来自2020年globocan统计数据的数据表明,乳腺癌已成为癌症发病率最高的癌症。雌激素受体(ER),孕酮受体(PR)和人表皮生长因子受体2(HER2)是介导细胞生长和存活信号的已知免疫组织化学(IHC)标记。此外,调节蛋白,受体,它们的下游信号通路已经成为乳腺癌形成和增殖的关键组成部分,并已成为公认的治疗靶点和乳腺癌治疗研究的核心焦点。藤黄是Clusiaceae家族中的一个大属,其分离果实的化学成分含有广泛的生物活性代谢产物,茎皮,种子,叶子,和根,结果包括聚异戊二烯化二苯甲酮,多酚,生物类黄酮,黄原酮,内酯,和三萜。本文旨在分析藤黄属植物化学物质作为乳腺癌分子治疗的潜力。结果表明,藤黄属植物化学物质(即,α-芒果苷,坎博金,藤黄酸[GA],Garcinol,Griffipavixanthone,Friedolanostane三萜类,己烷,Neobractatin,7-Epiclusianone,xanochymol-guttiferoneE,和异氧杂木酚-环氧杂木酚)具有抗癌特性,包括细胞凋亡,抑制增殖,和转移。这篇综述对于提供有关藤黄植物化学物质作为乳腺癌患者替代疗法的信息非常重要。本文选择了28篇基于纳入标准的研究,关键词为“藤黄”和“乳腺癌”,在英语中,并在PubMed上提供全文和摘要搜索。
Data from globocan statistic in 2020 indicate that breast cancer has become highest incidence rate of cancer. Estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) are known immunohistochemistry (IHC) markers that mediate cell growth and survival signaling. Furthermore, regulator proteins, receptors, and their downstream signaling pathways have emerged as critical components in breast cancer formation and proliferation, and have become well-established therapeutic targets and the core focus of breast cancer therapy research.
Garcinia is a big genus in the Clusiaceae family that contains a wide spectrum of biologically active metabolites for the chemical composition of their isolated fruits, stem barks, seeds, leaves, and roots, have resulted including polyisoprenylated benzophenones, polyphenols, bioflavonoids, xanthones, lactones, and triterpenes. This
review article aimed to analyze the potential of
Garcinia phytochemicals as a molecular therapy of breast cancer. The results showed that phytochemicals of
Garcinia (i.e., α-mangostin, Cambogin, Gambogic Acid [GA], Garcinol, Griffipavixanthone, Friedolanostane triterpenoid, Hexane, Neobractatin, 7-Epiclusianone, xanthochymol - guttiferone E, and isoxanthochymol - cycloxanthochymol) have anticancer properties, including apoptosis, inhibition of proliferation, and metastasis. This
review is important to provide information regarding phytochemicals of
Garcinia as an alternative treatment for breast cancer patients. This article selected 28 article researches based on inclusion criteria with the keyword \"
Garcinia\" and \"Breast cancer\", in English, and available in full text and abstract searching on PubMed.