Abstract：
BACKGROUND: Perforating dermatoses are heterogeneous skin disorders characterized by transepidermal elimination of dermal tissue components. Acquired perforating dermatoses can be divided into four types, according to the eliminated dermal materials: Kyrle disease, perforating reactive collagenosis, elastosis perforans serpiginosa, and perforating folliculitis. They characterize adult patients with coexisting systemic diseases, regardless of the dermal materials eliminated. The association between Kyrle disease and renal failure or diabetes mellitus is common.
METHODS: We reported the case of Kyrle disease in a patient with chronic kidney disease. A literature review was performed with the aim to highlight the associated comorbidities and point out the role of early and specific treatment of the cutaneous symptoms and manifestations.
CONCLUSIONS: Being Kyrle disease a pruritic condition which adversely affects the patient\'s quality of life, it would be desirable to place greater therapeutic attention on the alleviation of itching and on the correct management of the underlying comorbidity.
METHODS: We reported the case of Kyrle disease in a patient with chronic kidney disease. A literature review was performed with the aim to highlight the associated comorbidities and point out the role of early and specific treatment of the cutaneous symptoms and manifestations.
CONCLUSIONS: Being Kyrle disease a pruritic condition which adversely affects the patient\'s quality of life, it would be desirable to place greater therapeutic attention on the alleviation of itching and on the correct management of the underlying comorbidity.
摘要：
背景：穿孔性皮肤病是一种异质性皮肤病，其特征在于经皮清除真皮组织成分。获得性穿孔皮肤病可分为四种类型，根据消除的真皮材料：凯尔病，穿孔反应性胶原病，穿行弹性纤维变性，和毛囊炎穿孔.他们描述了患有系统性疾病的成年患者，无论真皮材料消除。Kyrle病与肾衰竭或糖尿病之间的关联很常见。
方法：我们报告了1例慢性肾病患者的Kyrle病。进行了文献综述，目的是强调相关的合并症，并指出皮肤症状和表现的早期和特异性治疗的作用。
结论：作为Kyrle病的瘙痒状况，对患者的生活质量产生不利影响，希望将更多的治疗注意力放在减轻瘙痒和正确管理潜在的合并症上。
方法：我们报告了1例慢性肾病患者的Kyrle病。进行了文献综述，目的是强调相关的合并症，并指出皮肤症状和表现的早期和特异性治疗的作用。
结论：作为Kyrle病的瘙痒状况，对患者的生活质量产生不利影响，希望将更多的治疗注意力放在减轻瘙痒和正确管理潜在的合并症上。
