常见的皮肤病,如寻常痤疮,酒渣鼻和毛囊炎是令人烦恼的常见的毛囊炎性疾病,可以使用光学相干断层扫描(OCT)和具有微米分辨率的反射共聚焦显微镜(RCM)轻松进行床边调查,为高分辨率毛囊诊断和定量治疗评估开辟了一个新时代。EMBASE,搜索PubMed和WebofScience,直到2023年1月5日,以确定RCM和OCT对毛囊特征进行成像的所有研究,以诊断和监测基于毛囊的皮肤病的治疗。本研究遵循PRISMA指南。在列入条款之后,使用QUADAS-2关键评估清单评估方法学质量.纳入了39项体内研究(33项RCM研究和12项OCT研究)。研究集中在寻常痤疮上,酒渣鼻,斑秃,化脓性汗腺炎,毛囊炎,毛囊炎Decalvans,扁平苔藓,盘状红斑狼疮,额叶纤维性脱发和毛发角化病。毛囊间和毛囊周围形态,包括蠕形螨的数量,角质化过度,在所有包括的皮肤疾病中,可以通过RCM和OCT评估炎症和血管形态。方法学研究质量低,研究间结果变异性很高。在36项研究中,质量评估显示偏倚风险高或不明确。RCM和OCT都将定量特征可视化为尺寸,形状,毛囊的含量和异常,并有可能支持临床诊断和评估治疗效果。然而,为了将RCM和OCT直接应用于临床实践,需要更大规模的方法学质量更好的研究.
Common skin disorders such as acne vulgaris, rosacea and
folliculitis are bothersome prevalent inflammatory diseases of hair follicles that can easily be investigated bedside using optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) with micrometre resolution, opening a novel era for high-resolution hair follicle diagnostics and quantitative treatment evaluation. EMBASE, PubMed and Web of Science were searched until 5 January 2023 to identify all studies imaging hair follicle characteristics by RCM and OCT for diagnosis and monitoring of treatment in hair follicle-based skin disorders. This study followed PRISMA guidelines. After inclusion of articles, methodological quality was assessed using the QUADAS-2 critical appraisal checklist. Thirty-nine in vivo studies (33 RCM and 12 OCT studies) were included. The studies focused on acne vulgaris, rosacea, alopecia areata, hidradenitis suppurativa,
folliculitis,
folliculitis decalvans, lichen planopilaris, discoid lupus erythemasus, frontal fibrosing alopecia and keratosis pilaris. Inter- and perifollicular morphology including number of demodex mites, hyperkeratinization, inflammation and vascular morphology could be assessed by RCM and OCT in all included skin disorders. Methodological study quality was low, and interstudy outcome variability was high. Quality assessment showed high or unclear risk of bias in 36 studies. Both RCM and OCT visualize quantitative features as size, shape, content and abnormalities of hair follicles, and have potential to support clinical diagnosis and evaluate treatment effects. However, larger studies with better methodological quality are needed to implement RCM and OCT directly into clinical practice.