Abstract：
Breast cancer (BC) is the most frequently diagnosed cancer and a leading cause of cancer-related mortality among women globally. Resistin, omentin and ghrelin, adipokines involved in inflammation and metabolic regulation, have been implicated in cancer development, yet their associations with BC remain unclear. This systematic review and meta-analysis aimed to elucidate the relationships between resistin, omentin, and ghrelin concentrations and BC, while exploring potential moderators such as body mass index (BMI) and menopausal status. A comprehensive search of electronic databases up to 13 May 2024 identified studies comparing resistin and omentin, but not ghrelin, concentrations in BC patients and healthy controls. Standardized mean differences (SMDs) were calculated using random-effects models, and meta-regression and subgroup analyses were performed to investigate sources of heterogeneity. Analysis of 11 studies showed that BC patients exhibited significantly higher resistin concentrations compared to controls, with a pooled SMD of 2.05 (95 % CI 1.24 to 2.86, p < 0.001). Meta-regression indicated that BMI significantly moderated the resistin-BC association (p = 0.003). In contrast, omentin concentrations presented a complex picture, with a pooled SMD of -0.27 (95 % CI -1.39 to 0.84, I^2 = 96.2 %, p < 0.001), indicating substantial heterogeneity and inconclusive results, whereas only one study investigated ghrelin. Our findings support a significant association between elevated resistin concentrations and BC, suggesting a potential role of resistin in BC pathophysiology. The data on omentin and ghrelin remain inconclusive, warranting further investigation. Future research should focus on large, longitudinal studies with standardized methodologies to validate these findings and clarify the role of adipokines in BC.
摘要：
乳腺癌（BC）是最常见的癌症，也是全球女性癌症相关死亡率的主要原因。Resistin,omentin和ghrelin,参与炎症和代谢调节的脂肪因子，与癌症的发展有关，然而，他们与BC的关联仍不清楚。本系统综述和荟萃分析旨在阐明抵抗素与抵抗素之间的关系。门汀,ghrelin浓度和BC，同时探索潜在的调节因素，如体重指数（BMI）和绝经状态。截至2024年5月13日，对电子数据库进行了全面搜索，确定了比较抵抗素和门汀的研究，但不是ghrelin,BC患者和健康对照中的浓度。使用随机效应模型计算标准化平均差(SMD)，进行meta回归和亚组分析以调查异质性来源.对11项研究的分析表明，与对照组相比，BC患者的抵抗素浓度显着升高，合并SMD为2.05（95%CI1.24至2.86，p<0.001）。Meta回归显示BMI显著降低抵抗素-BC相关性(p=0.003)。相比之下,网膜素浓度呈现了一幅复杂的图景，合并SMD为-0.27(95%CI-1.39至0.84，I^2=96.2%，p<0.001)，表明实质性的异质性和不确定的结果，而只有一项研究调查了ghrelin。我们的发现支持抵抗素浓度升高与BC之间的显着关联，提示抵抗素在BC病理生理学中的潜在作用。关于omentin和ghrelin的数据仍然没有定论，保证进一步调查。未来的研究应该集中在大，使用标准化方法进行纵向研究，以验证这些发现并阐明脂肪因子在BC中的作用。
