背景:中央性巨细胞肉芽肿(CGCG)是一种良性,增殖性,骨内,非牙源性病变主要发生在儿童和年轻人中。在组织学层面上,它的特征是许多多核巨细胞随机散布在梭形间质基质细胞的海洋中,这些细胞分散在包含出血区域的纤维血管结缔组织基质中。说到射线照相特征,CGCG可以有一系列的变化,从明确定义的扩张性病变到不明确的破坏性病变,有或没有扩张。
方法:本病例报告回顾了一名11岁的白种人患者,主要主诉为累及右下颌后区的缓慢增长的肿胀。锥形束计算机断层扫描(CBCT)显示出一个模糊的混合病变,模仿了纤维骨病变和血管瘤。然而,显微镜检查显示纤维基质中有多核巨细胞,提示中央性巨细胞肉芽肿。
结论:我们报告此病例的目的是强调彻底临床的重要性,影像学和组织病理学检查,以进行准确的诊断和治疗干预,并强调在检查头颈部骨肿胀时考虑不同可能性的重要性。
BACKGROUND: A central giant cell granuloma (CGCG) is a benign, proliferative, intraosseous, and non-odontogenic lesion occurring primarily in children and young adults. On the histological level, it is characterized by numerous multinucleated giant cells scattered randomly throughout a sea of spindle-shaped mesenchymal stromal cells which are dispersed throughout the fibrovascular connective tissue stroma containing areas of haemorrhage. When it comes to radiographic features, CGCG can have an array of variations, ranging from well-defined expansile lesions to ill-defined and destructive lesions, with or without expansion.
METHODS: This
case report reviews an 11-year-old Caucasian patient with a chief complaint of slow-growing swelling involving the right posterior mandibular region. The cone beam computed tomography (CBCT) revealed an ill-defined mixed lesion mimicking both fibro-osseous lesion and hemangioma. However, microscopic examination revealed multinucleated giant cells in a fibrous stroma suggestive of central giant cell granuloma.
CONCLUSIONS: Our intent in reporting this
case is to highlight the importance of thorough clinical, radiographical and histopathological examination for accurate diagnosis and therapeutic interventions as well as to emphasize the importance of taking different possibilities into consideration when examining bony swellings in the head and neck region.