PDF(Pubmed)
Abstract：
Giant cell granuloma is a local nonneoplastic lesion that is divided into two categories, based on its site of occurrence: Central and peripheral giant cell granuloma. Central giant cell granuloma is an intraosseous lesion that has a tendency to recure even in surgically treated cases. Several studies have proven that there is an association between different lesions clinical behavior and their histological features. The aim of this study was to evaluate the expression of AgNOR and Ki67 in lesions with and without recurrency.
Files and records of 35 patients who had been histologically diagnosed with central giant cell granuloma were investigated. Histological features were studied after performing AgNOR staining and Ki67 marker. The data were analyzed by chi-square, Fisher, and T-test.
Acquired data indicated that the count of AgNOR staining and Ki67 marker was significantly higher in lesions with recurrency than the lesions with no recurrency. The same results were attained from Ki67 intensity.
The current study indicated that AgNOR staining and Ki67 marker have prognostic value in predicting recurrency of central giant cell granuloma lesions.
Files and records of 35 patients who had been histologically diagnosed with central giant cell granuloma were investigated. Histological features were studied after performing AgNOR staining and Ki67 marker. The data were analyzed by chi-square, Fisher, and T-test.
Acquired data indicated that the count of AgNOR staining and Ki67 marker was significantly higher in lesions with recurrency than the lesions with no recurrency. The same results were attained from Ki67 intensity.
The current study indicated that AgNOR staining and Ki67 marker have prognostic value in predicting recurrency of central giant cell granuloma lesions.
摘要：
目的：巨细胞肉芽肿是一种局部非肿瘤性病变，分为两类，根据其发生部位：中枢和外周巨细胞肉芽肿。中央巨细胞肉芽肿是一种骨内病变，即使在手术治疗的病例中也有复发的趋势。多项研究证明，不同病变的临床行为与其组织学特征之间存在关联。这项研究的目的是评估有无复发的病变中AgNOR和Ki67的表达。
方法：对35例经组织学诊断为中心性巨细胞肉芽肿的患者的档案和记录进行调查。在进行AgNOR染色和Ki67标记后研究组织学特征。数据采用卡方分析，费希尔,和T检验。
结果：获得的数据表明，有复发的病变的AgNOR染色和Ki67标记计数明显高于无复发的病变。从Ki67强度获得相同的结果。
结论：目前的研究表明，AgNOR染色和Ki67标记物对预测中央性巨细胞肉芽肿病变复发具有预后价值。
方法：对35例经组织学诊断为中心性巨细胞肉芽肿的患者的档案和记录进行调查。在进行AgNOR染色和Ki67标记后研究组织学特征。数据采用卡方分析，费希尔,和T检验。
结果：获得的数据表明，有复发的病变的AgNOR染色和Ki67标记计数明显高于无复发的病变。从Ki67强度获得相同的结果。
结论：目前的研究表明，AgNOR染色和Ki67标记物对预测中央性巨细胞肉芽肿病变复发具有预后价值。
