■驱虫药的持续使用导致了全球性的耐药性问题。解决此问题的一个突破是利用源自农业工业废物中活性化合物的生物驱虫药。这项体内研究调查了Podang芒果(MangiferaindicaL.)果皮废物提取物用于驱虫目的的有效性,使用浓度高达5%。
■这项研究包括28只17个月大的Etawa杂交山羊。山羊被随机分为四组:阴性对照,水果皮提取物(AFPE)组,2.5%,另一组AFPE为5%,和接受伊维菌素的阳性对照。选择的山羊在暴露于扭曲的Haemonchus之前,每克的鸡蛋(EPG)数量超过1000。在为期9周的研究中的7天,给予了波当芒果的AFPE。第七天,阳性对照组给予伊维菌素。AFPE剂量取决于每公斤动物体重的平均皱胃液。喂养方案包括浓缩和狼尾草。Mott是为牲畜的营养需求而定制的。饲料消费数据,消化率,平均每日收益,粪便卵数减少百分比,身体状况评分,在整个研究过程中收集临床参数。
■在较高的治疗水平(AFPE)下,EPG和粪便卵数均有较大减少.维持消耗和消化率的预期和正常范围。虽然体重增加,FAMACHA参数显示下降。与阴性对照组相比,血红蛋白存在实质性差异(p<0.05),红细胞,阳性对照组和治疗组的血细胞比容。血尿素氮和肌酐,指示肝脏和肾脏健康,在正常范围内。
■在浓度高达5%时,Podang芒果废物提取物(AFPE)可以替代山羊的传统蠕虫药物或生物驱虫药,提高他们的生产。
UNASSIGNED: The continuous use of anthelmintic drugs has led to global issues of resistance. One breakthrough to address this problem is the utilization of bio-anthelmintics derived from active compounds in agro-industrial waste. This in vivo study investigated the effectiveness of Podang mango (Mangifera indica L.) fruit peel waste extract for anthelmintic purposes, using concentrations up to 5%.
UNASSIGNED: This study included 28 Etawa crossbred goats aged 17 months. Goats were randomly assigned to four groups: A negative control, an aqueous fruit peel extract (AFPE) group at 2.5%, another AFPE group at 5%, and a positive control receiving ivermectin. Goats chosen had egg per gram (EPG) counts surpassing 1000 before exposure to Haemonchus contortus. For 7 days within a 9-week study, AFPE from Podang mangoes was given. On the 7th day, the positive control group was administered ivermectin. AFPE dosage relied on the average abomasum fluid per kilogram of animal weight. The feeding regimen consisted of concentrate and Pennisetum purpureum cv. Mott is customized for the nutritional needs of livestock. Data on feed consumption, digestibility, average daily gain, percentage reduction in fecal egg count, body condition score, and clinical parameters were collected throughout the study.
UNASSIGNED: At higher treatment levels (AFPE), there was a greater reduction in both EPG and fecal egg counts. The expected and normal ranges were maintained for consumption and digestibility. While body weight increased, FAMACHA parameters showed a decrease. Compared to the negative control group, substantial disparities (p < 0.05) existed for hemoglobin, red blood cells, and hematocrit in both the positive control and the treatment groups. Blood urea nitrogen and creatinine, indicative of liver and kidney health, were within normal ranges.
UNASSIGNED: At a concentration of up to 5%, Podang mango waste extract (AFPE) can function as a substitute for traditional helminth medicines or bio-anthelmintics in goats, enhancing their production.