Photodynamic therapy (PDT) is a non-invasive therapy that has made significant progress in treating different diseases, including cancer, by utilizing new nanotechnology products such as graphene and its derivatives. Graphene-based materials have large surface area and photothermal effects thereby making them suitable candidates for PDT or photo-active drug carriers. The remarkable photophysical properties of graphene derivates facilitate the efficient generation of reactive oxygen species (ROS) upon light irradiation, which destroys cancer cells. Surface functionalization of graphene and its materials can also enhance their biocompatibility and anticancer activity. The paper delves into the distinct roles played by graphene-based materials in PDT such as photosensitizers (PS) and drug carriers while at the same time considers how these materials could be used to circumvent cancer resistance. This will provide readers with an extensive discussion of various pathways contributing to PDT inefficiency. Consequently, this comprehensive review underscores the vital roles that graphene and its derivatives may play in emerging PDT strategies for cancer treatment and other medical purposes. With a better comprehension of the current state of research and the existing challenges, the integration of graphene-based materials in PDT holds great promise for developing targeted, effective, and personalized cancer treatments.

Membrane-based water treatment has emerged as a promising solution to address global water challenges. Graphene oxide (GO) has been successfully employed in membrane filtration processes owing to its reversible properties, large-scale production potential, layer-to-layer stacking, great oxygen-based functional groups, and unique physicochemical characteristics, including the creation of nano-channels. This review evaluates the separation performance of various GO-based membranes, manufactured by coating or interfacial polymerization with different support layers such as polymer, metal, and ceramic, for endocrine-disrupting compounds (EDCs) and pharmaceutically active compounds (PhACs). In most studies, the addition of GO significantly improved the removal efficiency, flux, porosity, hydrophilicity, stability, mechanical strength, and antifouling performance compared to pristine membranes. The key mechanisms involved in contaminant removal included size exclusion, electrostatic exclusion, and adsorption. These mechanisms could be ascribed to the physicochemical properties of compounds, such as molecular size and shape, hydrophilicity, and charge state. Therefore, understanding the removal mechanisms based on compound characteristics and appropriately adjusting the operational conditions are crucial keys to membrane separation. Future research directions should explore the characteristics of the combination of GO derivatives with various support layers, by tailoring diverse operating conditions and compounds for effective removal of EDCs and PhACs. This is expected to accelerate the development of surface modification strategies for enhanced contaminant removal.

This review focuses on recent advances in concrete durability using graphene oxide (GO) as a nanomaterial additive, with a goal to fill the gap between concrete technology, chemical interactions, and concrete durability, whilst providing insights for the adaptation of GO as an additive in concrete construction. An overview of concrete durability applications, key durability failure mechanisms of concrete, transportation mechanisms, chemical reactions involved in compromising durability, and the chemical alterations within a concrete system are discussed to understand how they impact the overall durability of concrete. The existing literature on the durability and chemical resistance of GO-reinforced concrete and mortar was reviewed and summarized. The impacts of nano-additives on the durability of concrete and its mechanisms are thoroughly discussed, particularly focusing on GO as the primary nanomaterial and its impact on durability. Finally, research gaps, future recommendations, and challenges related to the durability of mass-scale GO applications are presented.

This paper provides a comprehensive overview of recent advancements in membrane modification for fouling mitigation in various water treatment processes, employing carbon nanomaterials such as fullerenes, nanodiamonds, carbon quantum dots, carbon nanotubes, and graphene oxide. Currently, using different carbon nanomaterials for polymeric membrane fouling mitigation is at various stages: CNT-modified membranes have been studied for more than ten years and have already been tested in pilot-scale setups; tremendous attention has been paid to utilizing graphene oxide as a modifying agent, while the research on carbon quantum dots\' influence on the membrane antifouling properties is in the early stages. Given the intricate nature of fouling as a colloidal phenomenon, the review initially delves into the factors influencing the fouling process and explores strategies to address it. The diverse chemistry and antibacterial properties of carbon nanomaterials make them valuable for mitigating scaling, colloidal, and biofouling. This review covers surface modification of existing membranes using different carbon materials, which can be implemented as a post-treatment procedure during membrane fabrication. Creating mixed-matrix membranes by incorporating carbon nanomaterials into the polymer matrix requires the development of new synthetic procedures. Additionally, it discusses promising strategies to actively suppress fouling through external influences on modified membranes. In the concluding section, the review compares the effectiveness of carbon materials of varying dimensions and identifies key characteristics influencing the antifouling properties of membranes modified with carbon nanomaterials.

Cyclodextrin (CD), a cyclic oligosaccharide from enzymatic starch breakdown, plays a crucial role in pharmaceuticals, food, agriculture, textiles, biotechnology, chemicals, and environmental applications, including water and wastewater treatment. In this study, a statistical analysis was performed using VOSviewer and Citespace to scrutinize 2038 articles published from 1993 to 2022. The investigation unveiled a notable upsurge in pertinent articles and citation counts, with China and USA contributing the highest publication volumes. The prevailing research focus predominantly revolves around the application of CD-based materials used as adsorbents to remove conventional contaminants such as dyes and metals. The CD chemistry allows the construction of materials with various architectures, including cross-linked, grafted, hybrid or supported systems. The main adsorbents are cross-linked CD polymers, including nanosponges, fibres and hybrid composites. Additionally, research efforts are actually concentrated on the synthesis of CD-based membranes, CD@graphene oxide, and CD@TiO2. These materials are proposed as adsorbents to remove emerging pollutants. By employing bibliometric analysis, this study delivers a comprehensive retrospective review and synthesis of research concerning CD-based adsorbents for the removal of contaminants from wastewater, thereby offering valuable insights for future large-scale application of CD-based adsorption materials.

Cancer is a severe disease that, in 2022, caused more than 9.89 million deaths worldwide. One worrisome type of cancer is bone cancer, such as osteosarcoma and Ewing tumors, which occur more frequently in infants. This study shows an active interest in the use of graphene oxide and its derivatives in therapy against bone cancer. We present a systematic review analyzing the current state of the art related to the use of GO in treating osteosarcoma, through evaluating the existing literature. In this sense, studies focused on GO-based nanomaterials for potential applications against osteosarcoma were reviewed, which has revealed that there is an excellent trend toward the use of GO-based nanomaterials, based on their thermal and anti-cancer activities, for the treatment of osteosarcoma through various therapeutic approaches. However, more research is needed to develop highly efficient localized therapies. It is suggested, therefore, that photodynamic therapy, photothermal therapy, and the use of nanocarriers should be considered as non-invasive, more specific, and efficient alternatives in the treatment of osteosarcoma. These options present promising approaches to enhance the effectiveness of therapy while also seeking to reduce side effects and minimize the damage to surrounding healthy tissues. The bibliometric analysis of photothermal and photochemical treatments of graphene oxide and reduced graphene oxide from January 2004 to December 2022 extracted 948 documents with its search strategy, mainly related to research papers, review papers, and conference papers, demonstrating a high-impact field supported by the need for more selective and efficient bone cancer therapies. The central countries leading the research are the United States, Iran, Italy, Germany, China, South Korea, and Australia, with strong collaborations worldwide. At the same time, the most-cited papers were published in journals with impact factors of more than 6.0 (2021), with more than 290 citations. Additionally, the journals that published the most on the topic are high impact factor journals, according to the analysis performed, demonstrating the high impact of the research field.

Advanced oxidation processes stand as green alternatives for the decontamination of waste waters. Photocatalysis is an advanced oxidation process in which a semiconductor material absorbs photon energy and triggers redox reactions capable of degrading organic pollutants. Titanium dioxide (TiO2, titania) represents one of the most popular choices of photocatalytic materials, however the UV-activation of its anatase phase and its high charge recombination rate decrease its photocatalytic activity and weaken its potential. Graphene oxide is a 2D carbon nanomaterial consisting of exfoliated sheets of hexagonally arranged carbons decorated with oxygen- and hydrogen- functional groups. Composite nanomaterials consisting of titania nanoparticles and graphene oxide have proven to enhance the photocatalytic activity of pure TiO2. In this review, we present a thorough literature review of ternary nanocomposites based on synthesized or commercial titania nanoparticles and GO (or reduced GO) particularly used for the photodegradation of dyes. GO/TiO2 has been enriched primarily with metals, semiconductors and magnetic nanomaterials, proving a superior dye degradation performance and reusability compared to bare TiO2. Ongoing challenges and perspectives are outlined.

The use of graphecs excellent mechanical properties. However, it is necessary to evaluate the biological effects of this material. This systematic review aimed to observe and understand through studies the current state of the art regarding osseointegration, antimicrobial capacity, and the cytotoxicity of graphene coating applied to the surface of dental implant materials. Searches in PubMed, Embase, Science Direct, Web of Science, and Google Scholar databases were conducted between June and July 2021 and updated in May 2022 using the keywords: graphene, graphene oxide, dental implants, zirconium, titanium, peek, aluminum, disilicate, methyl-methacrylate, cytotoxicity, osseointegration, and bone regeneration. The criteria included in vivo and in vitro studies that evaluated antimicrobial capacity and/or osseointegration and/or cytotoxicity of dental implant materials coated with graphene compounds. The risk of bias for in vitro studies was assessed by the JBI tool, and for in vivo studies, Syrcle\'s risk of bias tool for animal studies was used. The database search resulted in 176 articles. Of the 18 articles selected for full reading, 16 remained in this systematic review. The use of graphene compounds as coatings on the surface of implant materials is promising because it promotes osseointegration and has antimicrobial capacity. However, further studies are needed to ensure its cytotoxic potential.

BACKGROUND: Hyperthermia-based therapies have shown great potential for clinical applications such as for the antitumor and antipathogenic activities. Within all strategies, the so-called photothermal therapy proposes to induce the hyperthermia by the remote laser radiation on a photothermal conversion agent, in contact with the target tissue.
METHODS: This paper reviews the most relevant in vitro and in vivo studies focused on NIR laser-induced hyperthermia due to photoexcitation of graphene oxide (GO) and reduced graphene oxide (rGO). Relevant parameters such as the amount of GO/rGO, the influence of the laser wavelength and power density are considered. Moreover, the required temperature and exposure time for each antitumor/antipathogenic case are collected and unified in a thermal dose parameter: the CEM43.
RESULTS: The calculated CEM43 thermal doses revealed a great variability for the same type of tumor/strain. In order to detect potential tendencies, the values were classified into four ranges, varying from CEM43 < 60 min to CEM43 ≥ 1 year. Thus, a preference for moderate thermal doses of CEM43 < 1 year was detected in antitumor activity, with temperatures ≤ 50 °C and exposure time ≤ 15 min. In case of the antipathogenic studies, the most used thermal dose was higher, CEM43 ≥ 1 year, with ablative hyperthermia (> 60ºC).
CONCLUSIONS: The ability of GO/rGO as effective photothermal conversion agents to promote a controlled hyperthermia is proven. The variability found for the CEM43 thermal doses on the reviewed studies reveals the potentiality to evaluate, for each application, the use of lower temperatures, by modulating time and/or repetitions in the doses.

In recent years, graphene and its derivatives, owing to their phenomenal surface, and mechanical, electrical, and chemical properties, have emerged as advantageous materials, especially in terms of their potential for antimicrobial applications. Particularly important among graphene\'s derivatives is graphene oxide (GO) due to the ease with which its surface can be modified, as well as the oxidative and membrane stress that it exerts on microbes. This review encapsulates all aspects regarding the functionalization of graphene-based materials (GBMs) into composites that are highly potent against bacterial, viral, and fungal activities. Governing factors, such as lateral size (LS), number of graphene layers, solvent and GBMs\' concentration, microbial shape and size, aggregation ability of GBMs, and especially the mechanisms of interaction between composites and microbes are discussed in detail. The current and potential applications of these antimicrobial materials, especially in dentistry, osseointegration, and food packaging, have been described. This knowledge can further drive research that aims to look for the most suitable components for antimicrobial composites. The need for antimicrobial materials has seldom been more felt than during the COVID-19 pandemic, which has also been highlighted here. Possible future research areas include the exploration of GBMs\' ability against algae.