Graft

移植物
  • 文章类型: Journal Article
    BACKGROUND: Vascular graft infection in the aortoiliac territory (abdominal VGI) is undoubtedly one of the most serious complications in vascular surgery. The treatment is burdened with high mortality and morbidity rates. In 2020, the Guidelines on the Management of Vascular Graft and Endograft Infections were published by the European Society for Vascular Surgery (ESVS). In the light of these guidelines, we decided to review retrospectively all patients who presented to our institution with abdominal VGI.
    METHODS: Retrospective observational study of patients presented with abdominal VGI treated in our institution between 20112019 (9 years). The primary goal was to elucidate the rate of vascular graft infection in aortoiliac reconstructions performed between 20112019 and also the mortality rate in the patient cohort operated for this complication. The secondary goals were to evaluate the success rate and the complication rate in different types of reconstructions.
    RESULTS: In the defined period between 20112019 we performed 363 open aortoiliac reconstructions. During the same period we treated altogether 15 patients with abdominal VGI, whose primary reconstruction was mostly performed before 2011 (11 patients). In our cohort of patients who underwent reconstruction between 20112019 we observed a graft infection only in 4 cases (1.1%). In the group of 15 patients with abdominal VGI, the male gender prevailed (14 patients). The mean age at the time of primary reconstruction was 61 years. Most of our reconstructions were performed for occlusive disease (14 cases). All infected grafts were aortobifemoral (1 unilateral aortofemoral). They were all late infections with an average presentation time of 61 months since the primary reconstruction (15180 months). Early mortality rate was as high as 27% (4 patients) and overall mortality was 40%. The secondary reinfection rate after primary treatment was 33%.
    CONCLUSIONS: Treatment of abdominal VGI is still burdened with high mortality and morbidity rates. The current ESVS guidelines provide valuable guidance for the diagnosis and management of VGI. It nevertheless remains obvious that the treatment needs to be tailored individually in a multidisciplinary team environment.
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  • 文章类型: Journal Article
    背景:Peyronie病是泌尿外科咨询的常见原因。围绕其治疗的许多争议。迄今为止,尚未发布任何法国准则。因此,法国泌尿外科协会男科和性医学委员会提供了一系列基于证据的建议。
    方法:这些建议是根据ADAPTE方法提出的,基于欧洲(EAU,ESSM),美国人(AUA,ISSM)和加拿大(CAU)建议,由于治疗的可用性,整合了法国的特异性,以及最近参考书目的更新。
    结果:对该疾病的评估是临床的。患有功能障碍或显著心理影响的患者可以接受治疗。应向患者解释每种治疗的益处和缺点。关于非手术治疗,在法国,没有可用的治疗方法获得市场授权。不推荐使用维生素E。可以根据需要提供镇痛(口服或低强度冲击波)或勃起治疗,以及牵引疗法。由于无法注射胶原酶,可以提供维拉帕米注射。在疾病的稳定阶段应考虑手术治疗,包括执行折叠,根据患者的意愿进行切口移植或阴茎植入物的放置,曲率和阴茎大小,以及勃起功能。可以提供组合治疗。
    结论:佩罗尼病的治疗是复杂的,治疗的证据水平普遍较低。治疗的成功与否将取决于初步评估的质量,患者的信息和对预期效果的理解,和从业者的经验。
    BACKGROUND: Peyronie\'s disease is a common cause for consultation in urology. Many controversies surround its treatment. No French Guidelines have been published so far. The Committee of Andrology and Sexual Medicine of the French Association of Urology therefore offers a series of evidence-based recommendations.
    METHODS: These recommendations are made according to the ADAPTE method, based on European (EAU, ESSM), American (AUA, ISSM) and Canadian (CAU) recommendations, integrating French specificities due to the availability of treatments, and an update of the recent bibliography.
    RESULTS: The assessment of the disease is clinical. Patients with functional impairment or significant psychological repercussions may be offered treatment. The benefits and drawbacks of each treatment should be explained to the patient. Regarding non-surgical treatments, no available treatment has market authorization in France. Vitamin E is not recommended. Analgesic (oral or low-intensity shock waves) or proerectile treatments may be offered as needed, as well as traction therapy. Due to the unavailability of collagenase injections, verapamil injections may be offered. Surgical treatments are to be considered in the stabilized phase of the disease, and consist of performing a plication, an incision-graft or the placement of a penile implant according to the patient\'s wishes, the curvature and the penis size, as well as erectile function. Combination treatments can be offered.
    CONCLUSIONS: The management of Peyronie\'s disease is complex, and the levels of evidence for treatments are generally low. The success of treatment will depend on the quality of the initial assessment, the patient\'s information and understanding of the expected effects, and the practitioner\'s experience.
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  • 文章类型: Journal Article
    The Spanish Multidisciplinary Group on Vascular Access (GEMAV), which includes experts from the five scientific societies involved (nephrology (S.E.N.), vascular surgery (SEACV), interventional radiology (SERAM-SERVEI), infectious diseases (SEIMC), and nephrology nursing (SEDEN)), along with the methodological support of the Iberoamerican Cochrane Centre, has developed the Spanish Clinical Guidelines on Vascular Access for Hemodialysis. This article summarizes the main issues from the guideline\'s chapter entitled \"Monitoring and surveillance of arteriovenous access.\" We will analyze the current evidence on conflicting topics such as the value of the flow-based screening methods for the arteriovenous access surveillance or the role of Doppler ultrasound as the imaging exploration to confirm suspected stenosis. In addition, the concept of significant stenosis and the criteria to perform the elective intervention for stenosis were reviewed. The adoption of these guidelines will hopefully translate into a reduced risk of thrombosis and increased patency rates for both arteriovenous fistulas and grafts.
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