未经证实:移植后糖尿病(PTDM)是一种已知的副作用,比如他克莫司。本研究旨在探讨PTDM的相关危险因素,建立PTDM的风险预测模型。此外,我们探讨了PTDM对肾移植受者移植物存活率的影响。
未经证实:肾移植前糖尿病前期患者被排除,495名肾移植受者被纳入我们的研究,他们被分配到非PTDM和PTDM组。计算3个月时的累积发生率,6个月,1年,2年,移植后3年。进行了实验室测试,他克莫司浓度,临床预后,并对不良反应进行分析。此外,采用二元logistic回归分析确定PTDM的独立危险因素.
未经评估:年龄≥45岁(调整后的优势比[aOR]2.25,95%置信区间[CI]1.14-3.92;P=0.015),体重指数(BMI)>25kg/m2(aOR3.12,95%CI2.29-5.43,P<0.001),移植后的前3个月他克莫司浓度>10ng/mL(aOR2.46,95CI1.41-7.38;P<0.001),短暂性高血糖(aOR4.53,95%CI1.86-8.03;P<0.001),延迟移植物功能(DGF)(aOR1.31,95%CI1.05-2.39;P=0.019)和急性排斥反应(aOR2.16,95%CI1.79-4.69;P=0.005)被确定为PTDM的独立危险因素。将上述六个危险因素纳入其中,建立了PTDM风险预测模型,受试者工作特征曲线下面积为0.916(95%CI0.862~0.954,P<0.001)。此外,非PTDM组的累积移植物存活率明显高于PTDM组。
未经评估:与PTDM相关的危险因素为年龄≥45岁,在移植后的前3个月内,BMI>25kg/m2,他克莫司浓度>10ng/mL,短暂性高血糖,DGF与急性排斥反应。
UNASSIGNED: Post-transplant diabetes mellitus (PTDM) is a known side effect in transplant recipients administered immunosuppressant drugs, such as tacrolimus. This study aimed to investigate the risk factors related to PTDM, and establish a risk prediction model for PTDM. In addition, we explored the effect of PTDM on the graft survival rate of kidney transplantation recipients.
UNASSIGNED: Patients with pre-diabetes mellitus before kidney transplant were excluded, and 495 kidney transplant recipients were included in our study, who were assigned to the non-PTDM and PTDM groups. The cumulative incidence was calculated at 3 months, 6 months, 1 year, 2 years, and 3 years post-transplantation. Laboratory tests were performed and the tacrolimus concentration, clinical prognosis, and adverse reactions were analyzed. Furthermore, binary logistic regression analysis was used to identify the independent risk factors of PTDM.
UNASSIGNED: Age ≥ 45 years (adjusted odds ratio [aOR] 2.25, 95% confidence interval [CI] 1.14-3.92; P = 0.015), body mass index (BMI) > 25 kg/m2 (aOR 3.12, 95% CI 2.29-5.43, P < 0.001), tacrolimus concentration > 10 ng/mL during the first 3 months post-transplantation (aOR 2.46, 95%CI 1.41-7.38; P < 0.001), transient hyperglycemia (aOR 4.53, 95% CI 1.86-8.03; P < 0.001), delayed graft function (DGF) (aOR 1.31, 95% CI 1.05-2.39; P = 0.019) and acute rejection (aOR 2.16, 95% CI 1.79-4.69; P = 0.005) were identified as independent risk factors of PTDM. The PTDM risk prediction model was developed by including the above six risk factors, and the area under the receiver operating characteristic curve was 0.916 (95% CI 0.862-0.954, P < 0.001). Furthermore, the cumulative graft survival rate was significantly higher in the non- PTDM group than in the PTDM group.
UNASSIGNED: Risk factors related to PTDM were age ≥ 45 years, BMI > 25 kg/m2, tacrolimus concentration > 10 ng/mL during the first 3 months post-transplantation, transient hyperglycemia, DGF and acute rejection.