研究表明,绿茶提取物(GTE)补充剂对一系列条件有益,包括几种形式的癌症,心血管,和肝脏疾病;尽管如此,现有的证据表明它对身体成分的影响,氧化应激,与肥胖相关的激素尚无定论。这项系统评价和荟萃分析旨在研究补充GTE对身体成分的影响(体重[BM],身体脂肪百分比[BFP],脂肪质量[FM],体重指数[BMI],腰围[WC]),肥胖相关激素(瘦素,脂联素,和生长素释放肽)和氧化应激(丙二醛[MDA],和总抗氧化能力[TAC])标记。我们搜索了适当的数据库,包括PubMed/Medline,Scopus,和WebofScience,截至2022年7月,以认可已发表的随机对照试验(RCT),该试验研究了GTE补充剂对上述标记物的影响。使用随机效应模型进行荟萃分析。使用I2指数评估研究之间的异质性。在从电子数据库搜索中确定的最初11286项研究中,涉及3802名参与者的59项研究有资格被纳入这项荟萃分析。集合效应大小表明BM,BFP,BMI,GTE补充后MDA显著降低。此外,GTE补充增加脂联素和TAC,对调频没有影响,瘦素,还有ghrelin.不同结果的证据确定性从低到高不等。我们的结果表明,补充GTE可以减弱氧化应激,BM,BMI,和BFP,被认为会对人类健康产生负面影响。此外,GTE作为营养膳食补充剂可以增加TAC和脂联素。
Research indicates that green tea extract (GTE) supplementation is beneficial for a range of conditions, including several forms of cancer, CVD and liver diseases; nevertheless, the existing evidence addressing its effects on body composition, oxidative stress and obesity-related hormones is inconclusive. This systematic
review and meta-analysis aimed to investigate the effects of GTE supplementation on body composition (body mass (BM), body fat percentage (BFP), fat mass (FM), BMI, waist circumference (WC)), obesity-related hormones (leptin, adiponectin and
ghrelin) and oxidative stress (malondialdehyde (MDA) and total antioxidant capacity (TAC)) markers. We searched proper databases, including PubMed/Medline, Scopus and Web of Science, up to July 2022 to recognise published randomised controlled trials (RCT) that investigated the effects of GTE supplementation on the markers mentioned above. A random effects model was used to carry out a meta-analysis. The heterogeneity among the studies was assessed using the I2 index. Among the initial 11 286 studies identified from an electronic database search, fifty-nine studies involving 3802 participants were eligible to be included in this meta-analysis. Pooled effect sizes indicated that BM, BFP, BMI and MDA significantly reduced following GTE supplementation. In addition, GTE supplementation increased adiponectin and TAC, with no effects on FM, leptin and
ghrelin. Certainty of evidence across outcomes ranged from low to high. Our results suggest that GTE supplementation can attenuate oxidative stress, BM, BMI and BFP, which are thought to negatively affect human health. Moreover, GTE as a nutraceutical dietary supplement can increase TAC and adiponectin.