, changing its name in \"Hansen\'s disease\" included.
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  • 文章类型: Journal Article
    With the current COVID-19 pandemic that humanity is experiencing and the mobilization of all health systems to exercise sanitary measures such as quarantines and other measures to reduce infections, it should be remembered that these practices have been possible thanks to the experiences that in hygiene matters we have accumulated in our history. This essay aims to highlight about hygiene, the historicity of the concept, and its object of study as a medical discipline, in medical texts published in Spain during the 19th century, to help us understand the contributions of this science to current clinical practice and for these purposes, the bibliographic material was obtained from the National Library of Spain.
    Con la actual pandemia de COVID-19 que la humanidad vive y la movilización de todos los sistemas de salud para ejercer medidas sanitarias, como los confinamientos, las cuarentenas y otras medidas para disminuir los contagios, vale la pena recordar que estas prácticas han sido posibles por las experiencias que en materia de higiene hemos acumulado en nuestra historia. Este ensayo tiene como objetivo destacar la higiene, la historicidad del concepto y su objeto de estudio como disciplina médica, en textos publicados en España en el siglo XIX, para ayudarnos a entender los aportes de esta ciencia a la práctica clínica actual. Con tales fines se obtuvo el material bibliográfico en la Biblioteca Nacional de España.
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  • 文章类型: Historical Article
    BACKGROUND: History courses are \"required\" elements among the didactic elements of the medical and pharmacy curricula in many schools around the world. The aim of this study was to develop consensus-based aims, contents, intended learning outcomes, teaching, and evaluation methods of a history of medicine and pharmacy course for medical and pharmacy students in the Arab World.
    METHODS: A systematic search of PubMed, ScienceDirect, SpringerLink, Scopus, and Google Scholar was conducted to identify course aims, contents, intended learning outcomes from the literature. The search was supplemented by semi-structured in-depth interviews with 5 educators/academicians, 3 pharmacists, and 3 physicians. The Delphi technique was used among panelists (10 educators/academicians, 4 physicians, and 4 pharmacists) to develop consensus-based course aims, contents, intended learning outcomes, teaching, and evaluation methods.
    RESULTS: The vast majority of the panelists agreed on the 10 items (agreement ≥88.9%) on the importance of teaching history to medical and pharmacy students. Consensus-based aims (n = 4) and intended learning outcomes (n = 13) were developed in the 1st and 2nd iterative Delphi rounds. The panelists suggested that 16 dedicated meeting hours (1 credit hour) would be required to cover the course. Bloom\'s verbs were used to target the lower and higher orders of the cognitive domain. The course could be taught through face-to-face lectures, provision of reading materials, video documentaries, case studies, group discussions and debates. Multiple-choice questions, written reflections, portfolios, group projects, and engagement in discussions and debates might be used to evaluate performance of students.
    CONCLUSIONS: Consensus-based course of history of medicine and pharmacy course was developed for medical and pharmacy students in the Arab World. Well-designed course aims, contents, intended learning outcomes, teaching, and evaluation methods are more likely to meet the accreditation requirements and might improve performance of medical and pharmacy students. Future studies are still needed to investigate if such consensus-based courses can improve performance of the students.
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