Abstract：
BACKGROUND: Direct peritoneal resuscitation (DPR) is associated with improved outcomes in trauma. Animal models suggest DPR has favorable effects on the liver. We sought to evaluate its safety and assess for improved outcomes in liver transplantation (LT).
METHODS: LT patients with renal dysfunction and/or obesity were enrolled in a phase-I clinical trial. DPR lasted 8-24 h depending on postoperative disposition. Primary outcome was percent of patients completing DPR. Secondary outcomes evaluated complications. Controls with either obesity (control-1) or both risk factors (obesity + renal dysfunction, control-2) were analyzed.
RESULTS: Fifteen patients were enrolled (seven with both criteria and eight with obesity alone). DPR was completed in 87 % of patients, with one meeting stopping criteria. Controls included 45 (control-1) and 24 (control-2) patients. Return to operating room, graft loss, and late infections were lower with DPR.
CONCLUSIONS: DPR appears to be safe in closed abdomens following LT, warranting a follow-up phase-II trial to assess efficacy.
METHODS: LT patients with renal dysfunction and/or obesity were enrolled in a phase-I clinical trial. DPR lasted 8-24 h depending on postoperative disposition. Primary outcome was percent of patients completing DPR. Secondary outcomes evaluated complications. Controls with either obesity (control-1) or both risk factors (obesity + renal dysfunction, control-2) were analyzed.
RESULTS: Fifteen patients were enrolled (seven with both criteria and eight with obesity alone). DPR was completed in 87 % of patients, with one meeting stopping criteria. Controls included 45 (control-1) and 24 (control-2) patients. Return to operating room, graft loss, and late infections were lower with DPR.
CONCLUSIONS: DPR appears to be safe in closed abdomens following LT, warranting a follow-up phase-II trial to assess efficacy.
摘要：
背景：直接腹膜复苏（DPR）与创伤预后改善相关。动物模型表明DPR对肝脏具有良好的作用。我们试图评估其安全性并评估肝移植（LT）的改善结果。
方法：患有肾功能不全和/或肥胖的LT患者被纳入I期临床试验。DPR持续8-24小时，具体取决于术后处置。主要结果是完成DPR的患者百分比。次要结果评估并发症。具有肥胖（对照1）或同时具有危险因素（肥胖+肾功能不全，对照-2)进行分析。
结果：纳入了15例患者（7例符合两项标准，8例仅有肥胖）。87%的患者完成了DPR，一个会议停止标准。对照包括45名(对照-1)和24名(对照-2)患者。回到手术室,移植物丢失，DPR的晚期感染较低。
结论：DPR在LT术后腹部闭合时似乎是安全的，保证随访II期试验以评估疗效。
方法：患有肾功能不全和/或肥胖的LT患者被纳入I期临床试验。DPR持续8-24小时，具体取决于术后处置。主要结果是完成DPR的患者百分比。次要结果评估并发症。具有肥胖（对照1）或同时具有危险因素（肥胖+肾功能不全，对照-2)进行分析。
结果：纳入了15例患者（7例符合两项标准，8例仅有肥胖）。87%的患者完成了DPR，一个会议停止标准。对照包括45名(对照-1)和24名(对照-2)患者。回到手术室,移植物丢失，DPR的晚期感染较低。
结论：DPR在LT术后腹部闭合时似乎是安全的，保证随访II期试验以评估疗效。
