PDF(Pubmed)
Abstract：
The use of graphecs excellent mechanical properties. However, it is necessary to evaluate the biological effects of this material. This systematic review aimed to observe and understand through studies the current state of the art regarding osseointegration, antimicrobial capacity, and the cytotoxicity of graphene coating applied to the surface of dental implant materials. Searches in PubMed, Embase, Science Direct, Web of Science, and Google Scholar databases were conducted between June and July 2021 and updated in May 2022 using the keywords: graphene, graphene oxide, dental implants, zirconium, titanium, peek, aluminum, disilicate, methyl-methacrylate, cytotoxicity, osseointegration, and bone regeneration. The criteria included in vivo and in vitro studies that evaluated antimicrobial capacity and/or osseointegration and/or cytotoxicity of dental implant materials coated with graphene compounds. The risk of bias for in vitro studies was assessed by the JBI tool, and for in vivo studies, Syrcle\'s risk of bias tool for animal studies was used. The database search resulted in 176 articles. Of the 18 articles selected for full reading, 16 remained in this systematic review. The use of graphene compounds as coatings on the surface of implant materials is promising because it promotes osseointegration and has antimicrobial capacity. However, further studies are needed to ensure its cytotoxic potential.
摘要：
使用石墨优异的机械性能。然而,有必要评估这种材料的生物学效应。这篇系统的综述旨在通过研究来观察和理解关于骨整合的最新技术，抗菌能力，以及应用于牙科种植材料表面的石墨烯涂层的细胞毒性。在PubMed中搜索,Embase,科学直接，WebofScience,和GoogleScholar数据库在2021年6月至7月之间进行，并于2022年5月使用关键字：石墨烯，氧化石墨烯,牙科植入物,锆,钛，偷看,铝，二硅酸盐,甲基丙烯酸甲酯,细胞毒性，骨整合，和骨骼再生。该标准包括体内和体外研究,其评估涂覆有石墨烯化合物的牙科植入物材料的抗微生物能力和/或骨整合和/或细胞毒性。通过JBI工具评估了体外研究的偏倚风险，对于体内研究，使用Syrcle的偏倚风险工具进行动物研究。数据库搜索产生了176篇文章。在选择进行全面阅读的18篇文章中，16在本系统审查中仍然存在。使用石墨烯化合物作为植入物材料表面的涂层是有希望的,因为它促进骨整合并且具有抗微生物能力。然而,需要进一步研究以确保其细胞毒性潜力.
