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Abstract：
Gambogic acid (GA), a kind of dry resin secreted by the Garcinia hanburyi tree, is a natural active ingredient with various biological activities, such as anti-cancer, anti-inflammatory, antioxidant, anti-bacterial effects, etc. An increasing amount of evidence indicates that GA has obvious anti-cancer effects via various molecular mechanisms, including the induction of apoptosis, autophagy, cell cycle arrest and the inhibition of invasion, metastasis, angiogenesis. In order to improve the efficacy in cancer treatment, nanometer drug delivery systems have been employed to load GA and form micelles, nanoparticles, nanofibers, and so on. In this review, we aim to offer a summary of chemical structure and properties, anti-cancer activities, drug delivery systems and combination therapy of GA, which might provide a reference to promote the development and clinical application of GA.
摘要：
藤黄酸(GA),藤黄树分泌的一种干树脂，是一种具有多种生物活性的天然活性成分，比如抗癌，抗炎,抗氧化剂，抗菌作用,等。越来越多的证据表明，GA通过各种分子机制具有明显的抗癌作用，包括细胞凋亡的诱导，自噬,细胞周期停滞和入侵的抑制，转移,血管生成。为了提高癌症治疗的疗效，纳米药物递送系统已被用于负载GA并形成胶束，纳米粒子，纳米纤维，等等。在这次审查中,我们的目标是提供化学结构和性质的总结，抗癌活动，药物递送系统和GA的联合治疗，为促进GA的发展和临床应用提供参考。
