HIV stigma

艾滋病毒耻辱
  • 文章类型: Journal Article
    背景:携带艾滋病毒/艾滋病对同性恋来说更加困难,双性恋,和酷儿(G-BQ)的人,因为他们在疾病和性行为上都面临耻辱,这给应对压力源带来了巨大的压力,在线平台已经成为另一种应对渠道。
    方法:本研究调查了在马来西亚使用在线应对策略来缓解由性身份污名介导的HIV污名对心理健康的影响。123名年龄在20至39岁之间的HIV感染者参与了这项研究,对艾滋病毒污名的回应-简短形式的量表,适应中国MSM污名量表,在线应对库存,DASS-21
    结果:使用OLS分析结果,和逻辑回归路径模型显示了性别认同污名介导HIV污名对抑郁的统计显著间接影响(ab=0.1362),焦虑(ab=0.1259),和应力(ab=0.1636)水平。发现以问题为中心的在线应对策略通过低(β=0.2110,SE=0.0741,p<.05)和中等水平(β=0.1168,SE=0.0465,p<.05)的性认同污名来减轻HIV污名和抑郁水平之间的间接关联。研究结果表明,艾滋病毒和性身份污名与心理健康之间的复合联系,以及如何将在线应对策略用作有用的应对资源,以管理社区和心理健康从业者的抑郁症状。
    结论:这些发现有助于更好地理解双重柱头在心理健康中的作用,以及为处理马来西亚HIV感染者的压力源而采用的在线应对策略类型。
    BACKGROUND: Living with HIV/AIDS is more difficult for gay, bisexual, and queer (G- BQ) people as they face stigma on both the disease and sexuality, which puts significant stress on coping with stressors, and online platforms have become an alternative coping channel.
    METHODS: This study investigated the use of online coping strategies in moderating the HIV stigma mediated by sexual identity stigma on mental health in Malaysia. 123 GBQ people living with HIV between the ages of 20 and 39 participated in the study, responding to the HIV Stigma - Short Form Scale, adapted China MSM Stigma Scale, Online Coping Inventory, and DASS-21.
    RESULTS: Results were analyzed using OLS, and logistic regression path modeling showed a statisti- cally significant indirect effect of sexual identity stigma mediating HIV stigma on depressive (ab = 0.1362), anxiety (ab = 0.1259), and stress (ab = 0.1636) levels. Problem-focused online coping strategy was found to moderate the indirect association between HIV stigma and depression levels via sexual identity stigma at low (β = 0.2110, SE = 0.0741, p<.05) and moderate levels (β = 0.1168, SE = 0.0465, p<.05). The findings demonstrated the compounding link between HIV and sexual identity stigmas on mental health and how online coping strategies can be used as a helpful coping resource to manage depressive symptoms for this community and mental health practition- ers.
    CONCLUSIONS: These findings can be beneficial to generate a better understanding of how double stigmas play a role in mental health and the types of online coping strategies adopted to process the stressors for GBQ individuals living with HIV in Malaysia.
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  • 文章类型: Journal Article
    撒哈拉以南非洲有140多万青少年感染艾滋病毒,他们中的大多数人通过围产期传播(PHIVE)获得病毒。艾滋病毒的污名在感染艾滋病毒的青少年中尤其严重,并且与一些结果有关,这些结果使健康状况恶化并增加了艾滋病毒继续传播的风险。我们在一年的时间里,在索韦托的一名男性青少年样本中,测试了内化的艾滋病毒污名和其中四个结果之间的关联,南非。参与者(N=241)在基线时回答了有关内在化HIV污名的问题。他们在接下来的一年中完成了每周的移动调查,以回答有关抑郁症经历的问题,暴饮暴食,药物依从性,暴力受害。使用广义线性混合模型,我们发现,基线内化的HIV污名与抑郁几率增加相关(OR1.74),酒精滥用(OR2.09),以及暴力受害(OR1.44)和一年内药物依从性的几率降低(OR0.60)。这些结果对感染艾滋病毒的青少年的健康和福祉产生负面影响,并增加他们将来将艾滋病毒传播给伴侣的风险。我们的发现提供了新颖的,艾滋病毒污名有害影响的纵向证据。为了改善患有艾滋病毒的青少年的健康结果,至关重要的是制定有效的减少艾滋病毒污名的干预措施,以解决特定的发展问题,性别,和文化体验。
    There are over 1.4 million adolescents living with HIV in sub-Saharan Africa, the majority of whom acquired the virus through perinatal transmission (PHIV). HIV stigma is particularly high among adolescents living with HIV and is associated with several outcomes that worsen health and increase the risk of onward HIV transmission. We tested associations between internalized HIV stigma and four of these outcomes over a one-year period among a sample of adolescent boys living with PHIV in Soweto, South Africa. Participants (N = 241) answered questions about internalized HIV stigma at baseline. They completed weekly mobile surveys over the following year to answer questions about their experiences with depression, binge drinking, medication adherence, and violence victimization. Using generalized linear mixed models, we found that baseline internalized HIV stigma was associated with increased odds of depression (OR 1.74), alcohol misuse (OR 2.09), and violence victimization (OR 1.44) and decreased odds of medication adherence (OR 0.60) over the course of a year. These outcomes negatively impact the health and wellbeing of adolescents living with PHIV and increase their risk of transmitting HIV to their partners in the future. Our findings provide novel, longitudinal evidence for the deleterious effects of HIV stigma. To improve health outcomes for adolescents with PHIV, it will be crucial to develop effective HIV stigma reduction interventions that address specific developmental, gendered, and cultural experiences.
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  • 文章类型: Journal Article
    背景:2021年,中国法院,根据新颁布的民法典,由于配偶在婚前未能披露其艾滋病毒感染情况,首先吊销了结婚证。这个具有里程碑意义的案件引发了关于艾滋病毒感染者(PLHIV)是否有法律义务告知其配偶和性伴侣的新辩论。医学的进步已经部分隔离了性接触中的艾滋病毒传播,将披露义务的法律依据扩展到疾病预防之外。本研究调查了中国PLHIV在履行这一职责方面可能面临的一些不可预见的挑战,以及他们根据政府促进健康的目标做出的决定的结果。
    方法:本研究旨在详细研究中国PLHIV中有关伴侣告知的法律规定和实践。2019年至2020年采用了混合方法研究方法,结合问卷调查,深入采访,参与式观察。通过在中国PLHIV在线平台上发布的问卷,共获得433份有效回复。在对问卷数据进行收集和随机编码之后,选择了40名艾滋病毒感染者进行深入访谈。随后,在金华市关爱家(爱心家园)进行了为期六个月的实地调查,以进一步探讨这一问题。
    结果:相当比例的PLHIV对其配偶的披露率很高(近80%)。在性伴侣的背景下,56%的PLHIV表示他们的性伴侣知道他们的HIV感染。无论是已婚PLHIV向配偶披露,还是未婚/离婚PLHIV向性伴侣披露,然而,绝大多数人对披露可能导致的对他们关系的潜在破坏表示担忧。在婚外关系中的已婚PLHIV中观察到唯一的例外,在这种情况下,他们的关注程度略有下降。未披露的原因主要包括检测不到病毒载量和采取保护措施。
    结论:这项研究表明,普遍存在的“艾滋病毒耻辱”阻碍了艾滋病毒感染者自愿履行《艾滋病毒/艾滋病预防和控制条例》第38条赋予的披露义务,新《民法典》不明确的法律规定在这方面发挥了重要作用。解决这一问题不仅需要提高社会对PLHIV的容忍度,减少社会排斥的情况,而且还需要将披露义务的法律基础从疾病预防转移到有关各方法律关系中的权利和义务。当涉及到披露的接受者时,例如,区分配偶和性伴侣至关重要。至于PLHIV未能履行披露职责,除了涉及间接通知的干预外,增加进一步的法律责任可能是不可取的。故意传播行为,另一方面,仍然应该受到严厉的惩罚。
    背景:不适用。
    BACKGROUND: In 2021, a Chinese court, based on the newly enacted Civil Code, first revoked a marriage license due to the spouse\'s failure to disclose their HIV infection before the marriage. This landmark case ignited a fresh debate on whether people living with HIV (PLHIV) have a legal duty to inform their spouses and sexual partners. Advances in medicine have partially isolated HIV transmission from sexual contact, extending the legal basis for the obligation to disclose beyond disease prevention. This study investigates some possibly unforeseen challenges for PLHIV in China to fulfill this duty, and the outcomes of their decisions in light of the government\'s goal to promote health.
    METHODS: This study aims to provide a detailed examination of the legal provisions and practices concerning partner notification among PLHIV in China. A mixed-methods research approach was employed between 2019 and 2020, combining questionnaire surveys, in-depth interviews, and participatory observations. A total of 433 valid responses were obtained through a questionnaire posted on a Chinese online platform for PLHIV. Following the collection and random coding of the questionnaire data, 40 individuals living with HIV were selected for in-depth interviews. Subsequently, a six-month field investigation was conducted in Guan ai jia yuan (Caring Home) in Jinhua City to further explore this issue.
    RESULTS: A considerable proportion of PLHIV exhibit a high rate of disclosure to their spouses (nearly 80%). In the context of sexual partners, 56% of PLHIV stated that their sexual partners were aware of their HIV infection. Whether married PLHIV disclosing to their spouses or unmarried/divorced PLHIV disclosing to sexual partners, however, a substantial majority expressed apprehension about the potential disruption to their relationships that the disclosure might cause. The sole exception was observed among married PLHIV in extramarital relationships who demonstrated a slightly diminished level of concern in this context. Reasons for non-disclosure predominantly included undetectable viral load and the adoption of protective measures.
    CONCLUSIONS: This study reveals that a prevailing \"HIV stigma\" hinders PLHIV from voluntarily fulfilling the disclosure duties bestowed by Article 38 of the Regulations on the Prevention and Control of HIV/AIDS, and the unclear legal provisions of the new Civil Code play a significant role in this regard. Addressing this issue necessitates not only increasing societal tolerance toward PLHIV and reducing instances of social exclusion but also shifting the legal basis of disclosure duties from disease prevention to rights and obligations within the legal relationships of the parties involved. When it comes to the recipients of disclosure, for instance, it is crucial to differentiate between spouses and sexual partners. As for PLHIV failing to fulfill their disclosure duties, apart from interventions involving indirect notifications, the addition of further legal responsibilities may not be advisable. Intentional transmission actions, on the other hand, should still be subject to severe penalties.
    BACKGROUND: Not applicable.
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  • 文章类型: Journal Article
    这项研究检查了两种基于小组的干预措施的可行性和可接受性:小组认知行为疗法(G-CBT)和通过多家庭组(MFG-FS)进行的家庭强化干预。以解决青少年感染艾滋病毒(ALHIV)及其照顾者中的艾滋病毒污名。对乌干达7个政治区内9个诊所的147名青少年照顾者进行了资格筛选。其中,89个二元组符合纳入标准,并同意参与研究。参与者被随机分配,在诊所层面,三种研究条件之一:日常护理,G-CBT或MFG-FS。干预措施在3个月内完成。虽然青少年及其照顾者都参加了MFG-FS会议,G-CBT课程只有青少年参加。数据在基线时收集,干预开始后3个月和6个月。在研究期间保留率为94%。跨群体,干预会议出勤率在85%到92%之间,对于所有会议。干预的保真度在85%到100%之间,儿童和看护人对干预会议的满意度都很高。乌干达的ALHIV,撒哈拉以南非洲的大部分地区,在减少污名干预措施中仍然代表性不足。Suubi4Stigma研究对青少年及其照顾者是可行和可接受的-支持在更大的试验中测试干预措施的有效性。
    This study examined the feasibility and acceptability of two group-based interventions: group-cognitive behavioral therapy (G-CBT) and a family-strengthening intervention delivered via multiple family group (MFG-FS), to address HIV stigma among adolescents living with HIV (ALHIV) and their caregivers. A total of 147 adolescent -caregiver dyads from 9 health clinics situated within 7 political districts in Uganda were screened for eligibility. Of these, 89 dyads met the inclusion criteria and provided consent to participate in the study. Participants were randomized, at the clinic level, to one of three study conditions: Usual care, G-CBT or MFG-FS. The interventions were delivered over a 3-month period. While both adolescents and their caregivers attended the MFG-FS sessions, G-CBT sessions were only attended by adolescents. Data were collected at baseline, 3 and 6-months post intervention initiation. The retention rate was 94% over the study period. Across groups, intervention session attendance ranged between 85 and 92%, for all sessions. Fidelity of the intervention was between 85 and 100%, and both children and caregivers rated highly their satisfaction with the intervention sessions. ALHIV in Uganda, and most of sub-Saharan Africa, are still underrepresented in stigma reduction interventions. The Suubi4Stigma study was feasible and acceptable to adolescents and their caregivers -supporting testing the efficacy of the interventions in a larger trial.
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  • 文章类型: Journal Article
    背景:与人类免疫缺陷病毒(HIV)相关的污名是一个重要的全球公共卫生问题。卫生保健提供者和决策者继续努力理解和实施战略,以减少在特定情况下和在额外压迫的交叉点与艾滋病毒相关的耻辱。艾滋病毒感染者的观点和方向至关重要。
    方法:在这个项目中,我们放大了艾滋病毒感染者关于他们在马尼托巴省与艾滋病毒相关的耻辱经历的声音,加拿大。我们使用基于艺术的定性案例研究设计,使用photovoice和叙事访谈。感染艾滋病毒的成年人通过拍照来代表他们的耻辱经历。这些照片是后续个人叙事采访中有关艾滋病毒和污名的对话的催化剂。日记为参与者提供了反思他们的经验的机会,和抵抗,污名。访谈是录音和转录的。照片,期刊,采用归纳定性方法对转录访谈进行分析,结果:通过图片和对话,参与者(N=11;64%的女性)表达了压迫性结构以及人际关系态度和行为所产生和支持的污名的情感和社会影响。这些经历因包括种族主义在内的相互交叉的压迫形式而变得更加复杂,性别歧视,和同性恋恐惧症。参与者还讲述了他们的个人策略和面对污名化的转变的故事。策略的主题是关心自己,照顾孩子和宠物,重建社会支持网络,抵制和破坏耻辱。与会者就制度和政策改革提出了重要建议。
    结论:这些压迫和抵抗的故事可以激发行动,以减少与艾滋病毒相关的耻辱。艾滋病毒感染者可以考虑这些故事中分享的应对耻辱的策略。卫生保健提供者和政策制定者可以采取协调一致的行动,以支持人们向抵制污名的过渡。它们可以促进支持性和反压迫性的健康和社会服务系统,以解决医疗保健以及对食物的基本需求,庇护所,收入,以及积极的社会和社区联系。
    The stigma associated with human immunodeficiency virus (HIV) is a significant global public health concern. Health care providers and policy makers continue to struggle with understanding and implementing strategies to reduce HIV-related stigma in particular contexts and at the intersections of additional oppressions. Perspectives and direction from people living with HIV are imperative.
    In this project we amplified the voices of people living with HIV about their experiences of HIV-related stigma in Manitoba, Canada. We used an arts-based qualitative case study research design using photovoice and narrative interviews. Adults living with HIV participated by taking pictures that represented their stigma experiences. The photos were a catalyst for conversations about HIV and stigma during follow-up individual narrative interviews. Journaling provided opportunities for participants to reflect on their experiences of, and resistance to, stigma. Interviews were audio recorded and transcribed. Photos, journals, and transcribed interviews were analyzed using inductive qualitative methods RESULTS: Through pictures and dialogue, participants (N = 11; 64% women) expressed the emotional and social impacts of stigmas that were created and supported by oppressive structures and interpersonal attitudes and behaviours. These experiences were compounded by intersecting forms of oppression including racism, sexism, and homophobia. Participants also relayed stories of their personal strategies and transitions toward confronting stigma. Strategies were themed as caring for oneself, caring for children and pets, reconstituting social support networks, and resisting and disrupting stigma. Participants made important recommendations for system and policy change.
    These stories of oppression and resistance can inspire action to reduce HIV-related stigma. People living with HIV can consider the strategies to confront stigma that were shared in these stories. Health care providers and policy makers can take concerted actions to support peoples\' transitions to resisting stigmas. They can facilitate supportive and anti-oppressive health and social service systems that address medical care as well as basic needs for food, shelter, income, and positive social and community connections.
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  • 文章类型: Journal Article
    背景:50岁及以上的HIV感染者(PWH)数量正在增加。老年PWH(年龄≥50岁)的护理问题日益受到关注。了解老年人的护理偏好可以更好地为他们提供护理服务。这项研究的目的是调查护理偏好(家庭护理,自我照顾,机构护理,以社区为基础的护理,和互助护理)在老年PWH中,并确定影响其护理偏好的因素。
    方法:从2021年5月至11月,对年龄较大的PWH(年龄≥50岁)进行了一项关于护理偏好的横断面调查。我们使用便利抽样登记了319名参与者。我们设计了一份问卷来评估老年PWH的护理偏好。采用卡方检验和Fisher精确检验对护理偏好进行单因素分析。多元logistic回归用于确定影响护理偏好的因素。
    结果:大多数年龄较大的PWH(72.7%)首选家庭护理,很少(15.7%)喜欢自我护理。年龄较大的PWH更倾向于社区护理(5.3%),机构护理(5.0%)和互助护理(1.3%)。多变量分析表明,有房子的老年PWH,配偶和更多子女更倾向于选择家庭护理(p<.05)。年长的PWH独自生活,有更高的月收入和更高的艾滋病毒污名倾向于选择自我护理(p<0.05)。
    结论:家庭护理是老年PWH的首选模式,自我护理排名第二。更喜欢机构护理的人数,社区护理和互助护理很少。国家和政府应采取措施合理分配老年人的护理资源,以更好地满足老年人的护理需求。要加强社会保障,减少内化的艾滋病毒耻辱,改善社会支持,探索多元化的护理模式,以提高老年PWH患者的生活质量。
    The number of people living with HIV (PWH) aged 50 and above is increasing. The question of care among older PWH (aged ≥ 50 years) is an increasing concern. Understanding the care preference of older people can better provide care services for them. The purpose of this study was to investigate the care preference (home-based care, self-care, institutional care, community-based care, and mutual-aid care) among older PWH and identify the factors affecting their care preference.
    A cross-sectional survey was conducted among older PWH (aged ≥ 50 years) about care preference from May to November 2021. We enrolled 319 participants using convenience sampling. We designed a questionnaire to assess the care preference of older PWH. The Chi-square test and Fisher\'s exact test were used to conduct univariate analysis of care preference. Multinomial logistic regression was used to identify factors influencing care preference.
    Most older PWH (72.7%) preferred home-based care, and few (15.7%) preferred self-care. Fewer older PWH preferred community-based care (5.3%), institutional care (5.0%) and mutual-aid care (1.3%). Multivariate analysis showed that older PWH with a house, spouse and more children were more inclined to choose home-based care (p < .05). Older PWH living alone, having higher monthly income and higher HIV stigma preferred to choose self-care (p < .05).
    Home-based care was the most preferred model of older PWH, and self-care ranked second. The number of those who preferred institutional care, community-based care and mutual-aid care were few. Nation and government should take measures to allocate care resources for older adults reasonably to better meet the care needs of older PWH. It is important to strengthen social security, reduce internalized HIV stigma, improve social support, and explore diversified care models for improving the quality of life of older PWH.
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  • 文章类型: Journal Article
    背景:“治疗所有人”政策建议在所有HIV感染者(PLHIV)确诊后立即进行抗逆转录病毒治疗(ART),现在在撒哈拉以南非洲普遍存在。虽然早期ART启动和保留可有效减少疾病进展和传播,有证据表明,污名可能成为参与护理的障碍。这项研究试图在“治疗所有人”的背景下了解卢旺达的艾滋病毒污名与参与PLHIV护理之间的关系。
    方法:在2018年9月至2019年3月之间,我们进行了半结构化,在基加利的两个健康中心接受治疗的成人PLHIV的定性访谈,卢旺达。我们使用扎根的理论方法进行数据分析,以开发概念框架,描述在卢旺达早期实施“全面治疗”政策的背景下,污名如何影响艾滋病毒护理的参与。
    结果:在37名参与者中,27名(73%)为女性,中位年龄为31岁。参与者描述了在对待所有人下的护理参与,包括服药和参加预约,增加了他们作为PLHIV的知名度。这有助于使艾滋病毒和抗逆转录病毒疗法的使用正常化,但也导致在治疗的早期阶段,卫生中心和社区中预期的污名化。家庭和社区成员的污名化以及由此产生的内化污名化成为护理参与的额外障碍。尽管如此,参与者描述了护理提供者和家庭成员的社会心理支持如何帮助他们应对耻辱并促进他们继续参与护理.
    结论:卢旺达的所有政策都提高了艾滋病毒在个人和社会层面的知名度,这影响了艾滋病毒的耻辱,归一化,心理社会支持和护理参与复杂的方式。利用PLHIV描述的个人和社区支持来提供基于证据的,同伴或提供者提供的减少污名的干预措施可能有助于实现所有目标。
    \'Treat All\' policies recommending immediate antiretroviral therapy (ART) soon after HIV diagnosis for all people living with HIV (PLHIV) are now ubiquitous in sub-Saharan Africa. While early ART initiation and retention is effective at curtailing disease progression and transmission, evidence suggests that stigma may act as a barrier to engagement in care. This study sought to understand the relationships between HIV stigma and engagement in care for PLHIV in Rwanda in the context of Treat All.
    Between September 2018 and March 2019, we conducted semi-structured, qualitative interviews with adult PLHIV receiving care at two health centers in Kigali, Rwanda. We used a grounded theory approach to data analysis to develop conceptual framework describing how stigma influences HIV care engagement in the context of early Treat All policy implementation in Rwanda.
    Among 37 participants, 27 (73%) were women and the median age was 31 years. Participants described how care engagement under Treat All, including taking medications and attending appointments, increased their visibility as PLHIV. This served to normalize HIV and use of ART but also led to high levels of anticipated stigma in the health center and community at early stages of treatment. Enacted stigma from family and community members and resultant internalized stigma acted as additional barriers to care engagement. Nonetheless, participants described how psychosocial support from care providers and family members helped them cope with stigma and promoted continued engagement in care.
    Treat All policy in Rwanda has heightened the visibility of HIV at the individual and social levels, which has influenced HIV stigma, normalization, psychosocial support and care engagement in complex ways. Leveraging the individual and community support described by PLHIV to deliver evidence-based, peer or provider-delivered stigma reduction interventions may aid in attaining Treat All goals.
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  • 文章类型: Journal Article
    背景:照顾艾滋病毒/艾滋病患者(PLWHA)需要临床经验和优质的护理服务技巧。本研究旨在探讨护理专业学生在照顾PLWHA方面的看法和经验。
    方法:这项定性描述性研究通过半结构化电话访谈,采访了来自中国7个省14家三级医院的18名护理PLWHA的实习护士。
    结果:叙述中出现了两个主题:学生护士对PLWHA的看法和态度以及学生护士对PLWHA的实践经验。揭示了五个主题集群,即“护理前的消极态度,\"\"护理中的一系列心理斗争,“\”在给予照顾后,有利的态度增加了,“\”关于为PLWHA提供护理的共识,“和”关于减少污染的注意事项。“
    结论:研究结果揭示了学生护士在整个临床经验中对PLWHA的看法的发展和变化。学生护士对PLWHA的看法和态度经历了三个不同的阶段,护理后观察到积极变化。参与者对艾滋病患者的看法和实践经验使患者能够接受公平和高质量的护理,并为护理教育者更好地准备HIV护士提供有价值的见解。
    BACKGROUND: Caring for people living with HIV/AIDS (PLWHA) requires clinical experience and quality care delivery skills. This study aimed to explore the perceptions and experiences of nursing students in caring for PLWHAs.
    METHODS: This qualitative descriptive study interviewed 18 student nurses who had cared for PLWHAs from 14 tertiary hospitals across 7 provinces in China through semi-structured telephone interviews.
    RESULTS: Two themes emerged from the narratives: student nurses\' perceptions and attitudes toward PLWHAs and student nurses\' practical experiences with PLWHAs. Five theme clusters were revealed, namely \"negative attitudes held before the care-giving,\" \"a series of psychological struggles in care-giving,\" \"favorable attitudes increased after the care-giving,\" \"consensus on care delivery for PLWHAs,\" and \"considerations regarding contamination reduction.\"
    CONCLUSIONS: Findings shed light on the development and changes in student nurses\' perspectives on PLWHAs throughout their clinical experiences. Student nurses\' perceptions and attitudes toward PLWHAs progressed through three distinct stages, and positive changes were observed after care-giving. Participants\' perceptions and practical experiences with patients with AIDS enable patients to receive fair and high-quality care and provide valuable insights for nursing educators better prepare HIV nurses.
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  • 文章类型: Clinical Trial
    在赞比亚和南非参与HPTN(071)PopART试验的21个社区中,调查个人和社区水平的HIV污名和HIV发病率之间的关联。
    对2013年至2018年36个月的基于人群的队列随访数据进行二次分析。结果是在进入队列时HIV阴性的个体中HIV事件感染率。个人层面的暴露,在所有参与者的随机样本中测量,有:(1)社区对耻辱的看法,(2)在健康环境中对污名的看法,以及(3)对艾滋病毒感染者的恐惧和判断。个人水平的分析进行了调整,个体水平泊松回归。社区一级的艾滋病毒污名暴露利用了艾滋病毒感染者报告的数据,卫生工作者和社区成员。我们使用线性回归来探索HIV污名和社区水平HIV发病率之间的关联。
    在8172名HIV阴性患者中,他们在招募时回答了个人层面的污名问题,没有证据表明任何领域的HIV污名与HIV感染事件风险之间存在统计学显著关联.在26,110个人的整个队列中,其中艾滋病毒发病率被测量,没有证据表明社区级别的HIV发病率与HIV污名的任何领域相关.
    艾滋病毒的污名通常被认为是艾滋病毒预防计划有效性的障碍。然而,在HPTN071\“PopART试验的设置中,“单独测量的污名与艾滋病毒感染的风险无关。
    To investigate the association between individual and community-level measures of HIV stigma and HIV incidence within the 21 communities participating in the HPTN (071) PopART trial in Zambia and South Africa.
    Secondary analysis of data from a population-based cohort followed-up over 36 months between 2013 and 2018. The outcome was rate of incident HIV infection among individuals who were HIV negative at cohort entry. Individual-level exposures, measured in a random sample of all participants, were: (1) perception of stigma in the community, (2) perception of stigma in health settings and (3) fear and judgement towards people living with HIV. Individual-level analyses were conducted with adjusted, individual-level Poisson regression. Community-level HIV stigma exposures drew on data reported by people living with HIV, health workers and community members. We used linear regression to explore the association between HIV stigma and community-level HIV incidence.
    Among 8172 individuals who were HIV negative and answered individual-level stigma questions at enrolment to the cohort, there was no evidence of a statistically significant association between any domain of HIV stigma and risk of incident HIV infection. Among the full cohort of 26,110 individuals among whom HIV incidence was measured, there was no evidence that community-level HIV incidence was associated with any domain of HIV stigma.
    HIV stigma is often cited as a barrier to the effectiveness of HIV prevention programming. However, in the setting for the HPTN 071 \"PopART trial,\" measured stigma alone was not associated with the risk of HIV infection.
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  • 文章类型: Journal Article
    UNASSIGNED:艾滋病毒感染者(PLHIV)对抗逆转录病毒治疗(ART)的依从性低仍然是一个关键问题,特别是在弱势群体中。尽管ART可以大大降低与HIV相关的死亡率和发病率,低治疗依从性继续影响ART的有效性.考虑到ART通常与之相关的良好临床结果需要高水平的依从性,理解限制高水平治疗依从性的复杂背景和个人因素仍然至关重要.在引入ART多年后,许多南非社区的依从性差仍然是一个问题。
    UNASSIGNED:我们的研究试图了解导致该患者人群不坚持的具体因素和它们之间的相互作用,以便设计成功的和上下文适当的干预措施来支持PLHIV中ART的坚持。
    UNASSIGNED:这项混合方法研究采用了针对研究的问卷(N=103)和半结构化访谈(N=8),以调查与海德菲尔德社区不遵守有关的因素开普敦日中心,南非。
    UNASSIGNED:超过一半(57.3%)的参与者是ART非粘附者。不依从性与年龄较小有关,消极的自我形象和对ART必要性的低信念(P<0.05)。在病人访谈中,酒精使用,治疗疲劳和污名化是导致依从性欠佳的原因。
    UNASSIGNED:结果表明,在南非社区仍然需要对环境敏感的干预措施来支持PLHIV。未来的研究需要确保这些有针对性的干预措施考虑到这些因素。
    UNASSIGNED: Low adherence to antiretroviral treatment (ART) in people living with HIV (PLHIV) remains a critical issue, especially in vulnerable populations. Although ART is responsible for greatly reducing the mortality and morbidity associated with HIV, low treatment adherence continues to impact the effectiveness of ART. Considering that a high level of adherence to ART is required for the excellent clinical outcomes with which ART is often associated, understanding the complex contextual and personal factors that limit high levels of treatment adherence remains paramount. Poor adherence remains an issue in many South African communities many years after the introduction of ART.
    UNASSIGNED: Our study sought to understand the specific factors and the interactions among them that contribute to non-adherence in this patient population in order to devise successful and contextually appropriate interventions to support ART adherence in PLHIV.
    UNASSIGNED: This mixed-methods study employed a study-specific questionnaire (N = 103) and semi-structured interviews (N = 8) to investigate the factors linked to non-adherence at the Heideveld Community Day Centre in Cape Town, South Africa.
    UNASSIGNED: Over half (57.3%) of participants were ART non-adherent. Non-adherence was correlated with younger age, negative self-image and a low belief in the necessity of ART (P < 0.05). In patient interviews, alcohol use, treatment fatigue and stigmatisation emerged as contributors to suboptimal adherence.
    UNASSIGNED: The results suggest that there remains a need for context-sensitive interventions to support PLHIV in South African communities. Future research needs to ensure that these targeted interventions take these factors into consideration.
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