背景:毛囊炎是一种毛囊的疼痛性感染和炎症,主要由细菌引起,真菌或,很少,病毒感染。松节油衍生物传统上用于治疗各种皮肤感染,因此也可有效治疗毛囊炎。我们进行了一个开放的,prospective,随机化,安慰剂和比较对照的多中心试验,以评估含有松脂油的软膏的有效性和安全性,落叶松松节油,和桉树油治疗急性毛囊炎。
方法:70例急性毛囊炎门诊患者采用松节油软膏治疗,比较器(聚维酮碘溶液),或安慰剂(凡士林)7天。医生在四次探访时拍摄了受影响皮肤区域的照片,每天都有病人。照片由失明的观察者评估。主要功效终点是总毛囊病变计数的变化。次要终点包括研究过程中病变计数的演变,应答率(卵泡病变改善至少一个计数),和患者的全球评估。安全性终点是治疗的耐受性和不良事件记录。
结果:两种活性治疗均检测到卵泡病变计数减少,但不是安慰剂,但组间差异无统计学意义。至于次要终点,在研究过程中,软膏在病变的演变方面比安慰剂具有统计学上的显着优势(p=0.017),响应者率(p=0.032),和患者的主观疗效评估(p=0.029)。所有的治疗都同样耐受,与类似数量的治疗引起的不良事件。
结论:松节油软膏是治疗毛囊炎的有效和安全的选择。
BACKGROUND: Folliculitis is a painful infection and inflammation of the hair follicles, mostly caused by bacterial, fungal, or, more rarely, viral infections. Turpentine derivatives have been used traditionally to treat various skin infections and could thus also be effective in treating folliculitis. We carried out an open, prospective, randomized, placebo- and comparator-controlled multicenter
trial to evaluate the efficacy and safety of an ointment containing pine turpentine oil, larch turpentine, and eucalyptus oil in the treatment of acute folliculitis.
METHODS: Seventy outpatients with acute
folliculitis were treated with the turpentine ointment, a comparator (povidone iodine solution), or a placebo (Vaseline) for 7 days. Photographs of the affected skin areas were taken by the physicians at four visits and by the patients on a daily basis. Photographs were evaluated by blinded observers. Primary efficacy endpoint was the change in total hair follicle lesion counts. Secondary endpoints included the evolution of the lesion counts in the course of the
study, responder rate (improvement of follicle lesions by at least one count), and the patient\'s global assessment. Safety endpoints were the tolerability of the treatments and adverse event recording.
RESULTS: A decrease of follicle lesions counts was detected for both active treatments but not for placebo, but the differences among groups were not statistically significant. As for the secondary endpoints, the ointment showed statistically significant superiority over placebo for the evolution of the lesions during the course of the
study (p = 0.017), the responder rate (p = 0.032), and the subjective efficacy assessment by patients (p = 0.029). All treatments were equally well tolerated, with a similar number of treatment-emergent adverse events.
CONCLUSIONS: The turpentine ointment is an effective and safe option for the treatment of folliculitis.