未经证实:局灶性节段性肾小球硬化(FSGS)在肾移植后有很高的复发率,这显著影响肾移植物的存活。然而,与复发相关的因素仍不清楚.
UNASSIGNED:本研究旨在分析肾移植后肾小球硬化的局灶性节段复发和演变。
未经批准:这是描述性的,回顾性研究纳入了在15年内接受肾移植的88名成人.人口统计学和临床特征,以及移植物丢失的发生,进行了分析。在学习期间,88例移植后诊断为FSGS的患者被鉴定。
未经证实:患者(n=54,男性)的平均年龄为29.1岁。以已故供体移植为主(60.9%)。在96.4%的初始免疫抑制方案中存在钙调磷酸酶和泼尼松抑制剂。大于0.5g/g的蛋白尿的平均发作时间为20.51天。移植后60个月,44.16%的患者部分缓解,25.97%完全缓解,和29.87%没有缓解。然而,50.60%的患者在整个分析期间出现移植物丢失。8名患者(9.4%)在60个月内死亡,其中5例(62.5%)归因于感染。
未经证实:我们的结果表明,肾移植后FSGS是一种高复发的疾病,通常是早熟,光学显微镜下的组织学改变与蛋白尿的出现不同时。高血压被认为是导致进展和复发的危险因素。因此,需要前瞻性研究来更好地评估进展和复发因素.
UNASSIGNED: Focal segmental glomerulosclerosis (FSGS) has a high recurrence rate after renal transplantation, which significantly impacts renal graft survival. However, the factors related to recurrence remain unclear.
UNASSIGNED: This
study aimed to analyze focal segmental recurrence and evolution of glomerulosclerosis after renal transplantation.
UNASSIGNED: This was a descriptive, retrospective
study involving 88 adults who underwent renal transplantation within a 15-year period. Demographic and clinical characteristics, as well as the occurrence of graft loss, were analyzed. Over the
study period, 88 patients with a diagnosis of FSGS after transplantation were identified.
UNASSIGNED: The mean age of the patients (n=54, males) was 29.1 years. Transplants with deceased donors predominated (60.9%). Calcineurin and prednisone inhibitors were present in 96.4% of the initial immunosuppression regimens. The mean time of onset of proteinuria greater than 0.5 g/g was 20.51 days. At 60 months after transplantation, 44.16% of the patients had partial remission, 25.97% had complete remission, and 29.87% had no remission. However, 50.60% of the patients developed graft loss throughout the analyzed period. Eight patients (9.4%) died within 60 months, of which five (62.5%) were attributed to infection.
UNASSIGNED: Our results indicate that FSGS after renal transplantation is a disease of high recurrence that is commonly precocious, and the histological alterations in light microscopy are not simultaneous to the appearance of proteinuria. Hypertension is considered a risk factor causing progression and recurrence. Thus, prospective studies are required to better evaluate progression and recurrence factors.