■一些研究报告了戊型肝炎病毒(HEV)在中国不同地区的流行情况,但是结果差异很大。在这里,我们进行了系统评价和荟萃分析,以评估血清阳性率,RNA阳性率,中国HEV基因型分布,及其风险因素。
■我们纳入了1997年至2022年间发表的208项相关研究,涉及1,785,569名参与者。随机效应模型用于汇集患病率,亚组分析按人群进行,性别,年龄,学习期间,regions,和城乡分布。使用meta回归模型和合并比值比(OR)来确定HEV感染的危险因素。
■合并的抗HEVIgG,IgM,和Ag血清阳性率,1997-2022年中国的RNA检出率为23.17%[95%置信区间(CI):20.23-26.25],0.73%(95%CI:0.55-0.93),0.12%(95%CI:0.01-0.32),和6.55%(95%CI:3.46-12.05),分别。在职业人群(48.41%;95%CI:40.02-56.85)和年龄在50-59岁的老年人(40.87%;95%CI:31.95-50.11)中,抗HEVIgG血清阳性较高。中国戊型肝炎的优势基因型(GT)为GT4。值得注意的是,饮用非自来水(OR=1.82;95%CI:1.50-2.20),食用生肉或未煮熟的肉(OR=1.47;95%CI:1.17-1.84),和少数民族(OR=1.50;95%CI:1.29-1.73)是抗HEVIgG血清阳性率的危险因素。
■总的来说,戊型肝炎在中国的患病率相对较高,尤其是老年人,少数民族,以及职业接触猪的人类。因此,有必要采取预防措施,包括HEV感染筛查和监测,健康教育,和戊型肝炎疫苗在高风险地区和人群的干预。
■https://www.crd.约克。AC.英国/普华永道/,标识符CRD42023397036。
UNASSIGNED: Several studies have reported on hepatitis E virus (HEV) prevalence in various regions of China, but the results vary widely. Herein, we conducted a systematic
review and meta-analysis to assess the seroprevalence, RNA-positive rate, genotype distribution of HEV in China, and its risk factors.
UNASSIGNED: We included 208 related studies involving 1,785,569 participants published between 1997 and 2022. Random-effects models were used to pool prevalence, and subgroup analyses were conducted by population, gender, age, study period, regions, and rural-urban distribution. The meta regression models and pooled odds ratios (OR) were performed to identify risk factors for HEV infections.
UNASSIGNED: The pooled anti-HEV IgG, IgM, and Ag seroprevalence, and RNA detection rates in China from 1997 to 2022 were 23.17% [95% confidence interval (CI): 20.23-26.25], 0.73% (95% CI: 0.55-0.93), 0.12% (95% CI: 0.01-0.32), and 6.55% (95% CI: 3.46-12.05), respectively. The anti-HEV IgG seropositivity was higher in the occupational population (48.41%; 95% CI: 40.02-56.85) and older adult aged 50-59 years (40.87%; 95% CI: 31.95-50.11). The dominant genotype (GT) of hepatitis E in China was GT4. Notably, drinking non-tap water (OR = 1.82; 95% CI: 1.50-2.20), consumption of raw or undercooked meat (OR = 1.47; 95% CI: 1.17-1.84), and ethnic minorities (OR = 1.50; 95% CI: 1.29-1.73) were risk factors of anti-HEV IgG seroprevalence.
UNASSIGNED: Overall, the prevalence of hepatitis E was relatively high in China, especially among older adults, ethnic minorities, and humans with occupational exposure to pigs. Thus, there is a need for preventive measures, including HEV infection screening and surveillance, health education, and hepatitis E vaccine intervention in high-risk areas and populations.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier CRD42023397036.