Infection control remains a significant burden for healthcare systems. The irrational use of antibiotics in the fight against microbial diseases has led to the fast development of antimicrobial resistance. Considering how the latter can adversely influence the effectiveness of modern treatments and the way medicine is practiced, we should revise the events that led to the establishment of the general principles of antisepsis and pay special tribute to the people who contributed to their formation, bearing in mind that they remain unmodified to a great extent until today. Without Semmelweis\' conceptualization of the idea of direct transmission of sepsis, Pasteur\'s emblematic figure that helped promote the idea even further, and Lister\'s methodology structuring, the scientific community would have significantly delayed winning the battle against germs.

The publication is the only monograph in Russia devoted to description of history of development of irreversible non-selective inhibitors of mono-amine oxidase. It is the first group of antidepressants becoming available for physicians to be applied in clinical practice. The necessity of such publications is obvious because information presented through history perspective permits to better understand process of formation of modern practical guidelines of applying psychotropic drugs. The monograph presents well structured thorough systematization and detailed analysis of data of history of irreversible non-selective inhibitors of mono-amine oxidase. The text includes multitude of facts of scientific interest. For example, application of drug in the USSR, Russia and other countries of post-Soviet space, input of specialists from these countries into development of psycho-pharmacotherapy, experience of using inhibitors of mono-amine oxidase in treatment of somatic diseases. In addition, every chapter presents many historical excursus into important general psychiatric and even general medical issues. The monograph undoubtedly will arise interest among psychiatrists, neurologists, pharmacologists, etc.

BACKGROUND: Humans have always referred to religion in History to explain disasters, and epidemics, especially when science could not explain them. Religion has often been invoked as a mean of protection. The Covid outbreak in 2020 and the initial medical impotence brought up old fears, reminiscent of the plague for some people. Unable to rely on science only, some turned back to religion.
METHODS: A narrative review was conducted to compare the role of religion during the Great Plague of Marseille versus the early stages of Covid-19 pandemic. We mostly studied contemporary documents on the Great Plague of Marseille, and collected press articles on Covid-19.
CONCLUSIONS: For both epidemics, some people see in the outbreak a sign of God\'s revenge. Logically, intensifying spiritual life and multiplying religious demonstrations can be a way to fight both epidemics. Studying religion in these times of epidemics also highlights its roles in public health: sometimes facilitating the contaminations if not regulated, sometimes supporting public health policies with some positions, as for Covid vaccines. Conclusion/Perspectives: The comparison of an ancient epidemic with the current pandemic allowed us to take a broader look at the current vision of contagious disease, in societies that have become highly medicalized. The fight against epidemics remains polymorphous, and one of the aspects is religious. Integrating this information in our practices can help improving holistic management of patients, and public health policies efficiency.

UNASSIGNED: In the early 20th century, psychosurgery had gained worldwide popularity for treating mentally ill persons, especially in western countries. We attempt to chronicle its journey in the Mysore Government Mental Hospital (MGMH), now the National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru.
UNASSIGNED: Archived case records and registers of patients admitted from 1939 to 1947 were reviewed to identify those who had undergone psychosurgery. Case records of the identified patients were assessed for clinical information, including the details of psychosurgery.
UNASSIGNED: Among the patients, 107 had undergone psychosurgery, primarily leucotomy. Schizophrenia (51.5%) was the most common diagnosis in them, and 33.7% of all patients were reported to have improved. Yet, inconsistencies were found about the presence and degree of improvement. Possible side effects were not consistently documented.
UNASSIGNED: Psychosurgery was adopted at the MGMH very soon following its introduction in the western world. However, ambiguity about its benefits and risks was noted in the current study.

Saim Erkun (1901-1949) was born in Manisa at Aegean region of Anatolia as an Ottoman citizen. While his early life was spent in late Ottoman times at military actions including military prison camp in British colony; India, his active professional productive period was in early Turkish republic period (Est. 1923, centenary). He had a good education period for medicine with the help of his good level of all main World scientific languages such as French, German, and English. Besides his main profession, he was also interested in Ottoman urological medicine around the conquer of Istanbul and allocated them a space in his books in 1930s. He was one of the earliest urology resident (1929-1933, Istanbul) of modern medicine in Turkey. He performed many urological procedures and published the outcomes following modern scientific algorithms, furthermore, there have been urological books including \"history\" partly referring to antique Ottoman literature among his publications. In this manuscript we focused on the magic word of Urology forever; \"Prostate,\" among his essays. Turkish medicine, particularly urology, renewed itself by some intelligent hard working young clinicians such as Saim Erkun, immediately after the short struggling by means of establishment process of modern Turkiye after World War I by the collapsing of old Ottoman Empire. Furthermore, we think that the stunning special word of urology, \"prostate,\" should especially be mentioned to emphasize the importance of this beginning.

While robotic-assisted surgery is in a Renaissance, telesurgery, facilitated by robotic technology, is evolving in the space between innovative and mainstream clinical practice. This article outlines the current utilization of robotic telesurgery and barriers to adoption, and it performs a systematic review of relevant ethical concerns. It illustrates how telesurgery can be developed to provide safe, equitable, and high quality surgical care.

Since its foundation, the Faculty of Medical Sciences (FCM, UNC, Argentina) and its members in the design and implementation of eugenic public policies aimed at preventing depopulation and reducing infant mortality. This study describes these policies since the foundation of this institution until the outbreak of the university reform process.
A bibliographical analysis of online databases and library catalogs was performed in order to identify texts referring to child care and public health policies promoted by the FCM from 1877 to 1918. Results: 11 bibliographical references were obtained: three books, two scientific journal articles and six Thesis for the title of Doctor in Medicine and Surgery from the FCM.
A great interest in the characterization of infant mortality in Córdoba and the promotion of exclusive breastfeeding is evident in the texts analyzed. This is associated with the creation and administration of childcare health institutions, including the Children\'s Protective Clinic.
The FCM, associated to political groups in Córdoba, actively participated in the dissemination of childcare concepts (whose recipients were mainly women-mothers of low socioeconomic strata) and in the implementation of actions aimed at the population growth and the inculcation of moral values accepted by its academics.
Desde su fundación, la Facultad de Ciencias Médicas (FCM, UNC, Argentina) y sus miembros participaron en el diseño y la aplicación de políticas públicas eugénicas destinadas a evitar la despoblación y disminuir la mortalidad infantil. El presente trabajo describe dichas políticas desde la fundación de dicha institución hasta el inicio del proceso de Reforma Universitaria.
Se realizó un análisis bibliográfico de bases de datos online y catálogos de bibliotecas para identificar textos referidos a políticas de puericultura y salud pública promovidas por la FCM en el período 1877 - 1918.
Se obtuvieron un total de 11 referencias bibliográficas: tres libros, dos artículos publicados en revistas científicas y seis Tesis para optar al título de Doctor en Medicina y Cirugía de la FCM. Discusión: Se evidencia en los textos analizados un gran interés en la caracterización de la mortalidad infantil en Córdoba y la promoción de la lactancia materna exclusiva. A ello se asocia la creación y administración de instituciones de salud de puericultura entre los que se destaca el Consultorio Protector de la Infancia.
La FCM, ligada a grupos políticos cordobeses, participó activamente en la difusión de los conceptos de puericultura (cuyas destinatarias eran principalmente las mujeres-madres de estratos socioeconómicos carenciados) y en la implementación de acciones tendientes al crecimiento poblacional y la inculcación de valores morales aceptados por sus académicos.

The review analyzes the fundamental work of V. I. Borodulin about the history of Internal Disease Clinic in the USSR, based on the biographies of more than fifty prominent Soviet therapeutists; the research is devoted to development of main Soviet therapeutic scientific schools and formation of new scientific and educational clinical disciplines in this field in 1920s-1970s, as well as difficulties and dynamic life of therapeutic elite in the USSR in that period.
Представлен анализ фундаментального труда В. И. Бородулина по истории клиники внутренних болезней в СССР, в котором освещены деятельность более чем 50 выдающихся советских терапевтов, история развития основных отечественных терапевтических школ и выделение новых самостоятельных научно-учебных клинических дисциплин в период 1920-х - 1970-х годов. Отражена сложная и динамичная жизнь терапевтической элиты СССР этого периода.

Our aims were to provide updated information on placebo/nocebo effect and the potential use of placebo in clinical practice. This article can only provide a rough overview on the placebo and nocebo effect and is intended to serve as a starting point for the reader to go deeper into the corresponding literature. The placebo effect has been observed in multiple medical conditions, after oral administration, with manual therapies as well as with surgery and invasive procedures. The use of placebo in clinical trials is fundamental, although the ethics of its use is under discussion. The placebo may behave like a drug from the pharmacokinetic and pharmacodynamic point of view and can also be associated with adverse events (nocebo effect). Placebo can modify treatment by increasing or decreasing the effects of drugs. The factors associated with the occurrence of placebo effect are multiple, but in addition to those that depend on the placebo itself, the doctor-patient relationship would be the most important. As a result of findings that were published in the last two decades, the psycho-neurobiological basis of placebo is becoming better understood, although further studies are needed. In conclusion, the placebo effect in the clinic exhibits weak to moderate intensity. Placebo, in addition to its use in the clinical trial, should be considered another therapeutic remedy either as stand alone or in association with treatment, and could be useful in certain circumstances. The use of placebo should be regulated by the European health authorities through a guide in clinical practice that will improve patient care.

We are at an exciting moment in time with the advancement of many vaccines, including a shigella vaccine for the world. It is instructive to look at the long road that some vaccines have traveled to recognize the remarkable accomplishments of those who were pioneers, appreciate the evolution of scientific and applied technology, and inform the future history of a vaccine that would have great potential for global health. To achieve this valuable retrospective, a narrative historical literature review was undertaken utilizing PubMed and Embase databases with relevant search terms. Retrieved articles were reviewed and information was organized into historical themes, landmark discoveries, and important vaccine development parallels. The literature reviewed was synthesized into major eras of shigella vaccine development from pathogen discovery and first attempts to empirical approaches of killed whole-cell and live-attenuated approaches, and a modern era that applied recombinant DNA engineering and structural vaccinology. The history of shigella vaccine development has largely followed the evolutionary path of vaccine development over the last 120 years, but with important lessons learned that should be considered as we embark on the future chapters of bringing to the world a safe and effective vaccine for global health.