Frailty syndrome

虚弱综合征
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    文章类型: Journal Article
    The purpose of this review is to demonstrate the importance of using a comprehensive geriatric examination in cardiology, including geriatric aspects of the management of this patient population. Until now, the Russian Federation has completely lacked a geriatric approach to the management of cardiological patients, which provides for consideration of international experience in this survey. The curation of elderly and elderly patients is complicated by the presence of geriatric syndromes and age-associated diseases leading to deterioration of quality of life, repeated hospitalizations, disability and risk of death. The leading geriatric syndrome in geriatric practice is senile asthenia and multiple comorbid polymorbid pathologies of the geriatric patient. A patient admitted to an acute care hospital with a history of cardiovascular comorbid pathology is primarily viewed as a patient at high risk for cardiovascular complications, omitting the risk of adverse outcomes, including loss of independence and impaired functional status. The following literature review demonstrates the importance of defining senile asthenia outside of the geriatrician\'s office, justifying the need for advanced training for cardiologists in geriatrics.
    Цель представленного обзора — демонстрация важности комплексного гериатрического обследования в кардиологии, включая гериатрические аспекты ведения данного контингента больных. До настоявшего времени в РФ полностью отсутствует гериатрический подход к ведению пациентов кардиологического профиля, что предусматривает рассмотрение международного опыта по данному вопросу. Курация пациентов пожилого и старческого возраста осложняется наличием гериатрических синдромов и возраст-ассоциированных заболеваний, ведущих к ухудшению качества жизни, повторным госпитализациям, инвалидизации и риску смерти. Ведущим гериатрическим синдромом для врача-гериатра является старческая астения и множественная сопутствующая полиморбидная патология. Пациента, попадающего в стационар по неотложному состоянию, имеющего в анамнезе сердечно-сосудистую коморбидную патологию, в первую очередь рассматривают как пациента с высоким риском сердечно-сосудистых осложнений, опуская значение риска неблагоприятных исходов, включающее потерю независимости и нарушение функционального статуса. Данный обзор показывает важность определения старческой астении вне кабинета гериатра, обосновывая необходимость повышения квалификации врачей-кардиологов по гериатрии.
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  • 文章类型: Journal Article
    目的是系统地回顾老年人抑郁和虚弱之间的关系。
    数据库,例如PubMed,WebofScience,Embase,从数据库创建到2023年9月1日,搜索了Scopus关于抑郁风险与虚弱之间联系的文章。一对研究人员合作进行了筛查,收集的数据,并评估了纳入研究中的偏差可能性。利用R软件进行元合成。
    纳入了8项队列研究,包括13043名参与者和14854名抑郁症患者。荟萃分析显示,老年人的虚弱与抑郁症的发生率之间存在显着联系(风险比[RR]=3.26,95%置信区间[CI]:1.68-6.32)。亚组评估显示,社区居住的老年人(RR=2.28,95%CI:0.644-8.102)和通过流行病学研究中心抑郁量表(CES-D)评估的老年抑郁症患者(RR=5.82,95%CI:0.481-70.526)之间没有联系。
    虚弱与老年人患抑郁症的风险相关。虚弱是导致老年人抑郁的一个因素。
    UNASSIGNED: The aim was to systematically review the association between depression and frailty in the elderly.
    UNASSIGNED: Databases such as PubMed, Web of Science, Embase, and Scopus were searched for articles on the link between the risk of depression and frailty since the creation of the databases to September 1, 2023. A pair of investigators collaboratively conducted the screening, collected data, and evaluated the potential for bias in the included studies. R software was utilized for meta-synthesis.
    UNASSIGNED: Eight cohort studies comprising 13 043 participants and 14 854 senior individuals with depression were included. The meta-analysis showed that there was a significant connection regarding frailty and the incidence of depression among the elderly (Risk Ratio [RR] = 3.26, 95% Confidence Interval [CI]: 1.68-6.32). Subgroup evaluations showed that there was no association between frailty and depression in the community-dwelling elderly (RR = 2.28, 95% CI: 0.644-8.102) and in the elderly patients with depression assessed by Center for Epidemiological Studies Depression Scale (CES-D) (RR = 5.82, 95% CI: 0.481-70.526).
    UNASSIGNED: Frailty is correlated with the risk of depression in the elderly. Frailty is a contributing factor to depression in the elderly.
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  • 文章类型: Case Reports
    非创伤性骨折(ATF)是一种脆性骨折亚型,偶尔会出现法医学问题。ATF被定义为裂缝,因为低能量机制通常被认为不能产生裂缝。“他们是一种被低估的疾病,流行病学变化。以前报道的ATF现象不仅发生在老年人中,而且在儿童中,年轻人,老年人,和动物。这项研究是一个简短的回顾性病例系列,探讨了三级护理大学医院的无创伤骨折。在两年的时间里,共发现7例ATF病例。然而,只有5人符合纳入标准。病理性骨折的局部原因(例如,转移)和老年人虐待或忽视被排除。病例临床概况的比较,断裂剖面,管理完成了。所有5例病例均为体弱的女性,因药物和多种疾病而产生严重的骨毒性负担。ATF的介绍包括典型(如疼痛)和非典型(如无痛,响亮的裂缝,和突然的赠品)症状学。一名ATF同时出现了原因不明的无菌热。3例骨折不止1例(骨折级联),确认并进行X光检查。除1例进行髋关节置换术外,所有病例均采用保守治疗。护理计划包括管理骨毒性多发病负担,专注于整个身体,不仅仅是骨折或骨头。该研究提供了有关ATF表现挑战的见解(如骨折急性期反应:成骨无菌热)。风险因素通常被认为是骨质疏松症,但它通常是系统性和多因素的。骨折警告标志的高风险可以帮助减少ATF的发生或骨折级联。检测到四个ATF类别,以帮助医疗保健系统识别高风险患者并提高医务人员的意识,家庭,和照顾者。未来需要对高危人群进行研究,以了解ATF知识差距,挑战,最好的治疗方法。
    Atraumatic fractures (ATFs) are a fragility fracture subtype with occasional medicolegal issues. ATFs are defined as fractures because of a \"low-energy mechanism that is usually considered incapable of producing a fracture.\" They are an underreported disorder, with epidemiological variations. ATF phenomena were previously reported not only in older adults, but also in children, young adults, older adults, and animals. This study is a short retrospective case series exploring atraumatic fractures in a tertiary care university hospital. Over a period of two years, a total of seven ATF cases were identified. However, only five fulfilled the inclusion criteria. Local causes of pathologic fractures (e.g., metastasis) and elder abuse or neglect were excluded. Comparison of the cases\' clinical profile, fracture profile, and management was done. All five cases were frail females with significant osteotoxic burdens from medications and multi-morbidities. ATF presentations included typical (as pain) and atypical (as painless, loud crack, and sudden giveaway) symptomatology. One ATF had a coincident unexplained aseptic fever. Three cases had more than one fracture (fracture cascade), confirmed and followed up by x-rays. All the cases were managed conservatively except for one case that underwent hip hemiarthroplasty. Plans of care included managing the osteotoxic multi-morbidities burden, focusing on the whole body, not only on the fracture or bone. The study provided insights about challenges in presentations of ATF (as the bone fracture acute phase reaction: osteogenic aseptic fever). Risk factors are classically assumed to be osteoporosis, but it is usually systemic and multifactorial. A high risk of fracture warning sign could help decrease ATF occurrence or fracture cascades. Four ATF categories were detected to help healthcare systems identify high-risk patients and raise awareness among medical staff, families, and caregivers. Future studies of the at-risk groups are needed to understand ATF knowledge gaps, challenges, and the best treatments.
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  • 文章类型: Journal Article
    目的:探讨停用降压药物对衰弱综合征患者特征的影响。
    方法:这项前瞻性试点研究于2016年3月至2019年7月进行。在这段时间内到衰弱诊所就诊的患者中,纳入首次就诊时接受抗高血压药物治疗并随访约1年的门诊患者.在1年随访期间停用或继续使用抗高血压药物的参与者被分为停药组或继续组,分别。Kihon清单(KCL)中的每个域,跌倒风险评分,短物理性能电池(SPPB)得分,和骨骼肌指数(SMI)在第一次访问和1年的随访评估,并对两组进行比较。
    结果:在498名到虚弱诊所就诊的患者中,78人入选(停药组,n=19;延续组,n=59)。在第一次访问时,停药组的SMI评分明显高于继续组。在为期一年的评估中,停药组KCL的体力和两组的各种SPPB评分均有显着改善,延续组的跌倒风险评分有所改善.
    结论:停用抗高血压药物可能对身体机能产生积极影响。
    OBJECTIVE: To investigate the effects of discontinuing antihypertensive drugs on the characteristics of patients with frailty syndrome.
    METHODS: This prospective pilot study was conducted between March 2016 and July 2019. Among patients who visited the frailty clinic within this period, outpatients who received antihypertensive drugs at their first visit and were followed-up for about 1 year were enrolled. Participants who discontinued or continued antihypertensive drugs during 1 year of follow-up were classified into a discontinuation group or continuation group, respectively. Each domain in the Kihon checklist (KCL), fall risk score, short physical performance battery (SPPB) score, and skeletal muscle index (SMI) were assessed at the first visit and 1-year follow-up assessment, and were compared between the two groups.
    RESULTS: Among 498 patients who attended the frailty clinic, 78 were enrolled (discontinuation group, n = 19; continuation group, n = 59). At the first visit, SMI scores were significantly higher in the discontinuation versus continuation group. At the 1-year assessment, physical strength in the KCL for the discontinuation group and various SPPB scores for both groups were significantly improved, and the fall risk score was improved in the continuation group.
    CONCLUSIONS: Discontinuation of antihypertensive drugs may positively affect physical performance.
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  • 文章类型: Journal Article
    Ubiquity (devices becoming part of the context) and transparency (devices not interfering with daily activities) are very significant in healthcare monitoring applications for elders. The present study undertakes a scoping review to map the literature on sensor-based unobtrusive monitoring of older adults\' frailty. We aim to determine what types of devices comply with unobtrusiveness requirements, which frailty markers have been unobtrusively assessed, which unsupervised devices have been tested, the relationships between sensor outcomes and frailty markers, and which devices can assess multiple markers. SCOPUS, PUBMED, and Web of Science were used to identify papers published 2010-2020. We selected 67 documents involving non-hospitalized older adults (65+ y.o.) and assessing frailty level or some specific frailty-marker with some sensor. Among the nine types of body worn sensors, only inertial measurement units (IMUs) on the waist and wrist-worn sensors comply with ubiquity. The former can transparently assess all variables but weight loss. Wrist-worn devices have not been tested in unsupervised conditions. Unsupervised presence detectors can predict frailty, slowness, performance, and physical activity. Waist IMUs and presence detectors are the most promising candidates for unobtrusive and unsupervised monitoring of frailty. Further research is necessary to give specific predictions of frailty level with unsupervised waist IMUs.
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  • 文章类型: Journal Article
    系统回顾低收入和中等收入国家(LMICs)社区居住老年人的脆弱和脆弱患病率的研究,并估计LMICs社区居住老年人的脆弱和脆弱患病率。
    系统评价和荟萃分析。PROSPERO注册号是CRD42016036083。
    MEDLINE,EMBASE,AMED,WebofScience,从成立至2017年9月12日,对CINAHL和世卫组织全球卫生图书馆进行了检索。
    低收入和中等收入国家。
    ≥60岁的社区居住老年人。
    我们筛选了7057篇引文,纳入了56篇研究。47和42项研究被纳入脆弱和脆弱荟萃分析,分别。大多数研究来自中高收入国家。低收入国家提供了一项研究。脆弱的患病率从3.9%(中国)到51.4%(古巴),脆弱的患病率从13.4%(坦桑尼亚)到71.6%(巴西)。合并的虚弱患病率为17.4%(95%CI为14.4%至20.7%,I2=99.2%),优先等级为49.3%(95%CI46.4%至52.2%,I2=97.5%)。研究中患病率的巨大差异在很大程度上可以解释为脆弱评估方法和地理区域的差异。这些发现适用于最低招募年龄为60岁、65岁和70岁的研究。
    与高收入国家相比,上中等收入国家的社区居住老年人的身体虚弱患病率更高,这对医疗保健规划具有重要意义。在中低收入国家和低收入国家中,脆弱患病率的证据有限。
    CRD42016036083。
    To systematically review the research conducted on prevalence of frailty and prefrailty among community-dwelling older adults in low-income and middle-income countries (LMICs) and to estimate the pooled prevalence of frailty and prefrailty in community-dwelling older adults in LMICs.
    Systematic review and meta-analysis. PROSPERO registration number is CRD42016036083.
    MEDLINE, EMBASE, AMED, Web of Science, CINAHL and WHO Global Health Library were searched from their inception to 12 September 2017.
    Low-income and middle-income countries.
    Community-dwelling older adults aged ≥60 years.
    We screened 7057 citations and 56 studies were included. Forty-seven and 42 studies were included in the frailty and prefrailty meta-analysis, respectively. The majority of studies were from upper middle-income countries. One study was available from low-income countries. The prevalence of frailty varied from 3.9% (China) to 51.4% (Cuba) and prevalence of prefrailty ranged from 13.4% (Tanzania) to 71.6% (Brazil). The pooled prevalence of frailty was 17.4% (95% CI 14.4% to 20.7%, I2=99.2%) and prefrailty was 49.3% (95% CI 46.4% to 52.2%, I2=97.5%). The wide variation in prevalence rates across studies was largely explained by differences in frailty assessment method and the geographic region. These findings are for the studies with a minimum recruitment age 60, 65 and 70 years.
    The prevalence of frailty and prefrailty appears higher in community-dwelling older adults in upper middle-income countries compared with high-income countries, which has important implications for healthcare planning. There is limited evidence on frailty prevalence in lower middle-income and low-income countries.
    CRD42016036083.
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